2013 Fiscal Year Final Research Report
Biomechanical and biochemical analyses of biological tissues in a microscopic level for unified understanding of mechanical adaptation mechanism of biological tissues
| Project/Area Number |
22240055
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Nagoya Institute of Technology |
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Principal Investigator |
MATSUMOTO Takeo 名古屋工業大学, 工学(系)研究科(研究院), 教授 (30209639)
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| Co-Investigator(Kenkyū-buntansha) |
NAGAYAMA Kazuaki 名古屋工業大学, 大学院・工学研究科, 准教授 (10359763)
SUGITA Shukei 名古屋工業大学, 大学院・工学研究科, 助教 (20532104)
MATSUMOTO Akio 千葉大学, 大学院・医学研究科, 准教授 (60437308)
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| Project Period (FY) |
2010-04-01 – 2014-03-31
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| Keywords | バイオメカニクス / 力学解析 / 細胞・組織 / 循環器・高血圧 / 生物・生体工学 |
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| Research Abstract |
Biological tissues change themselves actively in response to force applied to them. To elucidate this mechanism, we need to know stress and strain distributions at cellular level and compare it with proteins synthesized by each cell. We performed tensile test for thin-sliced specimens of thoracic aortas under a microscope to observe microscopic deformation of cells and tissues during macroscopic stretch, and found that tension applied in the in vivo state is lower in the elastic lamina with large waviness under no load condition. We also performed RNA microarray analysis to find genes whose expression is different between the ventral and dorsal side of the thoracic aorta, and identified several proteins that have significant correlations with the waviness of the elastic lamina.
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