2012 Fiscal Year Final Research Report
Efficient Synthesis of Biologically Active Natural Products Useful for Drug Discovery
| Project/Area Number |
22249001
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Nagasaki University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ISHIHARA Jun 長崎大学, 医歯薬学総合研究科, 准教授 (80250413)
TAKAHASHI Keisuke 長崎大学, 医歯薬学総合研究科, 助教 (60380854)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 全合成 / 天然物 |
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| Research Abstract |
We have studied on the total synthesis of natural products having intriguing biological activities useful for drug discovery. As a result, we have achieved the total syntheses of oxazolomycin A and kitocephalin, and the formal synthesis of welwistatin. In addition, we have developed a new methodology for the construction of heterocycles which relies on a Rh(II)-catalyzed C-H amination reaction, and have achieved the total syntheses of NW-G01, englerin A, and inthomycin A, B, C.
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Research Products
(23 results)
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[Presentation] Total Synthesis of Chloptosin2010
Author(s)
Setsuya Shibahara, Takaaki Matsubara, Keishke Takahashi, Jun Ishihara, Susumi Hatakeyama
Organizer
The 2010 International Chemical Congressof Pacific Basin Societies
Place of Presentation
Hawaii (USA)
Year and Date
2010-12-19
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