2014 Fiscal Year Final Research Report
Signal toxicity mediated through nuclear receptors of new generation bisphenols
| Project/Area Number |
22221005
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| Research Category |
Grant-in-Aid for Scientific Research (S)
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| Allocation Type | Single-year Grants |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NOSE Takeru 九州大学, 大学院理学研究院, 教授 (10301334)
SHIMOHIGASHI Miki 福岡大学, 理学部, 講師 (60078590)
MATSUSHIMA Ayami 九州大学, 大学院理学研究院, 准教授 (60404050)
NAKAGAWA Hiroyuki 福岡大学, 理学部, 教授 (80274562)
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| Co-Investigator(Renkei-kenkyūsha) |
LIU Xiaohui 九州大学, 大学院理学研究院, 助教 (60596849)
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| Research Collaborator |
巣山 慶太郎 , 学振特別研究員
池田 伸 , 学振特別研究員
西村 裕一 , 学振特別研究員
松尾 文香 , 学振特別研究員
松山 祐昂 , 学振特別研究員
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| Project Period (FY) |
2010-04-01 – 2015-03-31
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| Keywords | 有害化学物質 / 内分泌かく乱物質 / ビスフェノールＡ / 核内受容体 / シグナル毒性 / 新世代ビスフェノール |
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| Outline of Final Research Achievements |
As to bisphenol A (BPA) and its substitutes, or so-called new-generation bisphenols, the aim of this project is to clarify the molecular mechanisms of their signal toxicity such as low-dose effects and endocrine disrupting actions mediated through the nuclear receptors. Consequently, it was demonstrated that (i) BPA exposure causes a hypoactivity in mice, while hyperactivity in the fruit fly Drosophila, due to the various defects in clock genes, (ii) BPA’s high estrogen-like activity is a low-dose effect as a result of cooperative work between ER and highly constitutively active nuclear receptors such as ERRs, and (iii) differential receptor responses, namely, agonist or antagonist activity of bisphenol AF is due to the molecular interaction disparity between the ERs and the coactivators.
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| Free Research Field |
生物化学
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