2013 Fiscal Year Final Research Report
Mechanisms of the development of neuronal cell community in the central nervous system
| Project/Area Number |
22240041
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Keio University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
SAKAKIBARA Yasubumi 慶應義塾大学, 理工学部, 教授 (10287427)
TABATA Hidenori 愛知県心身障害者コロニー発達障害研究所, 神経制御学部, 室長 (80301761)
ARAMAKI Michihiko 慶應義塾大学, 医学部, 特任助教 (20338099)
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| Project Period (FY) |
2010-04-01 – 2014-03-31
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| Keywords | 大脳皮質 / 発生・分化 / 細胞移動 |
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| Research Abstract |
We have searched for molecules that regulate the patterns of neuronal production in the subventricular zone (SVZ)/multipolar cell accumulation zone (MAZ) of the developing mouse cerebral cortex. As the results of functional assays and comparative genomic analyses, we identified some important candidates that could change the number of proliferative neuronal progenitors in the SVZ. We also have found multiple receptors and ligands that could affect the behavior of multipolar cells in the MAZ. Finally, we show that the behavior of the multipolar cells in the MAZ is controlled through the PI(3,4)P2-Lamellipodin-Ena/VASP-actin system.
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Research Products
(51 results)
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[Journal Article] RP58 regulates the multipolar-bipolar transition of newborn neurons in the developing cerebral cortex2013
Author(s)
Chiaki Ohtaka-Maruyama, Shinobu Hirai, Akiko Miwa, Julian lk-Tsen Heng, Hiroshi Shitara, Rie Ishii, Choji Taya, Hitoshi Kawano, Masataka Kasai, Kazunori Nakajima, and Haruo Okado
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Journal Title
Cell Reports
Volume: 3(2)
Pages: 1-14
DOI
Peer Reviewed
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[Journal Article] Dab1-mediated colocalization of multi-adaptor protein CIN85 with Reelin-receptors, ApoER2 or VLDLR, in neurons2013
Author(s)
Takahiro Fuchigami, Yutaka Sato1, Yuya Tomita1, Tetsuya Takano, Shin-ya Miyauchi, Yukinori Tsuchiya, Taro Saito, Ken-ichiro Kubo, Kazunori Nakajima, Mitsunori Fukuda, Mitsuharu Hattori, and Shin-ichi Hisanaga
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Journal Title
Genes to Cells
Volume: 18(5)
Pages: 410-24
Peer Reviewed
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[Journal Article] Cellular composition and organization of the subventricular zone and rostral migratory stream in the adult and neonatal common marmoset brain2011
Author(s)
Kazunobu Sawamoto, Yuki Hirota, Clara Alfaro-Cervello, Mario Soriano-Navarro, Xiaoping He, Yoshika Hayakawa-Yano, Masayuki Yamada, Keigo Hikishima, Hidenori Tabata, Akio Iwanami, Kazunori Nakajima, Yoshiaki Toyama, Toshio Itoh, Arturo Alvarez-Buylla, Jose Manuel Garcia-Verdugo, and Hideyuki Okano
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Journal Title
J. Comp. Neurol
Volume: 519(4)
Pages: 690-713
DOI
Peer Reviewed
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[Journal Article] Neural crest-derived stem cells migrate and differentiate into cardiomyocytes after myocardial infarction2011
Author(s)
Yuichi Tamura, Keisuke Matsumura, Motoaki Sano, Hidenori Tabata, Kensuke Kimura, Masaki Ieda, Takahide Arai, Yohei Ohno, Hideaki Kanazawa, Shinsuke Yuasa, Ruri Kaneda, Shinji Makino, Kazunori Nakajima, Hideyuki Okano, and Keiichi Fukuda
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Journal Title
Arterioscler. Thromb. Vasc. Biol
Volume: 31(3)
Pages: 582-589
DOI
Peer Reviewed
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[Journal Article] DISC1-dependent switch from progenitor proliferation to migration in the developing cortex2011
Author(s)
Koko Ishizuka, Atsushi Kamiya, Edwin C. Oh, Hiroaki Kanki, Saurav Seshadri, Jon F. Robinson, Hannah Murdoch, Allan J. Dunlop, Ken-ichiro Kubo, Keiko Furukori, Beverly Huang, Mariela Zeledon, Akiko Hayashi-Takagi, Hideyuki Okano, Kazunori Nakajima, Miles D. Houslay, Nicholas Katsanis, and Akira Sawa
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Journal Title
Nature
Volume: 473(7345)
Pages: 92-96
DOI
Peer Reviewed
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[Journal Article] Migration defects by DISC1 knockdown in C57BL/6, 129X1/SvJ, and ICR strains via in utero gene transfer and virus-mediated RNAi2010
Author(s)
Ken-ichiro Kubo, Kenji Tomita, Asuka Uto, Keisuke Kuroda, Saurav Seshadri, Jared S. Cohen, Kozo Kaibuchi, Atsushi Kamiya, and Kazunori Nakajima
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Journal Title
Biochem. Biophys. Res. Commun
Volume: 400(4)
Pages: 631-637
DOI
Peer Reviewed
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[Journal Article] Cdk5 phosphorylation of ErbB4 is required for tangential migration of cortical interneurons
Author(s)
Sonja Rakić, Shigeaki Kanatani, David Hunt, Clare Faux, Anna Cariboni, Francesca Chiara, Shabana Khan, Olivia Wansbury, Beatrice Howard, Kazunori Nakajima, Margareta Nikolić, and John G
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Journal Title
Parnavelas. Cereb. Cortex
Volume: (in press)
DOI
Peer Reviewed
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[Remarks] 仲嶋一範. "動く細胞たちが織りなす脳の形づくり". 学校法人桐朋学園 桐朋中学・高等学校, 国立, 2013年11月19日(アウトリーチ講演活動)
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[Remarks] 仲嶋一範. "記念講演 : 脳ができるときの神経細胞たちの振る舞い".「めんたるぷれい」全国指導者研修大会, ワイズ企画(知能教育教材出版), 東京, 2013年8月6日(アウトリーチ講演活動)
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[Remarks] 仲嶋一範. "進化の最高傑作"大脳皮質の形づくり(高校1年生向け).栄光学園, 鎌倉, 2011年2月9日(アウトリーチ講演活動)
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[Remarks] 仲嶋一範. 動く細胞たちが作る脳という細胞社会 - 正常とその"破綻"- (一般向け公開). 栄光学園, 鎌倉, 2011年2月9日(アウトリーチ講演活動)
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[Remarks] 仲嶋一範. NHK ワールド TV : Science View「The Leading Edge : Shape Shifting Neurons」2012年8月31日(テレビ出演での研究紹介)
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[Remarks] 仲嶋一範. NHK サイエンスZERO「シリーズ細胞の世界④ 見えた!神経細胞の変幻自在」2011年7月30日(テレビ出演での研究紹介)
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[Remarks] 雑誌, 新聞, インターネット上での紹介Nature, Newton, 日刊工業新聞, 週刊科学新聞, 日経産業新聞, 化学工業日報等, 及びインターネット上の多くのサイトで紹介.
