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2012 Fiscal Year Final Research Report

Mechanism and regulation of gastric carcinogenesis directed by the Helicobacter pylori CagA oncoprotein

Research Project

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Project/Area Number 22240085
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Carcinogenesis
Research InstitutionThe University of Tokyo

Principal Investigator

HATAKEYAMA Masanori  東京大学, 大学院・医学系研究科, 教授 (40189551)

Project Period (FY) 2010 – 2012
Keywords癌 / 感染症 / 細菌 / シグナル伝達
Research Abstract

Helicobacter pylori CagA-positive strains play a key role in thedevelopment of gastric carcinoma. This project elucidated 1) the mechanism by which H. pylori delivers its oncoprotein CagA into host gastric epithelial cells: 2) identified Pragmin,a human protein the function of which is mimicked by delivered CagA: and 3) uncoveredmolecular pathway that directs reprograming of gastric epithelial cells into intestinal-likecells upon chronic infection with cagA-positive H. pylori. Finally, the H. pylori CagAprotein was crystalized and its three-dimensional structure was solved by X-ray analysis.

  • Research Products

    (74 results)

All 2013 2012 2011 2010

All Journal Article (18 results) (of which Peer Reviewed: 18 results) Presentation (56 results)

  • [Journal Article] Where do theycome from? What are they? Where are theygoing?2013

    • Author(s)
      Hayashi, T., Morohashi, H. and Hatakeyama,M. Bacterial EPIYA effectors -
    • Journal Title

      Cell. Microbiol.

      Volume: 15 Pages: 377-385

    • Peer Reviewed
  • [Journal Article] PAR1btakes the stage in the morphogenetic andmotogenetic activity of Helicobacter pylori CagAoncoprotein.2013

    • Author(s)
      Yamahashi, Y. and Hatakeyama, M.
    • Journal Title

      Cell Ad.h Migr.

      Volume: 7 Pages: 11-17

    • Peer Reviewed
  • [Journal Article] CDX1 directs gastric intestinalmetaplasia via induction of stemness-associatedreprogramming factors SALL4 and KLF5. Proc.Natl.2012

    • Author(s)
      Fujii, Y., Yoshihashi, K., Tsutsumi, S., Mutoh,H., Suzuki, H., Maeda, S., Aburatani, H. andHatakeyama, M.
    • Journal Title

      Acad. Sci. USA

      Volume: 109 Pages: 20584-20589

    • Peer Reviewed
  • [Journal Article] Reactiveoxygen species-induced autophagic degradationof Helicobacter pylori CagA is specificallysuppressed in cancer stem-like cells.2012

    • Author(s)
      Tsugawa, H., Suzuki, H., Saya, H.,Hatakeyama, M., Hirayama, T., Hirata, K.,Nagano, O., Matsuzaki, J. and Hibi, T.
    • Journal Title

      Cell HostMicrobe

      Volume: 12 Pages: 764-777

    • Peer Reviewed
  • [Journal Article] Tertiary structure-function analysis reveals thepathogenic signaling potentiation mechanism ofHelicobacter pylori oncogenic effector CagA.2012

    • Author(s)
      Hayashi, T., Senda, M., Morohashi, H.,Higashi, H., Horio, M., Nagase, L., Sasaya, D.,Shimizu, T., Venugopalan, N., Kumeta, H., Noda,N. N., Inagaki, F., Senda, T. and Hatakeyama, M.
    • Journal Title

      Cell Host Microbe

      Volume: 12 Pages: 20-33

    • Peer Reviewed
  • [Journal Article] Giraud, A.S. and Menheniott,2012

    • Author(s)
      Lee, K.S., Kalantzis, A., Jackson, C.B.,O'Connor, L., Mutaya-Kamiya, N., Hatakeyama,M., Judd, L.M.
    • Journal Title

      T.R. Plos One

      Volume: 7 Pages: e30786

    • Peer Reviewed
  • [Journal Article] Helicobacter pyloristimulates epithelial cell migration viaCagA-mediated perturbation of host cellsignaling.2012

    • Author(s)
      Kikuchi, K., Murata-Kamiya, N., Kondo, S.and Hatakeyama, M.
    • Journal Title

      Microbes Infect.

