Social Determinants of Dementia, Healthy Aging and Well-being: Examining positive Health Assets and Resilience factors

2022 Fiscal Year Research-status Report

• Project/Area Number: 21KK0168
• Research Institution: Osaka University
• Principal Investigator: 白井 こころ 大阪大学, 大学院医学系研究科, 特任准教授(常勤) (80530211)
• Co-Investigator(Kenkyū-buntansha): 磯 博康 国立研究開発法人国立国際医療研究センター, その他部局等, グローバルヘルス政策研究センター長 (50223053) ; 大平 哲也 福島県立医科大学, 医学部, 教授 (50448031) ; 斎藤 民 国立研究開発法人国立長寿医療研究センター, 研究所 老年学・社会科学研究センター, 部長 (80323608) ; 辻 大士 筑波大学, 体育系, 助教 (90741976) ; 劉 克洋 大阪大学, 大学院医学系研究科, 特任助教(常勤) (70900447) ; 坂庭 嶺人 大阪大学, 大学院医学系研究科, 特任助教(常勤) (20915649)
• Project Period (FY): 2021-10-07 – 2027-03-31
• Keywords: 健康長寿 / Well-being / 健康の社会的決定要因 / 認知機能 / 認知症予防

Outline of Annual Research Achievements

本研究の目的は、認知症予防を含む、高齢期の健康長寿の達成と、幸福な老いに関連する要因を検討し、健康寿命延伸と認知症予防など、幸福な老いに資する、社会心理的健康資源について明らかにすることである。そのために、改変可能な認知症発症関連要因（modifiable risk factors）と、主観的幸福感等を含むWell-beingの決定要因について、大規模コホートデータを活用した検討を行っている。今年度は、SONIC研究、JAGES研究、JPHC研究、JACC研究、ELSA研究、CHARLS研究のデータを用いて、認知症ならびに高齢期における生活習慣病の発症・有病に関連する要因の検討を行った。また、認知症の発症予防や認知機能の維持・増進に関連する、メカニズムの一端の検証を目指しており、そのための認知機能に関するデータ収集を日本国内において行った。
今年度の活動として、認知機能の測定・評価について福島県と大阪府の対象地域において、調査を行い、認知機能測定の方法と尺度の妥当性検討を実施した。また、大規模コホート研究を用いた検討として、高齢期の認知症発症・要介護認定発生・生活習慣病発症に関連する社会的決定要因の検討を進めた。結果として、1）社会階層、教育歴等の社会経済的背景、2）地域における社会参加、組織参加、趣味活動、余暇活動への参加など、社会関係の強度や頻度、3）食品摂取や労働時の身体活動、運動習慣等の生活習慣、4）笑いの頻度、笑う相手や笑いの場面、生きがい感の有無と楽観性志向などの心理的要因が、認知症の発症、要介護認定の発生と関連することを報告した。

Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

今年度の進捗として、国内におけるデータ収集と、国内外の高齢者コホートデータを用いて、認知症の発症、要介護認定等、幸福な老いの実現に関連する健康状態と、社会・心理・身体的な要因との関連性の検討を進めた。国際的な感染症拡大の影響を受けて、日本から海外への実渡航にはまだ制限があり、データのアクセス等について課題はあったが、データ分析手法や情報共有の方法について、工夫することで、予定通りの研究結果を得ることが出来た。加えて、日本国内におけるデータ収集を進めることで、今後の国際共同研究の基盤づくりを進めることが出来た。概ね順調に研究計画を進展することができたため、次年度以降の研究を更に発展させる予定である。

Strategy for Future Research Activity

本研究では、認知症発症、要介護認定、フレイル発生、高齢期の生活習慣病の発症等について、日本における特徴的な要因と、海外における普遍的な要因について、検討し今後の幸福な老いの実現に資するエビデンスの構築を行う予定である。
本研究の成果として、Livingstonらが、Lancet Comissionの認知症委員会にて報告している、9要因（2017,Livingston et al）、12要因(2020,Livingston et al)の改変可能な要因に加えて、社会的・心理的要因が認知症の発症や健康長寿の指標に関連することを明らかにした。また、高齢期の心身の健康指標の一つとして、うつ傾向や幸福度などpsychological well-beingをアウトカムにした検討も行い、関連要因の報告をした。次年度には、本研究の認知症予防に関連する成果をLancet Comission認知症委員会に情報提供し、報告を行う予定である。Well-being指標についても、国際的な比較検討を行うためのデータ収集を行い、次年度以降の分析に備えている状況である。今後更に日本国内におけるエビデンスの構築と併せて、国際共同研究を進める予定である。

Causes of Carryover

海外への渡航計画に制限が生じる期間が発生したため、渡航計画の見直しを行い、年度内の活動としては、研究遂行のために実渡航に代わる活動を実施した。一方で、実渡航を伴う海外でのデータ利用ならびに国内でのデータ収集の計画を修正したため、次年度使用額が生じた。

Research Products

• [Int'l Joint Research] University college London/King’s college London/University of Sussex(英国)
  • Country Name: UNITED KINGDOM
  • Counterpart Institution: University college London/King’s college London/University of Sussex
• [Int'l Joint Research] Harvard University(米国)
  • Country Name: U.S.A.
