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2012 Fiscal Year Final Research Report

Elucidation of Biological Adaptation and Remodeling Mechanisms to Mechanical Stress Based on the Development of Novel Micro-Electro-Mechanical Systems (MEMS) technology

Research Project

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Project/Area Number 22240056
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Biomedical engineering/Biological material science
Research InstitutionOkayama University

Principal Investigator

NARUSE Keiji  岡山大学, 大学院・医歯薬学総合研究科, 教授 (40252233)

Co-Investigator(Kenkyū-buntansha) MOHRI Satoshi  川崎医科大学, 医学部, 教授 (00294413)
NAKAMURA Kazufumi  岡山大学, 岡山大学病院, 講師 (10335630)
TAKEI Kohji  岡山大学, 大学院・医歯薬学総合研究科, 教授 (40322226)
YAMADA Hiroshi  岡山大学, 大学院・医歯薬学総合研究科, 准教授 (80325092)
IRIBE Gentaro  岡山大学, 大学院・医歯薬学総合研究科, 助教 (90284885)
KATANOSAKA Yuki  岡山大学, 大学院・医歯薬学総合研究科, 助教 (60432639)
Project Period (FY) 2010 – 2012
Keywordsメカノセンサー / 機械受容システム / メカノトランスダクション
Research Abstract

Physical and mechanical stimuli such as gravity, extension, and shearing stress are generated throughout a living body. It has been gradually revealed that these stimuli, which are transmitted via the mechanotransduction mechanisms of cells, are not simply detrimental stresses for living organisms, but rather are biological information essential to developmental processes and functional adaptation of organs. In this project, on the basis of the development of original loading systems for mechanical stress to cells and tissues, the cellular adaptive responses to the mechanical stimuli and their transduction mechanisms in a variety of mechanosensitive tissues are to be examined. Thus, the project aims toelucidate the molecular mechanisms and roles of mechanotransduction system, which is utilized as a basis of many physiological events. It can also contribute to develop therapeutic approach to cancer invasion, cardiac hypertrophy, and regeneration of neuronal circuit.

  • Research Products

    (37 results)

All 2013 2012 2011 2010 Other

All Journal Article (19 results) (of which Peer Reviewed: 19 results) Presentation (3 results) Book (3 results) Remarks (6 results) Patent(Industrial Property Rights) (6 results)

  • [Journal Article] Mechanical stretch increases the proliferation while inhibiting the osteogenic differentiation in dental pulp stem cells2013

    • Author(s)
      Hata M, Naruse K, Ozawa S, Kobayashi Y, Nakamura N, Kojima N, Omi M, Katanosaka Y, Nishikawa T, Naruse K, Tanaka Y, Matsubara T
    • Journal Title

      Tissue. Eng. Part. A

      Volume: 19 Pages: 625-633

    • Peer Reviewed
  • [Journal Article] Rac1 recruitment to the archipelago structure of the focal adhesion through the fluid membrane as revealed by single-molecule analysis2013

    • Author(s)
      Shibata AC, Chen LH, Nagai R, Ishidate F, Chadda R, Miwa Y, Naruse K, Shirai YM, Fujiwara TK, Kusumi A
    • Journal Title

      Cytoskeleton.

      Volume: 70 Pages: 161-177

    • Peer Reviewed
  • [Journal Article] A tilting embryo culture system increases the number of high-grade human blastocysts with high implantation competence2013

    • Author(s)
      Hara T, Matsuura K, Kodama T, Sato K, Kikkawa Y, Muneto T, Tanaka J, Naruse K.
    • Journal Title

      Reprod. Biomed. Online

      Volume: 26 Pages: 260-8

    • Peer Reviewed
  • [Journal Article] Detection of Micrococcus luteus biofilm formation in microfluidic environments by pH measurement using an ion-sensitive field-effect transistor.2013

    • Author(s)
      Matsuura K, Asano Y, Yamada A, Naruse K.Sensors (Basel)
    • Journal Title

      Sensors.

      Volume: 13 Pages: 2484-2493

    • Peer Reviewed
  • [Journal Article] Mechanobiology in cardiac physiology and diseases2013

    • Author(s)
      Takahashi K, Kakimoto Y, Toda K, Naruse K
    • Journal Title

      J. Cell. Mol. Med

      Volume: 17 Pages: 225-232

    • Peer Reviewed
  • [Journal Article] Ex vivo real-time observation of Ca^2+ signaling in living bone in response to shear stress applied on the bone surface2013

    • Author(s)
      Ishihara Y, Sugawara Y, Kamioka H, Kawanabe N, Hayano S, Balam TA, Naruse K, Yamashiro T
    • Journal Title

      Bone.

