2014 Fiscal Year Final Research Report
Regulation of plant immune responses by pattern recognition receptors
| Project/Area Number |
22248041
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied molecular and cellular biology
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| Research Institution | Meiji University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KAKU Hanae 明治大学, 農学部, 教授 (70409499)
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| Project Period (FY) |
2010-04-01 – 2015-03-31
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| Keywords | パターン認識受容体 / 植物免疫 / シグナル伝達 / エリシター / キチン |
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| Outline of Final Research Achievements |
Plant immune signaling mediated by chitin receptor was the subject of this project. Molecular mechanism of ligand-induced receptor dimerization and activation was clarified by biochemical and NMR studies. CERK1 autophosphorylation sites required for chitin responses were also identified. A cytoplasmic receptor-like kinase (RLK), PBL27, was shown to regulate chitin-induced gene expression and callose accumulation. It was also suggested that the signaling receptor kinases choose downstream RLKs based on their substrate specificity. Structural basis for the switching of defense and symbiotic responses by the kinase domains of LysM receptors was clarified. Dual function of a LysM receptor, OsCERK1, in defense and mycorhizal symbiosis was revealed, indicating close evolutional relationships of LysM receptors serving for these apparently opposite responses.
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| Free Research Field |
農学・境界農学・応用分子細胞生物学
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