Comprehensive study on optimum flow condition of total artificial heart from the view point of microcirculation

2013 Fiscal Year Final Research Report

• Project/Area Number: 22240054
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Biomedical engineering/Biological material science
• Research Institution: The University of Tokyo
• Principal Investigator: KOU Imachi 東京大学, 医学(系)研究科(研究院), 名誉教授 (10010076)
• Co-Investigator(Renkei-kenkyūsha): ABE Yusuke 東京大学, 大学院・医学系研究科, 准教授 (90193010) ; ISOYAMA Takashi 東京大学, 大学院・医学系研究科, 講師 (20302789) ; SAITO Itsuro 東京大学, 大学院・医学系研究科, 特任研究員 (80334225)
• Research Collaborator: VASKU Jaromir チェコマサリク大学, 医学部, 名誉教授 ; DOBSAK Petr チェコマサリク大学, 医学部, 教授 ; ONO Toshiya 東京大学, 大学院・医学系研究科, 技術専門職員 ; INOUE Yusuke 東京大学, 大学院・工学系研究科, 特任研究員 (80611079)
• Project Period (FY): 2010-04-01 – 2014-03-31
• Keywords: 血行動態 / 微小循環 / 人工心臓 / 顕微鏡

Research Abstract

It was succeeded to develop the following research tools to clarify the influences of flow dynamic states of total artificial heart such as pulsatile flow, continuous flow, etc. on microcirculation of the living body; 1) Undulation pump total artificial heart that was enough compact to be implanted into the chest cavity of a goat weighing 40 Kg and could generate any style of flow waveform, was developed. 2) A microcirculation probe that could be implanted into the body and observe continuously the microcirculation in the peripheral system without a microscope was developed. 3) These systems were implanted into goats chronically. The longest implantation period was half yeart and the difference between pulsatile and continuous flow on the living body including microcirculation was analysed during this period.

