2013 Fiscal Year Final Research Report
Coupling between Deformations of Vesicle and Chemical Stimuli: Approach from Soft Matter toward Cellular Life
| Project/Area Number |
22244053
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biophysics/Chemical physics
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| Research Institution | Tohoku University (2012-2013)
Ochanomizu University (2010-2011) |
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Principal Investigator |
MASAYUKI Imai 東北大学, 理学(系)研究科(研究院), 教授 (60251485)
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| Co-Investigator(Kenkyū-buntansha) |
URAKAMI Naohito 山口大学, 大学院理工学研究科, 准教授 (50314795)
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| Project Period (FY) |
2010-05-31 – 2014-03-31
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| Keywords | 生命現象の物理 |
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| Research Abstract |
We have investigated vesicle deformations triggered by chemical stimuli to reveal the pathway from vesicles (molecular assemblies of lipids) to cellular life. First we established an experimental technique to examine vesicle deformation triggered by the chemical stimuli and then revealed a mechanism of a tubular membrane formation induced by pH gradient. In addition we found that chemical stimuli drive vesicles toward the chemical source, so-called chemophoresis. These observations clearly show that the chemical stimuli play important roles to develop cellular life from vesicle. In addition we succeeded to reproduce a self-production of vesicle using binary vesicles, which shed light on the pathway toward the protopcell.
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