  • Counterpart Institution: Harvard University
• [Int'l Joint Research] 北京大学/清華大学(中国)
  • Country Name: CHINA
  • Counterpart Institution: 北京大学/清華大学
• [Int'l Joint Research] 延世大学(韓国)
  • Country Name: KOREA (REP. OF KOREA)
  • Counterpart Institution: 延世大学
• [Int'l Joint Research] Finish institute of Occupational Health/University of Turuk(フィンランド)
  • Country Name: FINLAND
  • Counterpart Institution: Finish institute of Occupational Health/University of Turuk
• [Journal Article] Smoking Cessation and Mortality from Aortic Dissection and Aneurysm: Findings from the Japan Collaborative Cohort (JACC) Study (2023)
  • Author(s): Yang Yiyi、Yamagishi Kazumasa、Kihara Tomomi、Cui Renzhe、Eshak Ehab S.、Muraki Isao、Shirai Kokoro、Tamakoshi Akiko、Iso Hiroyasu
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 30 Pages: 348～363
  • DOI: 10.5551/jat.63258
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Secondhand Smoke Exposure in Childhood and Mortality from Coronary Heart Disease in Adulthood: the Japan Collaborative Cohort Study for Evaluation of Cancer Risk (2023)
  • Author(s): Teramoto Masayuki、Iso Hiroyasu、Muraki Isao、Shirai Kokoro、Tamakoshi Akiko
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 30 Pages: 863～870
  • DOI: 10.5551/jat.63857
  • Peer Reviewed
• [Journal Article] Social isolation, loneliness, and their correlates in older Japanese adults (2023)
  • Author(s): Kino Shiho、Stickley Andrew、Arakawa Yuki、Saito Masashige、Saito Tami、Kondo Naoki
  • Journal Title: Psychogeriatrics Volume: 23 Pages: 475～486
  • DOI: 10.1111/psyg.12957
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Association of Blood Urea Nitrogen with Cardiovascular Diseases and All-Cause Mortality in USA Adults: Results from NHANES 1999-2006 (2023)
  • Author(s): Hong C, Zhu H, Zhou X, Zhai X, Li S, Ma W, Liu K, Shirai K, Sheerah HA, Cao J.
  • Journal Title: Nutrients Volume: 15(2) Pages: 461
  • DOI: 10.3390/nu15020461
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Occasions for laughter and dementia risk: Findings from a six-year cohort study (2023)
  • Author(s): Wang Y, Shirai K, Ohira T, Hirosaki M, Kondo N, Takeuchi K, Yamaguchi C, Tamada Y, Kondo K, Cadar D, Iso H.
  • Journal Title: Geriatr Gerontol Int Volume: 22(5) Pages: 392-398
  • DOI: 10.1111/ggi.14371
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Frequency of going outdoors and risk of poor oral health among older Japanese adults: a longitudinal cohort from the Japan Gerontological Evaluation Study (2023)
  • Author(s): Ishimura K, Sakaniwa R, Shirai K, Aida J, Takeuchi K, Kondo K, Iso H.
  • Journal Title: J Epidemiol Volume: - Pages: -
  • DOI: 10.2188/jea.JE20220221
  • Peer Reviewed
• [Journal Article] Sex- and age-specific impacts of smoking, overweight/obesity, hypertension, and diabetes mellitus in the development of disabling dementia in a Japanese population (2023)
  • Author(s): Tanaka M, Imano H, Hayama-Terada M, Muraki I, Shirai K, Yamagishi K, Okada T, Kiyama M, Kitamura A, Takayama Y, Iso H.
  • Journal Title: Environ Health Prev Med Volume: 28 Pages: 11
  • DOI: 10.1265/ehpm.22-00187
  • Peer Reviewed
• [Journal Article] Modifying Effect of Outdoor Recreational Activity on the Association Between Anger Expression and Cardiovascular Disease Risk: The Circulatory Risk in Communities Study (2023)
  • Author(s): Tezuka K, Kubota Y, Ohira T, Muraki I, Hayama-Terada M, Shimizu Y, Imano H, Shirai K, Okada T, Kiyama M, Iso H.