      Volume: 14 Pages: 470-476

    • Peer Reviewed
  • [Journal Article] Polarity-regulating kinasepartitioning-defective 1b (PAR1b) phosphorylatesguanine nucleotide exchange factor H1 (GEF-H1)to regulate RhoA-dependent actin cytoskeletalreorganization.2011

    • Author(s)
      Yamahashi, Y., Saito, Y., Murata-Kamiya, N.and Hatakeyama, M.
    • Journal Title

      J. Biol. Chem.

      Volume: 286 Pages: 44576-44584

    • Peer Reviewed
  • [Journal Article] Mammalian Pragmin regulatesSrc family kinases via the Glu-Pro-Ile-Tyr-Ala(EPIYA) motif that is exploited by bacterialeffectors.2011

    • Author(s)
      Safari, F., Murata-Kamiya, N., Saito, Y. andHatakeyama, M.
    • Journal Title

      Proc. Natl. Acad. Sci. USA

      Volume: 108 Pages: 14938-14943

    • Peer Reviewed
  • [Journal Article] Potentiation of Helicobacterpylori CagA protein virulence throughhomodimerization.2011

    • Author(s)
      Nagase, L., Murata-Kamiya, N. andHatakeyama, M.
    • Journal Title

      J. Biol. Chem.

      Volume: 286 Pages: 33622-33631

    • Peer Reviewed
  • [Journal Article] Evolution of cagA oncogene ofHelicobacter pylori through recombination.2011

    • Author(s)
      Furuta, Y., Yahara, K., Hatakeyama, M. andKobayashi, I.
    • Journal Title

      PlosOne

      Volume: 6 Pages: e23499

    • Peer Reviewed
  • [Journal Article] Rozenblatt-Rosen, O., Meyerson, M., Neel, B. G.and Hatakeyama, M. SHP2 tyrosine phosphataseconverts parafibromin/Cdc73 from a tumorsuppressor to an oncogenic driver.2011

    • Author(s)
      Takahashi, A., Tsutsumi, R., Kikuchi, I.,Obuse, C., Saito, Y., Seidi, A., Karisch, R.,Fernandez, M., Cho, T., Ohnishi, N.,
    • Journal Title

      Mol. Cell

      Volume: 43 Pages: 45-56

    • Peer Reviewed
  • [Journal Article] Anthropological and clinicalimplications for the structural diversity of theHelicobacter pylori CagA oncoprotein.2011

    • Author(s)
      Hatakeyama, M.
    • Journal Title

      Cancer Sci.

      Volume: 102 Pages: 36-43

    • Peer Reviewed
  • [Journal Article] Conversion ofHelicobacter pylori CagA from senescenceinducer to oncogenic driver throughpolarity-dependent regulation of p21.2010

    • Author(s)
      Saito, Y., Murata-Kamiya, N., Hirayama, T.,Ohba, Y. and Hatakeyama, M.
    • Journal Title

      J. Exp.Med.

      Volume: 207 Pages: 2157-2174

    • Peer Reviewed
  • [Journal Article] Helicobacterpylori exploits host membrane phosphatidylserinefor delivery, localization and pathophysiologicalaction of the CagA oncoprotein.2010

    • Author(s)
      Murata-Kamiya, N., Kikuchi, K., Hayashi, T,Higashi, H. and Hatakeyama, M.
    • Journal Title

      Cell HostMicrobe

      Volume: 7 Pages: 399-4111

    • Peer Reviewed
  • [Journal Article] Helicobacter pylori infection, oncogenicpathways and epigenetic mechanisms in gastriccarcinogenesis.2010

    • Author(s)
      Ding, S-Z., Goldberg, J. B. and Hatakeyama, M.
    • Journal Title

      Future Oncol.

