Research of Reductive Catalytic Asymmetric Synthesis

2014 Fiscal Year Final Research Report

• Project/Area Number: 22245014
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Synthetic chemistry
• Research Institution: Nagoya University
• Principal Investigator: NISHIYAMA HISAO 名古屋大学, 工学(系)研究科(研究院), 教授 (40135421)
• Co-Investigator(Kenkyū-buntansha): ITO Junichi 名古屋大学, 大学院工学研究科, 講師 (20402480) ; YAMAMOTO Yoshihiko 名古屋大学, 大学院創薬科学研究科, 教授 (60283412)
• Project Period (FY): 2010-04-01 – 2015-03-31
• Keywords: 有機合成 / 不斉触媒 / 不斉合成 / 遷移金属錯体

Outline of Final Research Achievements

New transition metal complexes were applied to reductive coupling reactions, which can be used for asymmetric conjugate hydrosilylation, hydrosilylative reduction of ketones, borylation of alkenes or unsaturated carbonyl groups. Using bis(oxazolinyl)phenyl rhodium or ruthenium complexes, high enatioselectivities were attained. Especially asymmetric diboration provided useful organic compound, 1,2-diol, as precursor for pharmaceutical materials. Furthermore, new iron or cobalt complexes with bis(oxazolinyl)phenyl ligands were prepared and studied on their stability and catalytic activity. In addition, new NNO type chiral ligand, binaphthyl-phenantrolines, were developed for asymmetric catalysis such as zinc catalyzed alkylation, and intramolecular hydrosilylation providing chiral silicone compounds in high enantioselectivity.

Free Research Field

有機合成化学