Research Products

• [Journal Article] Computational fluid dynamics analysis of the pump parameters in the helical flow pump (2014)
  • Author(s): Hosoda K, Ishii K, Isoyama T, Saito I, Inoue Y, Ariyoshi K, Ono T, Nakagawa H, Imachi K, Kumagai H, Abe Y
  • Journal Title: J Artif Organs Volume: 17 Pages: 9-15
  • DOI: 10.1007/s10047-013-0739-8
  • Peer Reviewed
• [Journal Article] The helical flow total artificial heart : implantation in goats (2013)
  • Author(s): Abe Y, Ishii K, Isoyama T, Saito I, Inoue Y, Sato M, Hara S, Hosoda K, Ariyoshi K, Nakagawa H, Ono T, Fukazawa K, Ishihara K, Imachi K
  • Journal Title: Proc 35th Ann Intern Conf IEEE EMBS Pages: 2720-3
  • Peer Reviewed
• [Journal Article] Emergency Life Support System aiming preprimed oxygenator (2013)
  • Author(s): Isoyama T, Ariyoshi K, Nii K, Saito I, Fukunaga K, Inoue Y, Ono T, Ishii K, Hara S, Imachi K, Takai M, Abe Y
  • Journal Title: Proc 35th Ann Intern Conf IEEE EMBS Pages: 5731-4
  • Peer Reviewed
• [Journal Article] Pulsatile Driving of the Helical Flow Pump (2013)
  • Author(s): Ishii K, Hosoda K, Isoyama T, Saito I, Ariyoshi K, Inoue Y, Sato M, Hara S, lee X, Wu S, Ono T, Nakagawa H, Imachi K, Abe Y
  • Journal Title: Proc 35th Ann Intern Conf IEEE EMBS Pages: 2724-7
  • Peer Reviewed
• [Journal Article] Relation between Left Atrial Pressure and the Corresponding Pulse Pressure in the Helical Flow Total Artificial Heart (2013)
  • Author(s): Wu S-Y, Saito I, Isoyama T, Inoue Y, Ishii K, Sato M, Hara S, Hosoda K, Ariyoshi K, Li X, Nakagawa H, Ono T, Abe Y
  • Journal Title: Proc 35th Ann Intern Conf IEEE EMBS Pages: 671-4
  • Peer Reviewed
• [Journal Article] A New Control Method Depending on Primary Phase Angle of Transcutaneous Energy Transmission System for Artificial heart (2013)
  • Author(s): H. Miura, I. Saito, F. Sato, Y. Shiraishi, T. Yambe, and H. Matsuki
  • Journal Title: Proc 35th Ann Intern Conf IEEE EMBS Pages: 5723-6
  • Peer Reviewed
• [Journal Article] Characteristics of magnetic probes for identifying sentinel lymph nodes (2013)
  • Author(s): Tetsu Ookubo, Yusuke Inoue, Dongmin Kim, Hiroyuki Ohsaki, Yusuke Mashiko, Moriaki Kusakabe, and Masaki Sekino
  • Journal Title: Proc 35th Ann Intern Conf IEEE EMBS Pages: 5485-8
  • Peer Reviewed
• [Journal Article] Development of Normal-Suction Boundary Control Method Based on Inflow Cannula Pressure Waveform for the Undulation Pump Ventricular Assist Device (2012)
  • Author(s): Kohei Ishii, Itsuro Saito, Takashi Isoyama, Hidemoto Nakagawa, Nakano Emiko, Toshiya Ono, Wei Shi, Yusuke Inoue, and Yusuke Abe
  • Journal Title: Artificial Organs Volume: 36(9) Pages: 812-816
  • DOI: 10.1111/j.1525-1594.2012.01451.x
  • Peer Reviewed
• [Journal Article] The helical flow pump with a hydrodynamic levitation impeller (2012)
  • Author(s): Abe Y, Ishii K, Isoyama T, Saito I, Inoue Y, Ono T, Nakagawa H, Nakano E, Fukazawa K, Ishihara K, Fukunaga K, Ono M, Imachi K
  • Journal Title: J Artif Organs Volume: 15 Pages: 331-340
  • DOI: 10.1007/s10047-012-0659-z
  • Peer Reviewed
• [Journal Article] Real-time in-home patient monitoring systems using high-speed mobile Internet and remote access (2012)
  • Author(s): T. Isoyama, H. Yamada, I. Saito, M. Sato, Y. Okada, K. Miyahara, H. Ohta, and Y. Abe
  • Journal Title: Proceeding of International Conference on uHealthcare 2012 Pages: 25-26
• [Journal Article] Development of an Implantable Small Observation Camera with Scaffold Chamber for Angiogenesis (2012)
  • Author(s): Yusuke Inoue, Itsuro Saito, Takashi Isoyama, Hidemoto Nakagawa, Toshiya Ono, Kohei Ishii, Koki Ariyoshi, Emiko Nakano, Kou Imachi, Yusuke Abe
  • Journal Title: World Congress 2012 Medical Physics and Biomedical Engineering Proceedings Volume: 39 Pages: 1961-1964
• [Journal Article] Automatic calibration of the inlet pressure sensor for the implantable continuous-flow ventricular assist device (2011)
