Pysical Inactivities and systemic inflammation. Investigation of anti-inflammatory effects of exercise in patiens with chronic respiratory disease

2014 Fiscal Year Final Research Report

• Project/Area Number: 22240066
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: Tohoku University
• Principal Investigator: KUROSAWA Hajime 東北大学, 環境・安全推進センター, 教授 (60333788)
• Co-Investigator(Kenkyū-buntansha): NAGASE Takahide 東京大学, 大学病院, 教授 (40208004)
• Co-Investigator(Renkei-kenkyūsha): OGAWA Hiromasa 東北大学, 環境・安全推進センター, 准教授 (90361162) ; KOHZUKI Masahiro 東北大学, 大学院医学系研究科, 教授 (70234698) ; IROKAWA Toshiya 東北大学, 環境・安全推進センター, 准教授 (70375179)
• Project Period (FY): 2010-04-01 – 2015-03-31
• Keywords: ミオカイン / 身体活動性 / IL-6 / ミオスタチン / 慢性閉塞性肺疾患 / 骨格筋 / 収縮

Outline of Final Research Achievements

Recently, importance of physical activity in patients with chronic respiratory disease is being generally recognized. A group of cytokines, called "myokines", which is secreted from skeletal muscles is supposed to be one of the mechanisms of the effects. Myokines are stored in vesicles of muscle cells as like cocktails, and selected the selected molecules out of the cocktails under the certain stimullation or stress. In human exercise tests, blood IL-6, one of main myokines, was increased during and after the exercise, whereas blood myostatin seemed to be biphasic. The trigger of the secretion is mainly considered to be the muscle constriction. However, other mechanisms are possively invloved as the triggers. Baseline IL-6 blood level, contrally to myostatin, is lower in physically active subjects than in not active.

Free Research Field

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