Analysis of host cellular transcriptional network induced by mononegavirus infection.

2015 Fiscal Year Final Research Report

• Project/Area Number: 22228005
• Research Category: Grant-in-Aid for Scientific Research (S)
• Allocation Type: Single-year Grants
• Research Field: Basic veterinary science/Basic zootechnical science
• Research Institution: The University of Tokyo
• Principal Investigator: KAI CHIEKO 東京大学, 医科学研究所, 教授 (10167330)
• Co-Investigator(Kenkyū-buntansha): YONEDA MISAKO 東京大学, 医科学研究所, 准教授 (40361620) ; SATO HIROKI 東京大学, 医科学研究所, 助教 (50418654)
• Co-Investigator(Renkei-kenkyūsha): HAYASHIZAKI YOSHIHIDE 独立行政法人理化学研究所, オミックス基盤研究領域, 領域長 (70192705)
• Project Period (FY): 2010-04-01 – 2016-03-31
• Keywords: モノネガウイルス / モービリウイルス / 転写制御 / CAGE / 病原性 / 持続感染

Outline of Final Research Achievements

In this work, we revealed transcriptional regulatory network induced by infection of morbilliviruses using a novel technique and bioinformatics analysis. As to highly pathogenic morbilliviruses and Nipah virus, which belong to the order mononegavirus, we analyzed the interaction between viral and cellular proteins and their post-translational modifications after infection, and revealed consequent influence on the virus life cycle and pathogenicity. In addition, we generated Tg mice expressing virus N protein as a model of persistent infection, and clarified a series of expression mechanisms of the unique pathogenicity.

Free Research Field

農学