  • Journal Title: Psychosom Med Volume: 85(2) Pages: 182-187
  • DOI: 10.1097/PSY.0000000000001166
  • Peer Reviewed
• [Journal Article] Ambient PM(2.5), ozone and mortality in Chinese older adults: A nationwide cohort analysis (2005-2018) (2023)
  • Author(s): Zhang Y, Yin Z, Li S, Zhang JJ, Sun HZ, Liu K, Shirai K, Hu K, Qiu C, Liu X, Li Y, Zeng Y, Yao Y.
  • Journal Title: J Hazard Mater Volume: 454 Pages: 131539
  • DOI: 10.1016/j.jhazmat.2023.131539
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Body Mass Index and Mortality from Nonrheumatic Aortic Valve Disease among Japanese Men and Women (2023)
  • Author(s): Teramoto M, Yamagishi K, Cui R, Shirai K, Tamakoshi A, Iso H.
  • Journal Title: J Atheroscler Thromb Volume: 30(2) Pages: 150-159
  • DOI: 10.5551/jat.63452
  • Peer Reviewed
• [Journal Article] Laughter yoga as an enjoyable therapeutic approach for glycemic control in individuals with type 2 diabetes: A randomized controlled trial (2023)
  • Author(s): Hirosaki M, Ohira T, Wu Y, Eguchi E, Shirai K, Imano H, Funakubo N, Nishizawa H, Katakami N, Shimomura I, Iso H.
  • Journal Title: Front Endocrinol (Lausanne) Volume: 14 Pages: 1148468
  • DOI: 10.3389/fendo.2023.1148468
  • Peer Reviewed
• [Journal Article] Associations of different isomeric forms of serum lycopene with cardiovascular-disease and all-cause mortality (2023)
  • Author(s): Zhang Y, Zhai X, Chai H, Liu K, Ma W, Li S, Zeng J, Yang M, Zhou F, Zheng S, Wu X, Xiang B, Cao J, Eshak ES, Jiang C
  • Journal Title: Int J Vitam Nutr Res Volume: - Pages: -
  • DOI: 10.1024/0300-9831/a000775
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Arm Circumference, Arm-to-Waist Ratio in Relation to Cardiovascular and All- Cause Mortality among Patients with Diabetes Mellitus (2023)
  • Author(s): Xiao X, Yu X, Zhu H, Zhai X, Li S, Ma W, Ouyang M, Liu K, Eshak ES, Cao J
  • Journal Title: Nutrients Volume: 15(4) Pages: 961
  • DOI: 10.3390/nu15040961
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Associations of eicosapentaenoic acid and docosahexaenoic acid intakes with cardiovascular and all-cause mortality in patients with diabetes: Result from National Health and Nutrition Examination Survey 1999-2008 (2023)
  • Author(s): Huang N, Wang F, Li S, Zhai X, Ma W, Liu K, Sheerah HA, Cao J, Eshak ES
  • Journal Title: Front Cardiovasc Med Volume: 9 Pages: 1031168
  • DOI: 10.3389/fcvm.2022.1031168
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] A characteristic N-glycopeptide signature associated with diabetic cognitive impairment identified in a longitudinal cohort study (2023)
  • Author(s): Miura Y, Tsumoto H, Masui Y, Inagaki H, Ogawa M, Ideno Y, Kawakami K, Umezawa K, Kabayama M, Akagi Y, Akasaka H, Yamamoto K, Rakugi H, Ishizaki T, Arai Y, Ikebe K, Kamide K, Gondo Y, Endo T
  • Journal Title: Biochimica et Biophysica Acta: General Subjects Volume: 1867(4) Pages: 130316
  • DOI: 10.1016/j.bbagen.2023.130316
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Early- to late-life environmental factors and late-life global cognition in septuagenarian and octogenarians: The SONIC study (2023)
  • Author(s): Ishioka YL, Masui Y, Nakagawa T, Ogawa M, Inagaki H, Yasumoto S, Ikebe K, Kamide K, Arai Y, Ishizaki T, Gondo Y
  • Journal Title: Acta Psychologica Volume: 233 Pages: 103844
  • DOI: 10.1016/j.actpsy.2023.103844
  • Peer Reviewed
• [Journal Article] 生物学的加齢と適応：認知予備力とポジティビティ効果 (2023)
  • Author(s): 石岡良子, 権藤恭之
  • Journal Title: 老年精神医学雑誌 Volume: 34(2) Pages: 163-172
  • Peer Reviewed
• [Journal Article] Optimism and Longevity Among Japanese Older Adults (2022)
  • Author(s): Okuzono SS, Shiba K, Lee HH, Shirai K, Koga HK, Kondo N, Fujiwara T, Kondo K, Grodstein F, Kubzansky LD, Trudel-Fitzgerald C.