      Volume: 53 Pages: 204-215

    • Peer Reviewed
  • [Journal Article] Archipelago architecture of the focal adhesion: membrane molecules freely enter and exit from the focal adhesion zone2012

    • Author(s)
      Shibata AC, Fujiwara TK, Chen L, Suzuki KG, Ishikawa Y, Nemoto YL, Miwa Y, Kalay Z, Chadda R, Naruse K, Kusumi A
    • Journal Title

      Cytoskeleton

      Volume: 69 Pages: 380-392

    • Peer Reviewed
  • [Journal Article] In situ imaging of the autonomous intracellular Ca^2+ oscillations of osteoblasts and osteocytes in bone2012

    • Author(s)
      Ishihara Y, Sugawara Y, Kamioka H, Kawanabe N, Kurosaka H, Naruse K, Yamashiro T
    • Journal Title

      Bone

      Volume: 50 Pages: 842-852

    • Peer Reviewed
  • [Journal Article] Screening of sperm velocity by fluid mechanical characteristics of a cyclo-olefin polymer microfluidic sperm-sorting device2012

    • Author(s)
      Matsuura K, Takenami M, Kuroda Y, Hyakutake T, Yanase S, Naruse K
    • Journal Title

      Reprod. Biomed. Online.

      Volume: 24 Pages: 109-115

    • Peer Reviewed
  • [Journal Article] The mechanical stimulation of cells in 3D culture within a self-assembling peptide hydrogel2012

    • Author(s)
      Nagai Y, Yokoi H, Kaihara K, Naruse K.
    • Journal Title

      Biomaterials

      Volume: 33 Pages: 1044-51

    • Peer Reviewed
  • [Journal Article] Microtubule dynamics regulate cyclic stretch-induced cell alignment in human airway smooth muscle cells.2011

    • Author(s)
      Morioka M, Parameswaran H, Naruse K,Kondo M, Sokabe M, Hasegawa Y, Suki B, Ito S
    • Journal Title

      PLoS One

      Volume: 6 Pages: e26384

    • DOI

      doi:10.1371/journal.pone.0026384

    • Peer Reviewed
  • [Journal Article] Role of sarcolemmal BK(Ca) channels in stretch-induced extrasystoles in isolated chick hearts2011

    • Author(s)
      Iribe G, Jin H, Naruse K
    • Journal Title

      Circ. J

      Volume: 75 Pages: 2552-8

    • Peer Reviewed
  • [Journal Article] Comparison between loose fragment chondrocytes and condyle fibrochondrocytes in cellular proliferation and redifferentiation.2011

    • Author(s)
      Takata N, Furumatsu T, Abe N, Naruse K, Ozaki T
    • Journal Title

      J. Orthop. Sci.

      Volume: 16 Pages: 589-597

    • Peer Reviewed
  • [Journal Article] Ischemia-induced angiogenesis is impaired in aminopeptidase A deficient mice via down-regulation of HIF-1α.2010

    • Author(s)
      Kubota R, Numaguchi Y, Ishii M, Niwa M, Okumura K, Naruse K, Murohara T
    • Journal Title

      Biochem. Biophys. Res. Commun

      Volume: 402 Pages: 396-401

    • Peer Reviewed
  • [Journal Article] In-vitro culture with a tilting device in chemically defined media during meiotic maturation and early development improves the quality of blastocysts derived from in-vitro matured and fertilized porcine oocytes2010

    • Author(s)
      Koike T, Matsuura K, Naruse K, Funahashi H
    • Journal Title

      J. Reprod.Dev.

      Volume: 56 Pages: 552-557

    • Peer Reviewed
  • [Journal Article] Application of a microfluidic sperm sorter to the in-vitro fertilization of porcine oocytes reduced the incidence of polyspermic penetration2010

    • Author(s)
      Sano H, Matsuura K, Naruse K, Funahashi H
    • Journal Title

      Theriogenology.

      Volume: 74 Pages: 863-870

    • Peer Reviewed
  • [Journal Article] Effects of axial stretch on sarcolemmal BKCa channels in post-hatch chick ventricular myocytes2010

    • Author(s)
      ribe G, Jin H, Kaihara K, Naruse K
    • Journal Title

      Exp. Physiol.

      Volume: 95 Pages: 699-711

    • Peer Reviewed
  • [Journal Article] Blastocyst quality scoring based on morphologic grading correlates with cell number2010

    • Author(s)
      Matsuura K, Hayashi N, Takiue C, Hirata R, Habara T, Naruse K
    • Journal Title

      Fertil. Steril

      Volume: 94 Pages: 1135-1137

    • Peer Reviewed
  • [Journal Article] Actin cytoskeleton regulates stretch-activated Ca^2+ influx in human pulmonary microvascular endothelial cells2010

    • Author(s)
      Ito S, Suki B, Kume H, Numaguchi Y, Ishii M, Iwaki M, Kondo M, Naruse K, Hasegawa Y, Sokabe M
    • Journal Title

