Molecular studies of motor learning and maturation of the cerebellar network

2014 Fiscal Year Final Research Report

• Project/Area Number: 22220005
• Research Category: Grant-in-Aid for Scientific Research (S)
• Allocation Type: Single-year Grants
• Research Field: Neuroscience in general
• Research Institution: Osaka Bioscience Institute
• Principal Investigator: NAKANISHI Shigetada 公益財団法人大阪バイオサイエンス研究所, システムズ生物学部門, 所長 (20089105)
• Co-Investigator(Kenkyū-buntansha): FUNABIKI Kazuo (公財)大阪バイオサイエンス研究所, システムズ生物学部門, 研究副部長 (00301234) ; OKAZAWA Makoto (公財)大阪バイオサイエンス研究所, システムズ生物学部門, 研究員 (40414130) ; YAWATA Satoshi (公財)大阪バイオサイエンス研究所, システムズ生物学部門, 研究員 (90455246) ; WADA Norio (公財)大阪バイオサイエンス研究所, システムズ生物学部門, 研究員 (90525958)
• Project Period (FY): 2010-04-01 – 2015-03-31
• Keywords: 小脳 / 運動記憶 / 神経回路 / 神経成熟 / 細胞内シグナル

Outline of Final Research Achievements

This project is directed to explore how motor learning is acquired, expressed and stored in the cerebellar network and how the functional cerebellar network is organized during development in an activity-dependent manner. The studies using a novel, pathway-specific neurotransmission blocking technique disclosed that two forms of motor learning, eyeblink conditioning and optokinetic reflex, are induced by distinct circuit-dependent neural plasticity. The studies also identified the key signaling mechanism and the master transcription factor responsible for cerebellar maturation and demonstrated that the cerebellar maturation is controlled by convergence of the activity-dependent and extracellular signaling mechanisms.

Free Research Field

総合領域