2014 Fiscal Year Final Research Report
KLF network in chronic diseases and cancer
| Project/Area Number |
22229006
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| Research Category |
Grant-in-Aid for Scientific Research (S)
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| Allocation Type | Single-year Grants |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | The University of Tokyo |
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Principal Investigator |
NAGAI Ryozo 東京大学, 医学部附属病院, 名誉教授 (60207975)
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| Co-Investigator(Kenkyū-buntansha) |
MANABE Ichiro 東京大学, 医学部附属病院, 講師 (70359628)
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| Project Period (FY) |
2010-04-01 – 2015-03-31
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| Keywords | 転写因子 / 動脈硬化 / 糖尿病 / 慢性腎臓病 / 心不全 / メタボリックシンドローム / がん |
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| Outline of Final Research Achievements |
The Kruppel-like factor family consists of 17 zinc-finger-type transcription factors. This project aimed to elucidate pathological roles of KLF5 and KLF6 in cardiovascular, metabolic, and renal diseases and cancer. We found that KLF6 expressed in cardiomyocytes and KLF5 expressed in cardiac fibroblasts control cardiac responses to stress, such as cardiac hypertrophy and fibrosis. KLF6 is also important for controlling aortic inflammation. In kidneys KLF5 controls renal inflammation, which underlies chronic kidney disease. KLF5 also control intestinal stem cell function and associates with colon cancer. The mechanisms and pathways identified in this project would be attractive targets for the development of new therapeutic and diagnostic strategies.
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| Free Research Field |
内科学
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