2013 Fiscal Year Final Research Report
Evolution and meanings of genomic wastelands (RCRO)
| Project/Area Number |
22247037
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Physical anthropology
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
GOJOBORI Jun 総合研究大学院大学, 先導科学研究科, 助教 (00506800)
MIYABE Takako 京都大学, 霊長類研究所, 助教 (10437288)
TANABE Hideyuki 総合研究大学院大学, 先導科学研究科, 助教 (50261178)
GO Yasuhiro 大学共同利用機関法人自然科学研究機構(新分野創成センター), 新分野創成センター, 准教授 (50377123)
KOGA Akihiko 京都大学, 霊長類研究所, 教授 (80192574)
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| Project Period (FY) |
2010-04-01 – 2014-03-31
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| Keywords | RCRO |
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| Research Abstract |
We focused on constitutive heterochromatin (RCRO) that positively concerns to rearrangements of genome, and performed molecular dissection and estimated biological meaning of RCRO. We developed a new technique to analyze repetitive sequences and analyzed the component and construction of RCRO. Especially, subterminal satellite and alpha satellite DNA were investigated in chimpanzees, gibbons, and owl monkeys. Incredible differentiations were found in them. We found following results: 1) Gibbons have alpha satellite DNA not only at centromeres but also at telomeres. 2) Owl monkeys showed that 3 structures of alpha satellite DNA are related to change of chromosome number and one of them have some concerns with the nocturnal. 3) Chimpanzees allowed us to postulate that RCRO restrains ectopic recombinations from comparisons with results found previously. These outcomes interestingly enable us to be aware some concerns among biological evolution and chromosome reaaramgements.
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[Journal Article] Regional DNA methylation differences between humans and chimpanzees are associated with genetic changes, transcriptional divergence and disease genes2013
Author(s)
Fukuda K, Ichiyanagi K, Yamada Y, Go Y, Udono T, Wada S, Maeda T, Soejima H, Saitou N, Ito T, Sasaki H
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Journal Title
J. Hum Genet
Volume: 58
Pages: 446-454
DOI
Peer Reviewed
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[Journal Article] Activation of the long terminal repeat of human endogenous retrovirus K by melanoma-specific transcription factor MITF-M2011
Author(s)
Katoh I, Mirova A, Kurata S, Murakami Y, Horikawa K, Nakakuki N, Sakai T, Hashimoto K, Maruyama A, Yonaga T, Fukunishi N, Moriishi K, Hirai H
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Journal Title
Neoplasia
Volume: 13
Pages: 1081-1092
DOI
Peer Reviewed
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