Mass spectrometry for high-mass molecules using superconducting nano-strip line detectors

2013 Fiscal Year Final Research Report

• Project/Area Number: 22246056
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Measurement engineering
• Research Institution: National Institute of Advanced Industrial Science and Technology
• Principal Investigator: OHKUBO Masataka 独立行政法人産業技術総合研究所, つくばイノベーションアリーナ推進本部, 上席イノベーションコーディネータ (60356623)
• Co-Investigator(Kenkyū-buntansha): YOSHIKAWA Nobuyuki 横浜国立大学, 大学院工学研究院, 教授 (70202398)
• Co-Investigator(Renkei-kenkyūsha): UKIBE Masahiro 産業技術総合研究所, 計測フロンティア研究部門, 主任研究員 (00344226) ; SHIKI Shigetomo 産業技術総合研究所, 計測フロンティア研究部門, 主任研究員 (50342796) ; ZEN Nobuyuki 産業技術総合研究所, 計測フロンティア研究部門, 研究員 (20455439) ; KAORI Kamoshida 産業技術総合研究所, 計測フロンティア研究部門, 招聘研究員 (50415775)
• Project Period (FY): 2010-04-01 – 2014-03-31
• Keywords: 超伝導検出器 / 質量分析 / 単一磁束量子 / 先端計測 / ペプチド / タンパク質 / 生体分子 / 飛行時間

Research Abstract

Ion detection at 1 ns pulse width for single ions and 1 cm sensitive area has been realized with superconducting nano-strip ion detector (SSID). Superconducting tunnel junction detectors operate at 0.3 K, whereas SSID operate at 4 K that can be reached by using a pulse tube cooler without liquid helium supply.
In order to measure time-of-flight of ions, we developed superconducting time-to-digital converter (TDC) using single flux quantum (SFQ). With a combination of SSID and SFQ-TDC, analog pulse signal can be converted to digital signal that is transmitted to room temperature.