  • Journal Title: J Happiness Stud Volume: 23(6) Pages: 2581-2595
  • DOI: 10.1007/s10902-022-00511-8
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] The Association Between Living Area in Childhood and Respiratory Disease Mortality in Adulthood (2022)
  • Author(s): Iwasaki A, Teramoto M, Muraki I, Shirai K, Tamakoshi A, Iso H.
  • Journal Title: Int J Public Health Volume: 67 Pages: 1604778
  • DOI: 10.3389/ijph.2022.1604778
  • Peer Reviewed
• [Journal Article] Hobby engagement and risk of disabling dementia (2022)
  • Author(s): Matsumura T, Muraki I, Ikeda A, Yamagishi K, Shirai K, Yasuda N, Sawada N, Inoue M, Iso H, Brunner EJ, Tsugane S.
  • Journal Title: J Epidemiol Volume: - Pages: -
  • DOI: 10.2188/jea.JE20210489
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Pneumonia and subsequent risk of dementia: Evidence from the Japan Gerontological evaluation study (2022)
  • Author(s): Khairan P, Shirai K, Shobugawa Y, Cadar D, Saito T, Kondo K, Sobue T, Iso H.
  • Journal Title: Int J Geriatr Psychiatry Volume: 37(11) Pages: -
  • DOI: 10.1002/gps.5825
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Associations of dietary intakes of vitamins B(1) and B(3) with risk of mortality from CVD among Japanese men and women: the Japan Collaborative Cohort study (2022)
  • Author(s): Tang C, Eshak ES, Shirai K, Tamakoshi A, Iso H.
  • Journal Title: Br J Nutr Volume: 129(7) Pages: 1-8
  • DOI: 10.1017/S0007114522001209
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Mind-body therapies for older adults with dementia: a systematic review and meta-analysis (2022)
  • Author(s): Wang Y, Tang C, Fan X, Shirai K, Dong JY.
  • Journal Title: Eur Geriatr Med Volume: 13(4) Pages: 881-891
  • DOI: 10.1007/s41999-022-00639-z
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Evaluation of Complexity Measurement Tools for Correlations with Health-Related Outcomes, Health Care Costs and Impacts on Healthcare Providers: A Scoping Review (2022)
  • Author(s): Kaneko H, Hanamoto A, Yamamoto-Kataoka S, Kataoka Y, Aoki T, Shirai K, Iso H.
  • Journal Title: Int J Environ Res Public Health Volume: 19(23) Pages: 16113
  • DOI: 10.3390/ijerph192316113
  • Peer Reviewed
• [Journal Article] Ikigai and subsequent health and wellbeing among Japanese older adults: Longitudinal outcome-wide analysis (2022)
  • Author(s): Okuzono SS, Shiba K, Kim ES, Shirai K, Kondo N, Fujiwara T, Kondo K, Lomas T, Trudel-Fitzgerald C, Kawachi I, VanderWeele TJ.
  • Journal Title: Lancet Reg Health West Pac Volume: 21 Pages: 100391
  • DOI: 10.1016/j.lanwpc.2022.100391
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Daytime napping and risk of liver cancer: A large population-based prospective cohort study (2022)
  • Author(s): Arafa A, Eshak ES, Shirai K, Muraki I, Tamakoshi A, Iso H; JACC Study Group.
  • Journal Title: Ann Hepatol Volume: 28(2) Pages: 100877
  • DOI: 10.1016/j.aohep.2022.100877
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Dairy intake and the risk of pancreatic cancer: the Japan Collaborative Cohort Study (JACC Study) and meta-analysis of prospective cohort studies (2022)
  • Author(s): Arafa A, Eshak ES, Dong JY, Shirai K, Muraki I, Iso H, Tamakoshi A; JACC Study Group.
  • Journal Title: Br J Nutr Volume: 128(6) Pages: 1147-1155
  • DOI: 10.1017/S0007114521004232
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Impact of modifiable healthy lifestyle adoption on lifetime gain from middle to older age (2022)
  • Author(s): Sakaniwa R, Noguchi M, Imano H, Shirai K, Tamakoshi A, Iso H; JACC Study Group.
  • Journal Title: Age Ageing Volume: 51(5) Pages: afac080
  • DOI: 10.1093/ageing/afac080
  • Peer Reviewed
• [Journal Article] Positive psychological factors and the risk of pneumonia-associated mortality: Japan Collaborative Cohort Study (2022)
  • Author(s): Sumiyama A, Shirai K, Imano H, Eguchi E, Muraki I, Tamakoshi A, Iso H; for JACC Study Group.