      Volume: 6 Pages: 851-862

    • Peer Reviewed
  • [Journal Article] The CagA protein of Helicobacterpylori suppresses the functions of DCs in mice.2010

    • Author(s)
      Tanaka, H., Yoshida, M., Nishiumi, S.,Ohnishi, N., Kobayashi, K., Yamamoto, K.,Fujita, T., Kutsumi, H., Hatakeyama, M. andAzuma, T.
    • Journal Title

      Arch. Biochem. Biophys

      Volume: 7 Pages: 35-42

    • Peer Reviewed
  • [Journal Article] Helicobacter pylori-induced histonemodification, associated gene expression ingastric epithelial cells, and its implication inpathogenesis.2010

    • Author(s)
      Ding, S-Z., Fischer, W., Kaparakis-Liaskos,M., Lietchi, G., Merrell, S., Grant, P., Ferrero, R.,Crowe, S., Haas, R., Hatakeyama, M. andGoldberg, J.
    • Journal Title

      Plos One

      Volume: 5 Pages: e9875

    • Peer Reviewed
  • [Presentation] Helicobacter pylori CagA,a bacterial protein acting as an oncogenic scaffold/hub in mammalian cells2013

    • Author(s)
      畠山昌則
    • Organizer
      3rd MaxPlanck Institutes-University of Tokyo/MedJoint Conference.
    • Place of Presentation
      ItoInternational Research Cencer, Universityof Tokyo, Tokyo
    • Year and Date
      2013-03-07
  • [Presentation] Helicobacter pylori CagA,a bacterial oncoprotein that directsgastric carcinogenesis2013

    • Author(s)
      畠山昌則
    • Organizer
      19thInternational Charles Heidelberger Symposium on Cancer Research ?Carcinogenesis and Chemotherapy.
    • Place of Presentation
      William Wills Hall, KagoshimaUniversity, Kagoshima
    • Year and Date
      2013-02-15
  • [Presentation] Mechanisms determiningsubcellular localization of SHP2 tyrosine phosphatase2013

    • Author(s)
      畠山昌則
    • Organizer
      10th InternationalConference on Protein Phosphatase,Special Lecture.
    • Place of Presentation
      International Lecture Hall, Foundationfor Promotion of Cancer Research, Tokyo
    • Year and Date
      2013-02-08
  • [Presentation] ピロリ菌がんタンパク質CagAの3次元構造と機能2013

    • Author(s)
      畠山昌則
    • Organizer
      平成24年度文部科学省新学術領域研究「がん支援」公開シンポジウム
    • Place of Presentation
      学術総合センタ - 、東京
    • Year and Date
      2013-01-29
  • [Presentation] Helicobacter pylori CagA,a bacterial protein acting as anconcogenic scaffold/hub in mammaliancells2013

    • Author(s)
      畠山昌則
    • Organizer
      3rd International Symposium onCarcinogenic Spiral.
    • Place of Presentation
      エクセル東急ホテル、金沢
    • Year and Date
      2013-01-24
  • [Presentation] How does H. pylori causegastric carcinoma?"American Associationfor cancer Research (AACR) Annual Meeting20122012

    • Author(s)
      畠山昌則
    • Organizer
      Meet-the-Expert Sessions
    • Place of Presentation
      McCormick Convention Center, Chicago, USA
    • Year and Date
      20120400
  • [Presentation] Helicobacter pylori CagAact as as an oncogenic scaffold/hubprotein in mammalian cells2012

    • Author(s)
      畠山昌則
    • Organizer
      The 2nd Japanese-French Cancer Workshop
    • Place of Presentation
      Grand XIV Naruto, Tokushima
    • Year and Date
      2012-11-30
  • [Presentation] ピロリ菌がんタンパク質CagAの三次元分子構造2012

