2013 Fiscal Year Final Research Report
Development of dynamic culture technology using tissue elements for 3-dimensional tissue regeneration
| Project/Area Number |
22240058
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
USHIDA Takashi 東京大学, 医学(系)研究科(研究院), 教授 (50323522)
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| Co-Investigator(Kenkyū-buntansha) |
FURUKAWA Katsuko 東京大学, 大学院・工学系研究科, 准教授 (90343144)
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| Project Period (FY) |
2010-04-01 – 2014-03-31
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| Keywords | 細胞・組織工学 / 動的培養技術 |
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| Research Abstract |
We developed the dynamic tissue culture system enabling 3-dimensional tissue regeneration of articular cartilages, and the non-invasive method for evaluating the degrees of their regeneration. We adopted the stress-strain controlled dynamic compression system and the terahertz time-domain spectroscopy for that purpose. The results showed that the production of the matrices such as collagen type I and sGAG significantly increased under the dynamic culture conditions. We found also the correlation between complex dielectric constants and the degree of tissue regeneration in cartilages according to the data obtained by terahertz time-domain spectroscopy, showing the feasibility of non-invasive evaluation of regenerated cartilages.
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[Journal Article] Feasibility and limitations of round robin test for assessment of evaluation protocols in tissue-engineered medical product2012
Author(s)
Masako Yokoi, Koji Hattori, Koichi Narikawa, Hajime Ohgushi, Mika Tadokoro, Kazuto Hoshi, Tsuyoshi Takato, Akira Myoui, Katsuhiko Nanno, Yukio Kato, Masami Kanawa, Katsura Sugawara, Tomoko Kobo and Takashi Ushida
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Journal Title
Journal of Tissue Engineering and Regenerative Medicine
Volume: 6
Pages: 550-558
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