  • Journal Title: J Psychosom Res Volume: 160 Pages: 110971
  • DOI: 10.1016/j.jpsychores.2022.110971
  • Peer Reviewed
• [Journal Article] Early-Adulthood Weight Change and Later Physical Activity in Relation to Cardiovascular and All-Cause Mortality: NHANES 1999-2014 (2022)
  • Author(s): Xiao X, Tang C, Zhai X, Li S, Ma W, Liu K, Kokoro S, Sheerah HA, Zhu H, Cao J.
  • Journal Title: Nutrients Volume: 14(23) Pages: 4974
  • DOI: 10.3390/nu14234974
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Effects of a laughter program on body weight and mental health among Japanese people with metabolic syndrome risk factors: a randomized controlled trial (2022)
  • Author(s): Funakubo N, Eguchi E, Hayashi R, Hirosaki M, Shirai K, Okazaki K, Nakano H, Hayashi F, Omata J, Imano H, Iso H, Ohira T.
  • Journal Title: BMC Geriatr Volume: 22(1) Pages: 361
  • DOI: 10.1186/s12877-022-03038-y
  • Peer Reviewed
• [Journal Article] The association between midlife living arrangement and psychiatrist-diagnosed depression in later life: who among your family members reduces the risk of depression? (2022)
  • Author(s): Ogawa K, Shirai K, Nozaki S, Shikimoto R, Sawada N, Mimura M, Iso H, Tsugane S; Japan Public Health Center-based Prospective Study Group.
  • Journal Title: Transl Psychiatry Volume: 12(1) Pages: 156
  • DOI: 10.1038/s41398-022-01880-7
  • Peer Reviewed
• [Journal Article] Purpose in life (Ikigai) and employment status in relation to cardiovascular mortality: the Japan Collaborative Cohort Study (2022)
  • Author(s): Miyazaki J, Shirai K, Kimura T, Ikehara S, Tamakoshi A, Iso H.
  • Journal Title: BMJ Open Volume: 12(10) Pages: e059725
  • DOI: 10.1136/bmjopen-2021-059725
  • Peer Reviewed
• [Journal Article] Dairy Intake and the Risk of Esophageal Cancer: The JACC Study (2022)
  • Author(s): Arafa A, Eshak ES, Shirai K, Muraki I, Tamakoshi A, Iso H.
  • Journal Title: J Epidemiol Volume: - Pages: -
  • DOI: 10.2188/jea.JE20220037
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] The number of leisure-time activities and risk of functional disability among Japanese older population: the JAGES cohort (2022)
  • Author(s): Fuji Y, Sakaniwa R, Shirai K, Saito T, Ukawa S, Iso H, Kondo K.
  • Journal Title: Prev Med Rep Volume: - Pages: 101741
  • DOI: 10.1016/j.pmedr.2022.101741
  • Peer Reviewed
• [Journal Article] Perspectives of Healthcare Providers towards Remote Medical Interpreting Services in Japan (2022)
  • Author(s): Saeki S, Minamitani K, Iwaoka F, Shirai K.
  • Journal Title: Healthcare (Basel) Volume: 11(1) Pages: 112
  • DOI: 10.3390/healthcare11010112
  • Peer Reviewed
• [Journal Article] Association between Dietary Manganese Intake and Mortality from Cardiovascular Disease in Japanese Population: The Japan Collaborative Cohort Study (2022)
  • Author(s): Meishuo O, Eshak ES, Muraki I, Cui R, Shirai K, Iso H, Tamakoshi A.
  • Journal Title: J Atheroscler Thromb Volume: 29(10) Pages: 1432-1447
  • DOI: 10.5551/jat.63195
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Association between outdoor artificial light at night and sleep duration among older adults in China: A cross-sectional study (2022)
  • Author(s): Hu K, Li W, Zhang Y, Chen H, Bai C, Yang Z, Lorenz T, Liu K, Shirai K, Song J, Zhao Q, Zhao Y, Zhang JJ, Wei J, Pan J, Qi J, Ye T, Zeng Y, Yao Y.