    • Author(s)
      畠山昌則
    • Organizer
      京都大学ウイルス研究所セミナー
    • Place of Presentation
      京都大学ウイルス研究所、京都
    • Year and Date
      2012-11-15
  • [Presentation] Role of Helicobacter pylori CagA oncoprotein in gastriccarcinogenesis2012

    • Author(s)
      畠山昌則
    • Organizer
      第71回日本癌学会総会コアシンポジウム
    • Place of Presentation
      さっぽろ文芸館、札幌
    • Year and Date
      2012-09-19
  • [Presentation] ピロリ菌がんタンパク質CagAの三次元分子構造2012

    • Author(s)
      畠山昌則
    • Organizer
      平成24年度北海道大学遺伝子病制御研究所研究集会.感染癌のエフェクター分子とその標的
    • Place of Presentation
      北海道大学医学部フラテ会館、札幌
    • Year and Date
      2012-09-18
  • [Presentation] Three dimensionalstructure of the Helicobacter pylori CagAoncoprotein2012

    • Author(s)
      畠山昌則
    • Organizer
      European Helicobacter Study Group 2012Opening Lecture
    • Place of Presentation
      Ljubljana, Slovenia
    • Year and Date
      2012-09-11
  • [Presentation] ピロリ菌がんタンパク質CagAの発がん活性2012

    • Author(s)
      畠山昌則
    • Organizer
      第4回神戸大学次世代シグナル伝達医学グローバル COE 研究検討会・特別講演.
    • Place of Presentation
      淡路夢舞台国際会議場、兵庫
    • Year and Date
      2012-07-09
  • [Presentation] ピロリ菌と胃がん 細 胞が仕掛けるトロイ戦争2012

    • Author(s)
      畠山昌則
    • Organizer
      第12回東京大学生命科学シンポジウム(BIO UT)
    • Place of Presentation
      東京大学安田講堂、東京
    • Year and Date
      2012-06-30
  • [Presentation] 細菌性がんタンパク質と してのピロリ菌 CagA の作用機構2012

    • Author(s)
      畠山昌則
    • Organizer
      第18回日本ヘリコバクター学会学術集会・特別講演
    • Place of Presentation
      岡山コンベンションセンター、岡山
    • Year and Date
      2012-06-29
  • [Presentation] ピロリ菌による胃がん発症機構2012

    • Author(s)
      畠山昌則
    • Organizer
      金沢大学がん進展制御研究所セミナー
    • Place of Presentation
      金沢大学がん進展制御研究所、金沢
    • Year and Date
      2012-05-17
  • [Presentation] H. pylori-mediated gastriccarcinogenesis; a new paradigm of cancerdevelopment2012

    • Author(s)
      畠山昌則
    • Organizer
      第98回日本消化器病学会総会国際交流フォーラム
    • Place of Presentation
      京王プラザホテル、東京
    • Year and Date
      2012-04-20
  • [Presentation] Cellular targets ofHelicobacter pylori CagA oncoprotein "2012

    • Author(s)
      畠山昌則
    • Organizer
      RCAIC 2nd International Symposium onInfection-associated Cancers.
    • Place of Presentation
      Frate Hall, Graduate School ofMedicine, Hokkaido University, Sapporo,Japan
    • Year and Date
      2012-03-13
  • [Presentation] Role of Helicobacter pyloriCagA in gastric carcinogenesis2011

    • Author(s)
      畠山昌則
    • Organizer
      9thChina-Japan Joint Conference of Cancer.
    • Place of Presentation
      Oriental Riverside Hotel,Shanghai, China
    • Year and Date
      2011-12-22
  • [Presentation] Parafibromin/CDC73 is anuclear SHP2 substrate that connects RAsand Wnt signaling pathway2011

    • Author(s)
      畠山昌則
    • Organizer
      1stJapan-Taiwan Bilateral Conference onProtein Phosphatase.
    • Place of Presentation
      National Instit
    • Year and Date
      2011-12-02
  • [Presentation] Molecular mechanism ofgastric carcinogenesis2011

