the relationship between branched-chain amino acid metabolism and glucagon secretion in diabetes mellitus.

2022 Fiscal Year Final Research Report

• Project/Area Number: 21K21213
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund
• Review Section: 0909:Sports sciences, physical education, health sciences, and related fields
• Research Institution: Nagoya University
• Principal Investigator: Wada Eri 名古屋大学, 環境医学研究所, 特任助教 (90910307)
• Project Period (FY): 2021-08-30 – 2023-03-31
• Keywords: 2型糖尿病 / グルカゴン / 分岐鎖アミノ酸 / 代謝

Outline of Final Research Achievements

Dysregulation of glucagon is associated with the pathophysiology of type 2 diabetes. We previously reported that postprandial hyperglucagonemia is more obvious than fasting hyperglucagonemia in type 2 diabetes patients. Among them, postprandial hypersecretion of glucagon in the diabetic state is attributable to disordered BCAA catabolism in pancreatic islet cells. Therefore, we generated mice deficient in pancreatic α-cell-specific BCAA metabolism-related enzymes (Glucagon Cre, BDK floxed mice were crossed: αBDK-KO mice) and evaluated their glucagon secretory ability.

Free Research Field

内分泌代謝学

Academic Significance and Societal Importance of the Research Achievements

糖尿病病態では、インスリンの分泌障害に着目されがちな中、グルカゴンの分泌障害も病態に強く影響を及ぼしている。本研究ではグルカゴンの分泌障害機序を代謝の観点から解明し、食事療法および薬物療法双方への応用が期待できる。