  • Journal Title: Environ Res Volume: 212(PtB) Pages: 113343
  • DOI: 10.1016/j.envres.2022.113343
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Association between Serum Uric Acid and Impaired Endothelial Function: The Circulatory Risk in Communities Study (2022)
  • Author(s): Tang J, Liu K, Eshak ES, Cui R, Sakaniwa R, Imano H, Dong JY, Iso H
  • Journal Title: J Atheroscler Thromb Volume: 29(10) Pages: 1534-1546
  • DOI: 10.5551/jat.63199
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Association of lung function with the risk of cardiovascular diseases and all-cause mortality in patients with diabetes: Results from NHANES III 1988-1994 (2022)
  • Author(s): Huang N, Tang C, Li S, Ma W, Zhai X, Liu K, Sheerah HA, Cao J
  • Journal Title: Front Cardiovasc Med Volume: 9 Pages: 976817
  • DOI: 10.3389/fcvm.2022.976817
  • Peer Reviewed
• [Journal Article] Cognition, function, and prevalent dementia in centenarians and near-centenarians: An individual participant data (IPD) meta-analysis of 18 studies (2022)
  • Author(s): Leung Y, Barzilai N, Batko-Szwaczka A, Beker N, Boerner K, Brayne C, Brodaty H, Cheung KSL, Corrada MM, Crawford JD, Galbussera AA, Gondo Y, Holstege H, Hulsman M,
  • Journal Title: Alzheimer's & Dementia Volume: - Pages: 1‐11
  • DOI: 10.1002/alz.12828
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Associations between salivary testosterone levels and cognitive function among 70-year-old Japanese elderly: A cross-sectional analysis of the SONIC study (2022)
  • Author(s): Hirokawa K, Kasuga A, Matsumoto K, Omori Y, Masui Y, Nakagawa T, Ogawa M, Ishioka Y, Inagaki H, Ikebe K, Arai Y, Ishizaki T, Kamide K, Gondo Y
  • Journal Title: Geriatrics & Gerontology International Volume: 22 Pages: 1040-1046
  • DOI: 10.1111/ggi.14504
  • Peer Reviewed
• [Journal Article] Cognitive Reserve and Cognitive Functioning among Oldest Old Adults: Findings from the Georgia Centenarian Study (2022)
  • Author(s): Martin P, Gondo Y, Lee G, Woodard JL, Miller LS, Poon LW
  • Journal Title: Experimental Aging Research Volume: 5 Pages: 1‐13
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Physical performance reference values for Japanese oldest old: a SONIC study (2022)
  • Author(s): Matsumoto K, Gondo Y, Masui Y, Yasumoto S, Yoshida Y, Ikebe K, Arai Y, Kabayama M, Kamide K, Akasaka H and Ishizaki T
  • Journal Title: BMC Geriatrics Volume: 22 Pages: 748
  • Peer Reviewed
• [Journal Article] Construct Validity of a New Health Assessment Questionnaire for the National Screening Program of Older Adults in Japan: The SONIC Study (2022)
  • Author(s): Ishizaki T, Masui Y, Nakagawa T, Yoshida Y, Ishioka YL, Hori N, Inagaki H, Ito K, Ogawa M, Kabayama M, Kamide K, Ikebe K, Arai Y and Gondo Y
  • Journal Title: International Journal of Environmental Research and Public Health Volume: 19(16) Pages: 10330
  • DOI: 10.3390/ijerph191610330
  • Peer Reviewed
• [Journal Article] Older Adults’ Resilience Against Impact of Lifestyle Changes During the COVID-19 Pandemic (2022)
  • Author(s): Kasuga A, Yasumoto S, Nakagawa T, Ishioka Y, Kikuchi A, Inagaki H, Ogawa M, Hori N, Masui Y, Choe H, Muto H, Kabayama M, Godai K, Ikebe K, Kamide K, Ishizaki T, and Gondo Y
  • Journal Title: Gerontology and Geriatric Medicine Volume: 8 Pages: 1-6
  • DOI: 10.1177/23337214221116226
  • Peer Reviewed