    • Author(s)
      畠山昌則
    • Organizer
      1st France-JapanCancer Meeting 2011.
    • Place of Presentation
      Montpellier, France
    • Year and Date
      2011-11-24
  • [Presentation] ピロリ菌がんタンパク質CagA が機能模倣するヒトタンパク質の同定2011

    • Author(s)
      畠山昌則
    • Organizer
      第56回日本人類遺伝学会・第11回東アジア人類遺伝学会共同大会シンポジウム.
    • Place of Presentation
      幕張メッセ、千葉
    • Year and Date
      2011-11-11
  • [Presentation] Oncogenic Mechanism of Helicobacter pylori CagA2011

    • Author(s)
      畠山昌則
    • Organizer
      The 21stHiroshima Cancer Seminar (HCS)/The 5thThree Universities? ConsortiumInternational Symposium "Recent Progressin Carcinogenesis, Progression andManagement of Upper GI Cancers.
    • Place of Presentation
      International Conference CenterHiroshima, Hiroshima
    • Year and Date
      2011-11-05
  • [Presentation] The Role of Helicobacterpylori oncoprotein CagA in gastriccarcinogenesis2011

    • Author(s)
      畠山昌則
    • Organizer
      Berlin Life ScienceColloquium 2011.
    • Place of Presentation
      PaulErlich Lecture Hall, Max Planck Institutefur Infektionsbiologie, Berlin , Germany)
    • Year and Date
      2011-10-20
  • [Presentation] Infection, Inflammationand Cancer2011

    • Author(s)
      畠山昌則
    • Organizer
      第70回日本癌学会総会モーニングレクチャー
    • Place of Presentation
      名古屋国際会議場、名古屋
    • Year and Date
      2011-10-05
  • [Presentation] Role of H. pylori in gastriccarcinogenesis2011

    • Author(s)
      畠山昌則
    • Organizer
      European HelicobacterStudy Group 2011 International Workshop:Symposium.
    • Place of Presentation
      Dublin, Ireland
    • Year and Date
      2011-09-11
  • [Presentation] ピロリ菌感染による胃がん発症機構2011

    • Author(s)
      畠山昌則
    • Organizer
      第49回大分感染症研究会
    • Place of Presentation
      大分東洋ホテル、大分
    • Year and Date
      2011-09-01
  • [Presentation] Searching for the origin of H. pylori CagA in mammalian proteome CHRO20112011

    • Author(s)
      畠山昌則
    • Organizer
      Concurrent session A: Helicobacter pathogenesis.
    • Place of Presentation
      Vancouver,Canada
    • Year and Date
      2011-08-29
  • [Presentation] 感染発癌の分子機構2011

    • Author(s)
      畠山昌則
    • Organizer
      第50回日本婦人科腫瘍学会学術集会 特別講演
    • Place of Presentation
      札幌コンベンションセンター、札幌
    • Year and Date
      2011-07-23
  • [Presentation] 胃がん原因菌としてのピ ロリ菌の最新知見2011

    • Author(s)
      畠山昌則
    • Organizer
      第238回ヘルスケア研究会
    • Place of Presentation
      日比谷星陵会館、東京
    • Year and Date
      2011-07-13
  • [Presentation] ピロリ菌と胃がん2011

    • Author(s)
      畠山昌則
    • Organizer
      第17回日本癌学会市民公開講座
    • Place of Presentation
      新潟市民プラザ、新潟
    • Year and Date
      2011-06-04
  • [Presentation] In search for the origin ofbacterial EPOIYA effectors in mammals2011

    • Author(s)
      畠山昌則
    • Organizer
      1st Joint Symposium of the Max-Planck Society and University of Tokyo.
    • Place of Presentation
      Parkhotel Schlangenbad, Germany
    • Year and Date
      2011-05-18
  • [Presentation] ヘリコバクター ・ ピロリ癌タンパク質CagAの作用機構2011

