The potential of exercise-biased gut microbiota for the regulation of inflammation

2022 Fiscal Year Final Research Report

• Project/Area Number: 21K21270
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund
• Review Section: 0909:Sports sciences, physical education, health sciences, and related fields
• Research Institution: Kawasaki University of Medical Welfare
• Principal Investigator: Kawashima Masato 川崎医療福祉大学, 医療技術学部, 助教 (90909590)
• Project Period (FY): 2021-08-30 – 2023-03-31
• Keywords: 運動 / 腸内細菌叢 / メタボリックシンドローム / 炎症 / 免疫 / マクロファージ / 便移植

Outline of Final Research Achievements

The aim of this study was to examine whether the fecal microbiota transplantation from exercised mice improves obesity and its related inflammation in obese recipient mice. Despite some changes in gut microbial communities and its metabolites by the transplant of exercise-biased gut microbiota, obesity and inflammation status were not improved. These results suggest that the transplantation of exercise-biased microbes alone is insufficient to ameliorate the parameters related to obesity in recipients.

Free Research Field

運動免疫学

Academic Significance and Societal Importance of the Research Achievements

糞便移植法は、現在国内外で注目を集めている腸内細菌療法の一つである。本研究で得られた習慣的な運動の効果を有する腸内細菌叢の移植のみでは肥満レシピエントの身体的特徴や炎症状態に変化がもたらされないという知見は、これから糞便移植法を用いた治療や健康サプリメントの開発を進める上で意義あるものと考える。