2012 Fiscal Year Final Research Report
Evaluation of the Effects of Rehabilitation Based on SerumProteome and Free Amino Acid Levels
| Project/Area Number |
22240067
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (A)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Rehabilitation science/Welfare engineering
|
|---|
| Research Institution | Fujita Health University |
|---|
Principal Investigator |
BEPPU Hidehiro (BEPPU Hidehiko) 藤田保健衛生大学, 藤田記念七栗研究所, 准教授 (30142582)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
HAYASHI Nobuhiro 東京工業大学, 生命理工学研究科, 准教授 (80267955)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
SONODA Sigeru 藤田保健衛生大学, 医学部, 教授 (10197022)
MIZUTANI Kenmei 藤田保健衛生大学, 藤田記念七栗研究所, 助教 (30351068)
YAMAGUCHI Kumiko 藤田保健衛生大学, 藤田記念七栗研究所, 技術員 (50526308)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Keywords | リハビリ訓練 / 脳卒中回復期 / 微量成分検索 / サイトカイン / 筋肉成分 |
|---|
| Research Abstract |
With a view to the establishment of an index marker applicable to patients undergoing rehabilitation, based on biogenic factors, this study aimed to develop a method to evaluate the effects of such approaches, based on serum free amino acid levels. Serum collected from post-acute rehabilitation ward patients was analyzed using UPLC-MS. On single regression analysis of rehabilitation items and changes in amino acid levels, a positive correlation was observed between the lengths of time from the onset to discharge and hospital stay and L-arginine levels, and between FIM gain and L-serine and L-arginine levels, suggesting that changes in serum free amino acidlevels during rehabilitation may depend on the levels of exercise and daily activities.
|
Research Products
(27 results)
-
-
-
-
-
-
[Presentation] Development of human serum proteomics.2012
Author(s)
Ken Hirosaki, Hidehiko Beppu, Lumi Negishi, Paxton Thanai, Takayuki Yonezawa, Shigeru Sonoda, Ung-il Chung, Nobuhiro Hayashi
Organizer
The 85th Annual Meeting of the Japanese Biochemical Society
Place of Presentation
Fukuoka, Japan
Year and Date
20121214-16
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
