Effect of Mild Hyperbaric Oxygen Exposure on Skeletal Muscle Metabolic Dysfunction in Cancer Cachexia

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K21254
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund
• Review Section: 0909:Sports sciences, physical education, health sciences, and related fields
• Research Institution: Kobe University
• Principal Investigator: Hirabayashi Takumi 神戸大学, 医学部附属病院, 理学療法士 (20911150)
• Project Period (FY): 2021-08-30 – 2024-03-31
• Keywords: がん悪液質 / 骨格筋 / 軽度高気圧酸素

Outline of Final Research Achievements

Focusing on the metabolic disturbances in skeletal muscle caused by cancer cachexia, this study suggests that a mild hyperbaric oxygen environment may increase oxygen delivery to skeletal muscle and improve its metabolism. However, increased oxidative stress and capillary regression within skeletal muscle have been observed in animal models of cancer cachexia. These findings highlight both the potential therapeutic benefits and risks of a mild hyperbaric oxygen environment, and further evaluation of safety and efficacy is warranted.

Free Research Field

リハビリテーション科学

Academic Significance and Societal Importance of the Research Achievements

本研究は、がん悪液質に伴う骨格筋の代謝障害への新たな治療アプローチとして軽度高気圧酸素環境の可能性を探るものである。この研究成果は、軽度高気圧酸素環境が骨格筋代謝を改善し、患者のQOLを向上させる可能性を示唆している。また、がん悪液質状態に関しては、骨格筋の酸化ストレスの増加という新たな問題点を浮かび上がらせ、これに対する解決策の開発に向けた基盤を築いた。