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2022 Fiscal Year Final Research Report

Elucidation of the mechanism of dementia by frailty via skeletal muscle-derived exosomes

Research Project

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Project/Area Number 21K21219
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeMulti-year Fund
Review Section 0909:Sports sciences, physical education, health sciences, and related fields
Research InstitutionYamaguchi University

Principal Investigator

Tominaga Naoomi  山口大学, 大学院医学系研究科, 助教(テニュアトラック) (90891507)

Project Period (FY) 2021-08-30 – 2023-03-31
Keywords細胞外小胞 / エクソソーム / 骨格筋 / 老化
Outline of Final Research Achievements

Frailty has been suggested to increase the risk of developing dementia, the mechanism remains unclear. In this study, we focused on intra-organ communication coordinated by exosomes and aim to elucidate the mechanism of dementia caused by frailty. In this study, we isolated myoblasts from young and aged mouse skeletal muscle. I established primary cultures of myoblasts. I also established a collecting method of exosomes from myofiber that differentiated from myoblast. The exosomes were investigated. It was found that young and aged mouse derived-exosome have differences in protein concentration per particle, as well as differences in glycosylation. This study suggests that aging-induced alterations in the properties of exosomes are involved in aging-related diseases.

Free Research Field

分子細胞生物学

Academic Significance and Societal Importance of the Research Achievements

本研究では、老化によって分泌されるエクソソームの性質が大きく変化していることが明らかとなった。細胞間コミュニケーションに重要な役割を果たすエクソソームの性質が臓器間連関に大きく影響していると考えられる。本研究から、老化に伴うエクソソームの性質変化が老化関連疾患の解明や老化の新たな診断法の開発に大きく貢献する。

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Published: 2024-01-30  

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