      Am. J. Respir. Cell. Mol. Biol

      Volume: 43 Pages: 26-34

    • Peer Reviewed
  • [Presentation] Conformational change of membrane proteins in response to membrane tension -a coarse grained molecular dynamics simulation study.2012

    • Author(s)
      Takahashi K, Toda K, Saruwatari K, Yokoyama T, Naruse K, Sokabe M
    • Organizer
      BIT's 5th Annual Protein and Peptide Conference
    • Place of Presentation
      China
    • Year and Date
      20120323-25
  • [Presentation] Automatic measurement system for biological applications based on pH using ISFET sensor probe.2010

    • Author(s)
      Yamada A, Mohri S, Nakamura M, Naruse K
    • Organizer
      MHS2010&Micro-Nano Global COE
    • Place of Presentation
      Nagoya
    • Year and Date
      20101107-10
  • [Presentation] Application of Mechanical Stimuli using a Microfluidic Air Actuating System to Cultured Mammalian Embryos2010

    • Author(s)
      Li JC, Matsuura K, Kuroda Y, Funahashi H, Naruse K
    • Organizer
      MHS2010&Micro-Nano Global COE
    • Place of Presentation
      Nagoya
    • Year and Date
      20101107-10
  • [Book] Use of Silicone Elastomer-Based Microfluidic Devices and Systems in Reproductive Technologies. Advanced Elastomers - Technology2012

    • Author(s)
      Matsuura K, Naruse K
    • Total Pages
      243-262
    • Publisher
      Properties and Applications
  • [Book] Stretch-activated BK channel and heart function. Prog. Biophys. Mol. Biol.2012

    • Author(s)
      Takahashi K, Naruse K.
    • Total Pages
      239-244
  • [Book] 第5章アクチュエータが切り拓く医療、福祉:5.1医学、バイオ研究での利用. アクチュエータが未来を造る2011

    • Author(s)
      成瀬恵治
    • Total Pages
      177-186
    • Publisher
      産業図書(株)出版
  • [Remarks] (1)22年6月21日日本産業新聞「卵細胞培養し不妊治療」

  • [Remarks] (2)22年8月22日山陽新聞「良質受精卵高率で培養」

  • [Remarks] (3)23年8月31日NHK「ためしてガッテン:もみ出し&マッサージホントの実力大検証!」

  • [Remarks] (4)23年12月5日日本経済新聞「細胞培養技術」

  • [Remarks] (5)24年1月25日NHK「ためしてガッテン:30秒で肌が!血管が!冬の若返りストレッチ」

  • [Remarks] ホームページ

    • URL

      http://www.okayama-u.ac.jp/user/med/phy2/

  • [Patent(Industrial Property Rights)] 平面パッチクランプ用支持体の製造方法2012

    • Inventor(s)
      成瀬恵治
    • Industrial Property Rights Holder
      国立大学法人岡山大学
    • Industrial Property Number
      特許第4899051 号
    • Acquisition Date
      2012-01-13
  • [Patent(Industrial Property Rights)] 卵細胞の培養装置2012

    • Inventor(s)
      成瀬恵治、舟橋弘晃、石田敬雄、松浦宏治、原 鐵晃
    • Industrial Property Rights Holder
      国立大学法人岡山大学
    • Industrial Property Number
      特許第5083952 号
    • Acquisition Date
      2012-09-14
  • [Patent(Industrial Property Rights)] 細胞培養器2011

    • Inventor(s)
      永井祐介、成瀬恵治
    • Industrial Property Rights Holder
      国立大学法人岡山大学、(株)メニコン
    • Industrial Property Number
      特願 2011-099776, PCT/JP2012/061271
    • Filing Date
      2011-04-26
  • [Patent(Industrial Property Rights)] 機械受容(StretchActivated)チャネルの活性化抑制剤2011

    • Inventor(s)
      成瀬恵治、曽我部正博
    • Industrial Property Rights Holder
      名古屋大学
    • Industrial Property Number
      特許第4654432 号
    • Acquisition Date
      2011-01-07
  • [Patent(Industrial Property Rights)] 高強度ペプチドゲル (クロスリンク法による高強度ペプチドハイドロゲル)2010

    • Inventor(s)
      松浦 宏治、北松 瑞生、黒田 ユカ、永井 祐介、成瀬 恵治
    • Industrial Property Rights Holder
      国立大学法人岡山大学、(株)メニコン
    • Industrial Property Number
      特願 2010-287249
    • Filing Date
      2010-12-24
  • [Patent(Industrial Property Rights)] 自己組織化ペプチドおよび高強度ペプチドゲル2010

    • Inventor(s)
      永井祐介、横井秀典、上杉晃司、成瀬恵治
    • Industrial Property Rights Holder
      国立大学法人岡山大学、(株)メニコン
    • Industrial Property Number
      特許第4620804 号
    • Acquisition Date
      2010-11-05

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Published: 2014-08-29  

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