Phytophthora mating hormones: chemical biological studies including their receptors

2014 Fiscal Year Final Research Report

• Project/Area Number: 22248012
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Bioproduction chemistry/Bioorganic chemistry
• Research Institution: Nagoya University
• Principal Investigator: OJIKA Makoto 名古屋大学, 生命農学研究科, 教授 (50152492)
• Co-Investigator(Kenkyū-buntansha): 矢島 新 東京農業大学, 応用生物科学部, 准教授 (30328546)
• Co-Investigator(Renkei-kenkyūsha): 坂神 洋次 名古屋大学, 大学院生命農学研究科, 教授 (80107408)
• Project Period (FY): 2010-04-01 – 2015-03-31
• Keywords: 疫病菌 / Phytophthora / 交配ホルモン / 受容体

Outline of Final Research Achievements

Phytophthora is a genus that infects and damages important crops such as potatoes and tomatoes. This phytopathogen sexually reproduces using mating hormones (alpha 1 and alpha 2), which are secreted by A1 and A2 mating types, respectively. The identification of the mating hormones had been a long-pending problem. In this project, we determined the chemical structures of these mating hormones, clarified the structure-activity relationship, biosynthetic process, and hormone universality. Furthermore, to identify the hormone receptors, fluorescent probes of alpha 1 were synthesized and found to selectively stain the A2 mating type, which could furnish alpha 1 receptor.

Free Research Field

天然物化学