2012 Fiscal Year Final Research Report
Novel electrode array device for electrochemical imaging
| Project/Area Number |
22245011
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Analytical chemistry
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| Research Institution | Tohoku University |
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Principal Investigator |
MATSUE Tomokazu 東北大学, 原子分子材料科学高等研究機構, 教授 (70173797)
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| Co-Investigator(Kenkyū-buntansha) |
SHIKU Hitoshi 東北大学, 大学院・環境科学研究科, 准教授 (10361164)
INO Kosuke 東北大学, 大学院・環境科学研究科, 助教 (00509739)
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| Project Period (FY) |
2010 – 2012
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| Keywords | バイオセンサー |
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| Research Abstract |
In this study, we have proposed a novel method for electrochemical imaging using local redox cycling-based electrochemical (LRC-EC) devices and systems. In the device, two arrays of microelectrodes are orthogonally arranged to fabricate an n × n array of crossing points (measurement points) with only 2n bonding pads for external connection. The crossing points of the column and row electrodes can easily be addressed by setting the proper potentials at the column and row electrodes to induce local redox cycling at desired crossing points. Therefore, the crossing points can be used as individual electrochemical sensors. This addressable and multiple detection system successfully applied for the detection of enzyme activity, gene-expression analysis, cell differentiation analysis, DNA detection and dynamic analyses of droplets. The present LRC-EC system will be widely applicable for various bioimaging and biosensing.
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Research Products
(23 results)
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[Journal Article] Topographical and electrochemical nanoscale imaging of living cells using voltage switching mode scanning electrochemical microscopy2012
Author(s)
Yasufumi Takahashi, Andrew I. Shevchuk, Pavel Novak, Babak Babakinejad, Julie Macpherson, Patrick R. Unwind, Hitoshi Shiku, Julia Gorelik, David Klenerman, Yuri E. Korchev, Tomokazu Matsue
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Journal Title
Proceedings of the National Academy of Sciences of the United States of America
Volume: Vol. 109, No. 29
Pages: 11540-11545
DOI
Peer Reviewed
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[Journal Article] David Klenerman, Yuri E. Korchev1, Multifunctional nanoprobes for nanoscale chemical imaging and localized chemical delivery at surfaces and interfaces2011
Author(s)
Yasufumi Takahashi, Andrew I. Shevchuk, Pavel Novak, Yanjun Zhang, Neil Ebejer, Julie V. Macpherson, Patrick R. Unwin, Andrew J. Pollard, Debdulal Roy, Charles A. Clifford, Hitoshi Shiku, Tomokazu Matsue
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Journal Title
Angewandte Chemie International Edition
Volume: 50
Pages: 9638-9642
DOI
Peer Reviewed
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[Patent(Industrial Property Rights)] ウェルユニット及び電気化学的分 析方法2010
Inventor(s)
青柳重夫, 内海陽介, 末永智一, 珠 玖仁, 阿部宏之, 河野浩之, 柏崎 寿宣, 星宏良, 星翼
Industrial Property Rights Holder
青柳重夫, 内海陽介, 末永智一, 珠 玖仁, 阿部宏之, 河野浩之, 柏崎 寿宣, 星宏良, 星翼
Industrial Property Number
特許、特願2010-208817
Filing Date
2010-09-17