  • Author(s): Wei Shi, Itsuro Saito, Takashi Isoyama, Hidemoto Nakagawa, Yusuke Inoue, Toshiya Ono, Akimasa Kouno, Kou Imachi, Yusuke Abe
  • Journal Title: Journal of Artificial Organs Volume: 14 Pages: 81-88
  • DOI: 10.1007/s10047-011-0556-x
  • Peer Reviewed
• [Journal Article] Results of animal experiments with the fourth model of the undulation pump total artificial heart in goat (2011)
  • Author(s): Abe Y, Isoyama T, Saito I, Shi W, Inoue Y, Ishii K, Nakagawa H, Ono T, Ono M, Imachi K
  • Journal Title: Artificial Organs Volume: 35(8) Pages: 781-790
  • DOI: 10.1111/j.1525-1594.2011.01318.x
  • Peer Reviewed
• [Journal Article] Preliminary study of physiological control for the undulation pump ventricular assist device (2010)
  • Author(s): Saito I, Ishii K, Isoyama T, Ono T, Nakagawa H, Shi W, Inoue Y, Abe Y
  • Journal Title: Conf Proc IEEE Eng Med Biol Soc Volume: 2010 Pages: 5218-21
  • Peer Reviewed
• [Journal Article] Use of In Vivo Insert Molding to Form a Jellyfish Valve Leaflet (2010)
  • Author(s): Kishi A, Isoyama T, Saito I, Miura H, Nakagawa H, Kouno A, Ono T, Inoue Y, Yamaguchi S, Wei S, Abe Y, Imachi K, and Noshiro M
  • Journal Title: Artificial Organs Volume: 34(12) Pages: 1125-1131
  • Peer Reviewed
• [Presentation] Total artificial heart : what we need? (2013)
  • Author(s): Yusuke Abe
  • Organizer: JSAO & IFAO Joint Congress 2013
  • Place of Presentation: Pacifico Yokohama, Yokohama, Japan
  • Year and Date: 2013-09-29
• [Presentation] Development of a physiological control method for the helical flow total artificial heart (2013)
  • Author(s): Itsuro Saito, Takashi Isoyama, Yusuke Inoue, Masami Sato, Shintaro Hara, Li Xin Yang, Terumi Yurimoto, Haruka Murakami, Wu Sheng Yuan, Yukino Kawase, Yusuke Abe
  • Organizer: JSAO & IFAO Joint Congress 2013
  • Place of Presentation: Pacifico Yokohama, Yokohama, Japan
  • Year and Date: 2013-09-28
• [Presentation] Flow rate and pressure head estimation in helical flow pump using the table method (2013)
  • Author(s): Shintaro Hara, Itsuro Saito, Xinyang Li, Takashi Isoyama, Yusuke Inoue, Kohei Ishii, Masami Sato, Sheng Yuan Wu, Koki Ariyoshi, Yukino Kawase, Yoshinori Kusakabe, Terumi Yurimoto, Haruka Murakami and Yusuke Abe
  • Organizer: JSAO & IFAO Joint Congress 2013
  • Place of Presentation: Pacifico Yokohama, Yokohama, Japan
  • Year and Date: 2013-09-28
• [Presentation] The nonlinearity of left atrium volume-pressure relationship and the applicability in the pressure sensor calibration of helical flow total artificial heart (HFTAH) (2013)
  • Author(s): Sheng-Yuan Wu, Itsuro Saito, Takashi Isoyama, Yusuke Inoue, Masami Sato, Shintaro Hara, Xinyang Li, Terumi Yurimoto, Haruka Murakami, Yukino Kawase, Yusuke Abe
  • Organizer: JSAO & IFAO Joint Congress 2013
  • Place of Presentation: Pacifico Yokohama, Yokohama, Japan
  • Year and Date: 2013-09-28
• [Presentation] Troidal Convolution blood Pump for ECLS system (2013)
  • Author(s): Takashi Isoyama, Koki Ariyoshi, Itsuro Saito, Kazuyoshi Fukunaga, Kou Imachi, and Yusuke Abe
  • Organizer: ASAIO 2013
  • Place of Presentation: Chicago Hilton, Illinois, USA
  • Year and Date: 2013-06-13
• [Presentation] DEVELOPMENT OF HYBRID INFLOW CANNULA FOR VENTRICULAR ASSIST DEVICES (2012)
  • Author(s): Yusuke Inoue, Emiko Nakano, Itsuro Saito, Takashi Isoyama, Hidemoto Nakagawa, Toshiya Ono, Kohei Ishii, Koki Ariyoshi, Kou Imachi, Yusuke Abe
  • Organizer: 39th Congress of ESAO
  • Place of Presentation: Academy of Music and Theatre, Rostock, Germany
  • Year and Date: 2012-09-28
• [Presentation] Development of Hybrid Inflow Cannula for Helical Flow Ventricular Assist Device (2012)
  • Author(s): Yusuke Inoue, Emiko Nakano, Itsuro Saito, Takashi Isoyama, Hidemoto Nakagawa, Toshiya Ono, Kohei Ishii, Koki Ariyoshi, Kou Imachi, Yusuke Abe
  • Organizer: ISRBP2012 (20th Congress of the International Society for Rotary Blood Pumps)
  • Place of Presentation: Grand Cevahir Hotel, Istanbul, Turkey
  • Year and Date: 2012-09-21
• [Remarks]
  • URL: http://www.bme.gr.jp