2012 Fiscal Year Final Research Report
Elucidation of Biological Adaptation and Remodeling Mechanisms to Mechanical Stress Based on the Development of Novel Micro-Electro-Mechanical Systems (MEMS) technology
| Project/Area Number |
22240056
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Okayama University |
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Principal Investigator |
NARUSE Keiji 岡山大学, 大学院・医歯薬学総合研究科, 教授 (40252233)
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| Co-Investigator(Kenkyū-buntansha) |
MOHRI Satoshi 川崎医科大学, 医学部, 教授 (00294413)
NAKAMURA Kazufumi 岡山大学, 岡山大学病院, 講師 (10335630)
TAKEI Kohji 岡山大学, 大学院・医歯薬学総合研究科, 教授 (40322226)
YAMADA Hiroshi 岡山大学, 大学院・医歯薬学総合研究科, 准教授 (80325092)
IRIBE Gentaro 岡山大学, 大学院・医歯薬学総合研究科, 助教 (90284885)
KATANOSAKA Yuki 岡山大学, 大学院・医歯薬学総合研究科, 助教 (60432639)
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| Project Period (FY) |
2010 – 2012
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| Keywords | メカノセンサー / 機械受容システム / メカノトランスダクション |
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| Research Abstract |
Physical and mechanical stimuli such as gravity, extension, and shearing stress are generated throughout a living body. It has been gradually revealed that these stimuli, which are transmitted via the mechanotransduction mechanisms of cells, are not simply detrimental stresses for living organisms, but rather are biological information essential to developmental processes and functional adaptation of organs. In this project, on the basis of the development of original loading systems for mechanical stress to cells and tissues, the cellular adaptive responses to the mechanical stimuli and their transduction mechanisms in a variety of mechanosensitive tissues are to be examined. Thus, the project aims toelucidate the molecular mechanisms and roles of mechanotransduction system, which is utilized as a basis of many physiological events. It can also contribute to develop therapeutic approach to cancer invasion, cardiac hypertrophy, and regeneration of neuronal circuit.
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[Journal Article] Mechanical stretch increases the proliferation while inhibiting the osteogenic differentiation in dental pulp stem cells2013
Author(s)
Hata M, Naruse K, Ozawa S, Kobayashi Y, Nakamura N, Kojima N, Omi M, Katanosaka Y, Nishikawa T, Naruse K, Tanaka Y, Matsubara T
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Journal Title
Tissue. Eng. Part. A
Volume: 19
Pages: 625-633
Peer Reviewed
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[Journal Article] Archipelago architecture of the focal adhesion: membrane molecules freely enter and exit from the focal adhesion zone2012
Author(s)
Shibata AC, Fujiwara TK, Chen L, Suzuki KG, Ishikawa Y, Nemoto YL, Miwa Y, Kalay Z, Chadda R, Naruse K, Kusumi A
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Journal Title
Cytoskeleton
Volume: 69
Pages: 380-392
Peer Reviewed
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[Remarks] (1)22年6月21日日本産業新聞「卵細胞培養し不妊治療」
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[Remarks] (2)22年8月22日山陽新聞「良質受精卵高率で培養」
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[Remarks] (3)23年8月31日NHK「ためしてガッテン:もみ出し&マッサージホントの実力大検証!」
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[Remarks] (4)23年12月5日日本経済新聞「細胞培養技術」
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[Remarks] (5)24年1月25日NHK「ためしてガッテン:30秒で肌が!血管が!冬の若返りストレッチ」
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