• [Journal Article] Association of personality traits with polypharmacy among community-dwelling older adults in Japan: a cross-sectional analysis of data from the SONIC study (2022)
  • Author(s): Yoshida Y, Ishizaki T, Masui Y, Arai Y, Inagaki H, Ogawa M, Yasumoto S, Iwasa H, Kamide K, Rakugi H, Ikebe K, Gondo Y
  • Journal Title: BMC Geriatrics Volume: 22(1) Pages: 372
  • Peer Reviewed
• [Journal Article] Factors Related to Preventive Behaviors against a Decline in Physical Fitness among Community-Dwelling Older Adults during the COVID-19 Pandemic: A Qualitative Study (2022)
  • Author(s): Kimura Y, Akasaka H, Takahashi T, Yasumoto S, Kamide K, Ikebe K, Kabayama M, Kasuga A, Rakugi H and Gondo Y
  • Journal Title: International Journal of Environmental Research and Public Health Volume: 19(10) Pages: 6008
  • DOI: 10.3390/ijerph19106008
  • Peer Reviewed
• [Journal Article] Predictive factors for tooth loss in older adults vary according to occlusal support: A 6-year longitudinal survey from the SONIC study (2022)
  • Author(s): Sato H, Hatta K, Murotani Y, Takahashi T, Gondo Y, Kamide K, Masui Y, Ishizaki T, Kabayama M, Ogata S, Matsuda K, Mihara Y, Fukutake M, Hagino H, Higashi K, Akema S, Kitamura M, Murakami S, Maeda Y, Ikebe K
  • Journal Title: Journal of Dentistry Volume: 121 Pages: 104088
  • DOI: 10.1016/j.jdent.2022.104088
  • Peer Reviewed
• [Journal Article] Self-monitoring home blood pressure in community dwelling older people: Age differences in white-coat and masked phenomena and related factors -The SONIC Study- (2022)
  • Author(s): Tuo J, Godai K, Kabayama M, Akagi Y, Akasaka H, Takami Y, Takeya Y, Yamamoto K, Sugimoto K, Yasumoto S, Masui Y, Arai Y, Ikebe K, Gondo Y, Ishizaki T, Rakugi H, Kamide K
  • Journal Title: International Journal of Hypertension Volume: - Pages: 1-9
  • DOI: 10.1155/2022/5359428
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Decline of oral functions in old-old adults and their relationship with age and sex: The SONIC study (2022)
  • Author(s): Hatta K, Murotani Y, Takahashi T, Gondo Y, Kamide K, Masui Y, Ishizaki T, Ogata S, Matsuda KI, Mihara Y, Fukutake M, Nishimura Y, Hagino H, Higashi K, Maeda Y, Ikebe K
  • Journal Title: Journal of the American Geriatrics Society Volume: 70 Pages: 541-548
  • Peer Reviewed
• [Journal Article] Alcohol drinking patterns have a positive association with cognitive function among older people: a cross?sectional study (2022)
  • Author(s): Akagi Y, Kabayama M, Gondo Y, Masui Y, Yasumoto S, Klinpudtan N, Srithumsuk W, Godai K, Ikebe K, Akasaka H, Yokoyama S, Nozato Y, Takami Y, Takeya Y, Yamamoto K, Sugimoto K, Arai Y, Inagaki H, Ishizaki T, Rakugi H and Kamide K
  • Journal Title: BMC Geriatrics Volume: 22 Pages: 158
  • DOI: 10.1186/s12877-022-02852-8
  • Peer Reviewed
• [Journal Article] Association between protein intake and changes in renal function among Japanese community-dwelling older people: The SONIC study (2022)
  • Author(s): Sekiguchi T, Kabayama M, Ryuno H, Tanaka K, Kiyoshige E, Akagi Y, Godai K, Sugimoto K, Akasaka H, Takami Y, Takeya Y, Yamamoto K, Yasumoto S, Masui Y, Ikebe K, Gondo Y, Arai Y, Ishizaki T, Rakugi H and Kamide K
  • Journal Title: Geriatrics & Gerontology International Volume: - Pages: 1-6
  • DOI: 10.1111/ggi.14355
  • Peer Reviewed
• [Journal Article] Factors associated with psychological well-being among nonagenarians: Well-being in the era of 100 years of life (2022)
