Generic biofunctionalization of metals with electrodeposition of functional and biomolecules

2014 Fiscal Year Final Research Report

• Project/Area Number: 22240059
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Biomedical engineering/Biological material science
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: TAKAO Hanawa 東京医科歯科大学, 生体材料工学研究所, 教授 (90142736)
• Co-Investigator(Kenkyū-buntansha): DOI Hisashi 東京医科歯科大学, 生体材料工学研究所, 助教 (30251549) ; ASHIDA Maki 東京医科歯科大学, 生体材料工学研究所, 助教 (50708386) ; TSUTSUMI Yusuke 東京医科歯科大学, 生体材料工学研究所, 助教 (60447498) ; 陳 鵬 東京医科歯科大学, 生体材料工学研究所, 特任助教 (70708388)
• Project Period (FY): 2010-04-01 – 2015-03-31
• Keywords: 生体材料 / インプラント / 表面改質 / 生体機能 / 機能分子 / 電着 / 固定化

Outline of Final Research Achievements

The mechanism of the inhibition of bacterial adhesion and biofilm formation on titanium with electrodeposition of PEG was elucidated. RGD-immobilized through electrodeposited PEG on titanium is effective to improve the hard tissue compatibility of titanium when the material was implanted into rat tibia. Moreover, the ccurrent density was large when concetration of NH2-PEG-NH2 in electrolite. This indicated thatNH2-PEG-NH2 electricallly disociated and undisociated repeatedly near titanium surface during electrodeposition and fibnally the amino terminals bond to titanium surface, generating the immbolization with U-shape. On the other hand, MPC polymer is also electrodeposited to titanium surafce by electrodeposition and the surafce inhibited eh adhesion of fibrin network formation.

Free Research Field

生体材料学