Role of Brain-Gut Peptides in Pathophysiology of Brain-Gut Interactions

2014 Fiscal Year Final Research Report

• Project/Area Number: 22249024
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General internal medicine (including Psychosomatic medicine)
• Research Institution: Tohoku University
• Principal Investigator: FUKUDO Shin 東北大学, 医学(系)研究科(研究院), 教授 (80199249)
• Co-Investigator(Kenkyū-buntansha): KANAZAWA Motoyori 東北大学, 大学院医学系研究科, 准教授 (70323003)
• Project Period (FY): 2010-04-01 – 2015-03-31
• Keywords: 脳腸相関 / 過敏性腸症候群 / CRH / 消化管知覚 / 消化管運動 / 脳画像 / CRH-R1 / CRH拮抗薬

Outline of Final Research Achievements

In patients with irritable bowel syndrome (IBS), stress response in the central nervous system and gastrointestinal tract is exaggerated. We tested the hypothesis that corticotropin-releasing hormone (CRH) plays a major role in pathogenesis of IBS. In both humans and animals, visceral stress evoked release of brain-gut peptides especially CRH in the regional brain (e.g. amygdala, anterior cingulate cortex, insula, paraventricular nucleus, and midbrain). These results suggest that regional release of CRH in the specific sites in the brain may be the most important part of pathophysiology of IBS.

Free Research Field

心身医学