Development of synthetic photo-functional molecules for medical applications

2014 Fiscal Year Final Research Report

• Project/Area Number: 22000006
• Research Category: Grant-in-Aid for Specially Promoted Research
• Allocation Type: Single-year Grants
• Review Section: Science and Engineering; Chemistry
• Research Institution: The University of Tokyo
• Principal Investigator: NAGANO Tetsuo 東京大学, 創薬オープンイノベーションセンター, 客員教授 (20111552)
• Co-Investigator(Kenkyū-buntansha): HIRATA Yasunobu 東京大学, 医学部附属病院, 特任准教授 (70167609) ; HANAOKA Kenjiro 東京大学, 大学院薬学系研究科, 准教授 (70451854) ; TERAI Takuya 東京大学, 大学院薬学系研究科, 助教 (00508145) ; UENO Tasuku 東京大学, 大学院薬学系研究科, 助教 (60462660) ; KOMATSU Toru 東京大学, 大学院薬学系研究科, 助教 (40599172) ; TAKAHASHI Masao 東京大学, 医学部附属病院, 助教 (00447418)
• Project Period (FY): 2010-04-21 – 2015-03-31
• Keywords: 生体機能関連化学 / ケミカルバイオロジー / 分子イメージング

Outline of Final Research Achievements

Our group has studied on fluorescent probes, which change their fluorescence properties upon recognition of target molecules, and other photofunctional molecules in the last 20 years. In this project, we performed both basic and applied research regarding photofunctional molecules, from the development of novel fluorescent molecules to in vivo cancer imaging. We also developed useful imaging technologies for drug discovery, as well as MRI contrast reagents and photosensitizers.

Free Research Field

生体関連化学