2014 Fiscal Year Final Research Report
A novel approach for the understanding of basic structure and behavior of human chromosomes
| Project/Area Number |
22221009
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| Research Category |
Grant-in-Aid for Scientific Research (S)
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| Allocation Type | Single-year Grants |
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| Research Field |
Genome biology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
伊藤 武彦 東京工業大学, 生命理工学研究科, 教授 (90501106)
広田 亨 公益財団法人がん研究会, 部長 (50421368)
須谷 尚史 東京大学, 分子細胞生物学研究所, 助教 (30401524)
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| Project Period (FY) |
2010-04-01 – 2015-03-31
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| Keywords | 染色体 / ゲノム構造 / 染色体構造 / 染色体機能 / 転写 / 次世代シークエンサー / タンパクプロファイル解析 / SMCタンパク |
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| Outline of Final Research Achievements |
We have built up the informatics system to explore human chromosome dynamics by Next Generation Sequencer Based Technology. Then by using this technology we have analyzed chromosome behavior during cell cycle, aging, and in cell line established from developmental disease patient. Our main achievements can be summarized as follows. 1) Discovery of cohesin deacetylase and its function during cell cycle, 2) Identification of cohesin as an essential component that link chromosome high order structure and transcriptional elongation, 3) identification of condensin's role as a masker of R-loop during mitosis, and 4) Establishment of new chromosomal informatics system (DROMPA) to understand chromosome dynamics.
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| Free Research Field |
ゲノム構造学
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