Research Products

• [Journal Article] Ion-induced dynamical change of supercurrent flow in superconducting strip ion detectors with parallel configuration (2014)
  • Author(s): N. Zen, S. Shiki, M. Ukibe, M. Koike and M. Ohkubo
  • Journal Title: Appl. Phys. Lett Volume: 104 Pages: 012601
  • DOI: 10.1063/1.4861225
• [Journal Article] Superconducting Tunnel Junction Detectors for Analytical Sciences (2014)
  • Author(s): M. Ohkubo, S. Shiki, M. Ukibe, G. Fujii, N. Matsubayashi
  • Journal Title: IEEE Trans, Appl. Super Volume: 24 Pages: 2400208
  • DOI: 10.1109/TASC.2014.2318316
• [Journal Article] Design and High-Speed Tests of a Single-Flux-Quantum Time-to- Digital Converter for Time-of-Flight Mass Spectrometry (2014)
  • Author(s): K. Sano, et al
  • Journal Title: Superconductive Electronics Conference (ISEC), 2013 IEEE 14th International Volume: 7-11 Pages: 1-3
  • DOI: 10.1109/ISEC.2013.6604259
• [Journal Article] A2 x 2mm^2 superconducting strip-line detector for high-performance time-of-flight mass spectrometry (2012)
  • Author(s): A. Casaburi, E. Esposito, M. Ejrnaes, K. Suzuki, M. Ohkubo, S. Pagano, R. Cristiano
  • Journal Title: Supercond. Sci. Tech Volume: 25 Pages: 115004
  • DOI: 10.1088/0953-2048/25/11/115004
• [Journal Article] Thicker, more efficient superconducting strip-line detectors for high throughput macromolecules analysis (2011)
  • Author(s): A. Casaburi, M. Ejrnaes, N. Zen, M. Ohkubo, S. Pagano, and R. Cristiano
  • Journal Title: Appl. Phys. Lett Volume: 98 Pages: 023702
  • DOI: 10.1063/1.3537808
• [Journal Article] Hot-spot detection model in superconducting nano-stripline detector for keV ions (2011)
  • Author(s): K. Suzuki, S. Shiki, M. Ukibe, M. Koike, S. Miki, Z. Wang, and M. Ohkubo
  • Journal Title: Appl. Phys. Express Volume: 4 Pages: 083101
  • DOI: 10.1143/APEX.4.083101
• [Journal Article] Charge-state-derivation ion detection using a superconducting nanostructure device for mass spectrometry (2010)
  • Author(s): K. Suzuki, M. Ohkubo, M. Ukibe, K. Chiba-Kamoshida, S. Shiki, S. Miki, Z. Wang
  • Journal Title: Rapid Commun. Mass Spectrom Volume: 24 Pages: 3290
  • DOI: 10.1002/rcm.4780
• [Presentation] 超伝導ナノストリップイオン検出器(SSID)の出力波高値分布の改善 (2014)
  • Author(s): 全伸幸、志岐成友、藤井剛、浮辺雅宏、小池正記、大久保雅隆
  • Organizer: 第62回質量分析総合討論会
  • Place of Presentation: 大阪
  • Year and Date: 20140000
• [Presentation] Design and High-Speed Tests of a Single-Flux-Quantum Time-to-Digital Converter for Time-of-Flight Mass Spectrometry (2013)
  • Author(s): K. Sano, A. Takahashi, Y. Yamanashi, N. Yoshikawa, N. Zen, K. Suzuki, M. Ohkubo
  • Organizer: 14^<th> International Superconductive Electronics Conference (ISEC)
  • Place of Presentation: Cambridge, USA
  • Year and Date: 20130000
• [Presentation] Superconducting tunnel junction (STJ) detectors for ion-charge-number sensitive mass spectrometry (2013)
  • Author(s): M. Ohkubo, N. Zen, M. Ukibe, S. Shiki, M. Koike
  • Organizer: 14^<th> International Superconductive Electronics Conference (ISEC-14)
  • Place of Presentation: Cambridge, USA
  • Year and Date: 20130000
  • Invited
• [Presentation] Application of superconducting detectors to analytical instruments (2013)
  • Author(s): M. Ohkubo
  • Organizer: 3^<rd> International Workshop on Frontier Applications of Superconducting Devices (IWFASD2013)
  • Place of Presentation: Shanghai, China
  • Year and Date: 20130000
  • Invited
• [Presentation] 価数分離を可能にする超伝導ナノストリップイオン検出器の開発 (2013)
  • Author(s): 全伸幸、志岐成友、鈴木宏治、浮辺雅宏、小池正記、R. Cristiano、大久保雅隆
  • Organizer: 第61回質量分析総合討論会
  • Place of Presentation: つくば
  • Year and Date: 20130000
• [Presentation] Nanostructure cryodetector for mass spectrometry (2012)
  • Author(s): M. Ohkubo, K. Suzuki, N. Zen, S. Shiki, M. Ukibe, M. Koike, R. Cristiano, M. Ejrnaes, A. Casaburi, N. Yoshikawa, Y. Takahashi
  • Organizer: 60^<th> ASMS Conference on Mass Spectrometry and Allied Topics
  • Place of Presentation: Vancouver, Canada
  • Year and Date: 20120000
• [Presentation] Superconducting tunnel junction detectors for mass spectrometry (2012)
  • Author(s): M. Ohkubo, N. Zen, T. Kitazume, M. Ukibe, S. Shiki, M. Koike
  • Organizer: 1st International Workshop on Superconducting Sensors and Detectors (IWSSD2012)
  • Place of Presentation: Daejeon, Korea
  • Year and Date: 20120000
  • Invited
• [Presentation] Superconducting molecule detectors overcoming fundamental limits of conventional mass spectrometry (2011)
  • Author(s): M. Ohkubo, et al
  • Organizer: 14^<th> International Workshop on Low Temperature Detectors (LTD-14)
  • Place of Presentation: Heidelberg, Germany
  • Year and Date: 20110000
• [Presentation] True mass spectrometry realized by superconducting molecule detectors (2011)
  • Author(s): M. Ohkubo, et al
  • Organizer: 6th East Asia Symposium on Superconductor Electronics (EASSE2011)
  • Place of Presentation: Yamagata, Japan
  • Year and Date: 20110000
  • Invited
• [Presentation] Breakthrough by superconducting particle detector in mass spectrometry (2011)
  • Author(s): M. Ohkubo
  • Organizer: 26^<th> International Conference on Low Temperature Physics (LT-26)
  • Place of Presentation: Beijing, China
  • Year and Date: 20110000
  • Invited
• [Presentation] Chrge-State-Discrimination Ion Detction By Superconducting Stripline Detectors (2010)
  • Author(s): K. Suzuki, K. Chiba, S. Miki, S. Shiki, Z. Wang, M. Ohkubo
  • Organizer: International Symposium on Superconductivity (ISS2010)
  • Place of Presentation: Funabori, Tokyo
  • Year and Date: 20100000
• [Book] 現代質量分析学 (2013)
  • Author(s): 大久保雅隆(高山 光男, 早川 滋雄, 瀧浪 欣彦, 和田芳直 編)
  • Publisher: 化学同人、(分担執筆 : 7章 質量分析用検出器)
• [Book] 超伝導現象と高温超伝導体 (2013)
  • Author(s): 大久保雅隆
  • Publisher: エヌティーエス、(分担執筆 : 第7章 計測診断機器への応用)
• [Remarks]
  • URL: http://staff.aist.go.jp/m.ohkubo
• [Patent(Industrial Property Rights)] クライオスタット (2014)
  • Inventor(s): 大久保雅隆、桐原英治
  • Industrial Property Rights Holder: 産業技術総合研究所、(有)バックフィールド
  • Industrial Property Rights Type: 特許番号未定特開2011-060864
  • Patent Publication Number: 特開2011-060864
  • Acquisition Date: 2014-05-30
  • Overseas
• [Patent(Industrial Property Rights)] イオン価数弁別高速粒子検出器 (2011)
  • Inventor(s): 大久保雅隆、鈴木宏治
  • Industrial Property Rights Holder: 産業技術総合研究所
  • Industrial Property Rights Type: 特許医
  • Industrial Property Number: PCT/JP2011/052407
  • Filing Date: 2011-02-04
  • Overseas