    • Author(s)
      畠山昌則
    • Organizer
      第97回日本消化器病学会総会 シンポジウム
    • Place of Presentation
      京王プラザホテル東京、東京)
    • Year and Date
      2011-05-14
  • [Presentation] 胃癌発症におけるピロ リ菌の役割2011

    • Author(s)
      畠山昌則
    • Organizer
      第100回日本病理学会総会シンポジウム.感染・炎症と胃癌
    • Place of Presentation
      パシフィコ横浜、横浜
    • Year and Date
      2011-04-29
  • [Presentation] Carcinogenic mechanism of Helicobacter pylori2011

    • Author(s)
      畠山昌則
    • Organizer
      9th InternationalGastric Cancer Congress (IGCC 2011).Symposium.
    • Place of Presentation
      Coex Center,Seoul, South Korea)
    • Year and Date
      2011-04-21
  • [Presentation] ピロリ菌感染と胃癌2011

    • Author(s)
      畠山昌則
    • Organizer
      東京都港区医師会内科会 学術講演会
    • Place of Presentation
      港区医師会館、東京
    • Year and Date
      2011-03-23
  • [Presentation] 胃発癌の分子メカニズム"2011

    • Author(s)
      畠山昌則
    • Organizer
      第7回日本消化管学会総会学術集会・招待講演
    • Place of Presentation
      国立京都国際会議場、京都
    • Year and Date
      2011-02-19
  • [Presentation] ヘリコバクター・ピロリによる胃癌発症の分子機構2011

    • Author(s)
      畠山昌則
    • Organizer
      第30回茨城県消化管病態研究会(つくばリサーチセミナー)/第 2 回茨城ヘリコバクター研究会
    • Place of Presentation
      オークラフロンティアホテルつくば、つくば市
    • Year and Date
      2011-02-16
  • [Presentation] Helicobacter pylori andgastric cancer2011

    • Author(s)
      畠山昌則
    • Organizer
      The 26th NagoyaInternational cancer Treatment Symposium? Current Trends in Translational Medicine.
    • Place of Presentation
      愛知県がんセンター研究所、名古屋
    • Year and Date
      2011-02-12
  • [Presentation] 胃がん発症における上皮極性破壊の役割2011

    • Author(s)
      畠山昌則
    • Organizer
      平成22年度がん支援活動公開シンポジウム.
    • Place of Presentation
      学術総合センタ-、東京
    • Year and Date
      2011-02-09
  • [Presentation] Role of SHP2 tyrosinephosphatase in gastric carcinogenesis2011

    • Author(s)
      畠山昌則
    • Organizer
      1stSymposium on Carcinogenic Spiral and 9thInternational Conference on ProteinPhosphatase.
    • Place of Presentation
      東京大学医学部鉄門講堂、東京
    • Year and Date
      2011-02-02
  • [Presentation] Role of Helicobacter pylori CagA oncoprotein in gastriccarcinogenesis2010

    • Author(s)
      畠山昌則
    • Organizer
      第33回日本分子生物学会年会/第 83 回日本生化学会大会 BMB 2010シンポジウム ? Protein Phosphatases:Basics and Diseases.
    • Place of Presentation
      ポートピアホテル、神戸
    • Year and Date
      2010-12-08
  • [Presentation] Helicobacter pylori CagAoncoprotein and gastric carcinoma2010

    • Author(s)
      畠山昌則
    • Organizer
      Frontiers in Cancer Research 2010 .
    • Place of Presentation
      National University ofSingapore, Singapore
    • Year and Date
      2010-11-10
  • [Presentation] CagA positive H. pylori inthe pathogenesis of gastric cancer2010

    • Author(s)
      畠山昌則
    • Organizer
      18thUnited European gastroenterology Week(UEGW 2010) Symposium Insights intogastric cancer pathogenesis.
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2010-10-26
  • [Presentation] ピロリ菌発がんが紐解く類移動史2010