  • Author(s): Ito K, Okamura T, Awata S, Gondo Y, Masui Y, Inagaki H, Kamide K, Ikebe K, Arai Y, Ishizaki T
  • Journal Title: Geriatrics & Gerontology International Volume: - Pages: 1-3
  • DOI: 10.1111/ggi.14359
  • Peer Reviewed
• [Journal Article] 加齢に伴って認知機能は低下するのか (2022)
  • Author(s): 権藤恭之
  • Journal Title: 保健の科学 Volume: 64(8) Pages: 521-525
  • Peer Reviewed
• [Journal Article] Functional disability trajectories at the end of life among Japanese older adults: Findings from the JAGES (2022)
  • Author(s): Saito J, Murayama H, Ueno T, Saito M, Haseda M, Saito T, Kondo K, Kondo N
  • Journal Title: Age & Ageing Volume: 51(11) Pages: afac260
  • DOI: 10.1093/ageing/afac260
  • Peer Reviewed
• [Presentation] 社会関係とWELL-BEING（幸福・健康）：ポジティブ心理要因と健康の社会的決定要因 (2023)
  • Author(s): 白井 こころ、澤田康幸、内田 由紀子、小林 正弥、原田 謙、近藤 克則
  • Organizer: 第3回日本社会関係学会総会
  • Invited
• [Presentation] 飲酒習慣と腸内細菌叢との関連：CIRCS研究 (2023)
  • Author(s): 長尾 匡則、細見 晃司 、朴 鐘旭 、白井 こころ 、舟久保 徳美 、高田 碧 、山岸 良匡 、清水 悠路 、村木 功 、今野 弘規 、岡田 武夫 、木山 昌彦 、村上 晴香 、南里 妃名子 、水口 賢司 、宮地 元彦 、國澤 純 、磯 博康、大平 哲也
  • Organizer: 第33回日本疫学会学術総会
• [Presentation] 共分散構造分析モデリングによるフレイルの関連因子の要因分析 (2023)
  • Author(s): 孫 智超、白井 こころ、北村 明彦 、平井 啓 、羽山 実奈 、高山 佳洋 、近藤 克則
  • Organizer: 第33回日本疫学会学術総会
• [Presentation] 中年期と高齢前期における死亡リスクの検討 (2023)
  • Author(s): 松村 拓実、北村 明彦、羽山 実奈、高山 佳洋、田中 麻 理、村木 功、白井 こころ、今野 弘規、高田 碧、清水 悠路、岡田 武夫、木山 昌彦、磯 博康
  • Organizer: 第33回日本疫学会学術総会
• [Presentation] 地域のスポーツグループ参加割合と全死因・死因別死亡: 7年間のJAGESマルチレベル縦断研究 (2023)
  • Author(s): 辻大士、岡田栄作、 斉藤雅茂、 金森悟、宮國康弘、花里真道、近藤克則、尾島俊之
  • Organizer: 第33回日本疫学会学術総会
• [Presentation] 人生最晩年における心理的適応の様相 (2023)
  • Author(s): 権藤恭之
  • Organizer: 日本発達心理学会第34回大会
  • Invited
• [Presentation] 外出好き/家好きで介護開始後の主感的健康感悪化リスクは異なるか？ (2023)
  • Author(s): 水田明子, 尾島俊之, 斎藤民, 近藤克則
  • Organizer: 第33回日本疫学会学術総会
• [Presentation] 高齢者にやさしいまちは家族介護負担による抑うつを軽減するか：JAGES (2023)
  • Author(s): 野口泰司, 藤原聡子, 鄭丞媛, 井手一茂, 斎藤民, 近藤克則, 尾島俊之
  • Organizer: 第33回日本疫学会学術総会
• [Presentation] 死亡前3年間の介護サービス給付費のトラジェクトリ：9年間の縦断研究 (2023)
  • Author(s): 渡邉良太, 斉藤雅茂, 上野貴之, 井手一茂, 辻大士, 斎藤民, 近藤克則
  • Organizer: 第33回日本疫学会学術総会
• [Presentation] 地域在住高齢者における関節リウマチの診断とフレイル、社会的背景に関する検討：JAGES横断研究 (2023)
  • Author(s): 小嶋雅代, 渡邉良太, 安岡実佳子, 竹内研時, 斎藤民, 寺部健哉, 小嶋俊久, 尾島俊之, 近藤克則
  • Organizer: 第33回日本疫学会学術総会
• [Presentation] ストレス対処能力（SOC）と要介護認知症発症 との関連：JAGES プロジェクト (2022)
  • Author(s): 李嘉琦、白井こころ、 磯博康、 近藤克則
  • Organizer: 第81回公衆衛生学会
• [Presentation] 中年期・前期高齢者の朝食欠食と将来の要介護認 知症発症との関連 (2022)
  • Author(s): 田中麻理 、今野弘規、羽山実奈、村木功、白井こころ、山岸良匡、岡田武夫、木山昌彦、北村明彦、髙山佳洋、磯博康
  • Organizer: 第81回公衆衛生学会
• [Presentation] 中年期の同居家族と老年期における精神科医に診断されたうつ病との関連性：多目的コホート研究佐久こころの検診研究 (2022)
  • Author(s): 小川 憲人, 今野 弘規, 白井 こころ, 澤田 典絵, 磯 博康
  • Organizer: 第81回公衆衛生学会
• [Presentation] 子どもの頃の逆境体験と青年期の幸福感，主観的健康感，抑うつとの関連 (2022)
  • Author(s): 永久保涼子、辻大士
  • Organizer: 日本学校保健学会第68回学術大会
• [Presentation] Reality of the COVID-19 pandemic impact on older adult’s life in Japan (2022)
  • Author(s): Gondo Y., Kasuga A. & Choe H
  • Organizer: KGS International Symposium
  • Int'l Joint Research / Invited
• [Presentation] Behavioral characteristics of older people under COVID-19 pandemic; a 3-year longitudinal study (2022)
  • Author(s): Gondo Y. & Kasuga A
  • Organizer: 1st cycle INNOVCARE Webinar no.3
  • Int'l Joint Research
• [Presentation] 「学際的」な老年学研究のこれまでとこれから (2022)
  • Author(s): 権藤恭之
  • Organizer: 日本老年社会科学会第64回大会
  • Invited
• [Presentation] 生涯発達における発達の最適化とWell-being: 成人期・老年期の適応的な発達と支援 (2022)
  • Author(s): 権藤恭之
  • Organizer: 日本発達心理学会第33回大会
  • Invited