Development of a Nano-Micro Platform for Tissue Engineering Applications

2014 Fiscal Year Final Research Report

• Project/Area Number: 22220008
• Research Category: Grant-in-Aid for Scientific Research (S)
• Allocation Type: Single-year Grants
• Research Field: Biomedical engineering/Biological material science
• Research Institution: The University of Tokyo
• Principal Investigator: IKUTA Koji 東京大学, 先端科学技術研究センター, 教授 (90212745)
• Co-Investigator(Renkei-kenkyūsha): TATSUMI Hitoshi 名古屋大学, 大学院医学研究科, 准教授 (20171720) ; HAYASHI Shuji 名古屋大学, 大学院医学研究科, 教授 (30218573) ; IKEUCHI Masashi 東京大学, 先端科学技術研究センター, 助教 (90377820) ; INOUE Yoshinori 東京大学, 先端科学技術研究センター, 特任助教 (20402505)
• Project Period (FY): 2010-04-01 – 2015-03-31
• Keywords: 医用マイクロマシン / 再生医療 / 自動培養 / スキャフォールド / 光駆動マイクロロボット / 細胞操作

Outline of Final Research Achievements

Tissue engineering is a research field thriving at an immense speed globally. In order to boost tissue engineering to a clinically applicable level, it is inevitable for low-cost automated tissue regeneration system to be developed, not at the cellular level, but at the tissue/organ level. We aim to contribute to the field by integrating originally developed root technologies such as 3-D nano-fabrication, micro-actuators, super-small force sensing, and nano-functional materials. The developed prototype system has deformable micro-wells arrayed 10x10 in 1cm square, and each well can be controlled independently by pneumatic actuation. By using this prototype, embryonic bodies of stem cells (human iPSc, mouse ESc and etc.) were formed, cultured, differentiated and sorted in a palm-sized closed device without manual works.

Free Research Field

医用マイクロ・ナノマシン