    • Author(s)
      畠山昌則
    • Organizer
      お茶の水がん学アカデミア第67回集会
    • Place of Presentation
      順天堂大学医学部、東京
    • Year and Date
      2010-10-07
  • [Presentation] ヘリコバクター ・ ピロ リ菌がんタンパク質CagAの胃上皮細胞内移行メカニズム2010

    • Author(s)
      畠山昌則
    • Organizer
      第69回日本癌学会総会モーニングレクチャー
    • Place of Presentation
      大阪国際会場、大阪
    • Year and Date
      2010-09-23
  • [Presentation] ピロリ菌がんタンパク質CagAによる胃がん発症の分子機構2010

    • Author(s)
      畠山昌則
    • Organizer
      第61回日本電気泳動学会総会・特別講演
    • Place of Presentation
      北海道大学クラーク会館講堂、札幌
    • Year and Date
      2010-09-18
  • [Presentation] ピロリ菌による胃発がんメカニズム" 創薬薬理フォーラム2010

    • Author(s)
      畠山昌則
    • Organizer
      第18回シンポジウム
    • Place of Presentation
      日本薬学会・長井記念館、東京
    • Year and Date
      2010-09-16
  • [Presentation] ピロリ菌感染症としての胃がん2010

    • Author(s)
      畠山昌則
    • Organizer
      第1回白金カンファレンス
    • Place of Presentation
      白金台、東京
    • Year and Date
      2010-09-10
  • [Presentation] Helicobacter pylori CagA asa bacterial oncoprotein2010

    • Author(s)
      畠山昌則
    • Organizer
      9th SurugadaiSymposium at the Tokyo Medical and Dental University
    • Place of Presentation
      東京医科歯科大学、東京
    • Year and Date
      2010-09-08
  • [Presentation] 胃癌発生にお けるヘリコバクター・ピロリの役割2010

    • Author(s)
      畠山昌則
    • Organizer
      第7回日本病理学会カンファレンス
    • Place of Presentation
      岡山 コンベンションセンタ-、岡山
    • Year and Date
      2010-08-06
  • [Presentation] ピロリ菌癌タンパク質CagAの細胞内移行ならびに病原活性発現機構2010

    • Author(s)
      畠山昌則
    • Organizer
      第16回日本消化器病学会関東支部教育講演会
    • Place of Presentation
      砂防会館、東京
    • Year and Date
      2010-07-11
  • [Presentation] ヘリコバクター ・ ピロ リの発癌メカニズム2010

    • Author(s)
      畠山昌則
    • Organizer
      第7回東京上部消化管勉強会.
    • Place of Presentation
      京王プラザホテル、東京
    • Year and Date
      2010-07-07
  • [Presentation] Mechanisms for delivery andpathogenic action of the Helicobacterpylori CagA oncoprotein2010

    • Author(s)
      畠山昌則
    • Organizer
      The 17th SeoulInternational Cancer Symposium Gastriccancer
    • Place of Presentation
      Seoul, SouthKorea
    • Year and Date
      2010-06-01
  • [Presentation] Helicobacter pylori andgastric carcinogenesis2010

    • Author(s)
      畠山昌則
    • Organizer
      The 7th SNU/U-Tokyo Med. Joint Conference
    • Place of Presentation
      Seoul, South Korea
    • Year and Date
      2010-05-28
  • [Presentation] ピロリ菌と胃癌2010

    • Author(s)
      畠山昌則
    • Organizer
      第2回新適塾「難病への挑戦
    • Place of Presentation
      千里ライフサイエンスセンタ-、大阪
    • Year and Date
      2010-05-25
  • [Presentation] Helicobacter pylori andmolecular pathogenesis2010

    • Author(s)
      畠山昌則
    • Organizer
      AmericanAssociation for cancer Research (AACR) 101st Annual Meeting 2010.
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2010-04-20

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Published: 2014-08-29  

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