2013 Fiscal Year Final Research Report
Dynamics of stress-homeosurveillance and its relevance to disease control
| Project/Area Number |
22249025
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (A)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
General internal medicine (including Psychosomatic medicine)
|
|---|
| Research Institution | University of Occupational and Environmental Health, Japan |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KOUNO Kimitoshi 産業医科大学, 医学部, 名誉教授 (00153479)
UENO Youichi 産業医科大学, 医学部, 教授 (10232745)
SAKAI Noriaki 産業医科大学, 医学部, 教授 (90248576)
|
|---|
| Project Period (FY) |
2010-04-01 – 2014-03-31
|
| Keywords | ストレス科学 / ホメオサーベイランス / 酸化ストレス / 生存脳 / 神経伝達物資 / 免疫伝達物質 |
|---|
| Research Abstract |
Vital homeosurveillance is performed by receiving input signals through stress-sensors and by sending output signals to metabolic and immune systems. This study has been undertaken to clarify the dynamism in homeosurveillance by elucidating (1) the input signaling mechanisms of stress-sensing such as pain, mechanic and oxidative stress to vital brain centers including hypothalamus and (2) the output signaling mechanisms from brain centers to immune, inflammatory and bone metabolic systems in physiologic condition and disease models. The output signals via PTH/PTHrP and synthetic neurons commit to differentiation of stem cells or naïve cells to particular direction, which is involved in disease processes. Furthermore, results using disease models in which the dynamism in homeosuriveillance was regulated would bring novel strategies of disease control.
|
-
-
-
[Journal Article] Effects of food deprivatation on the hypothalamic feeding-regulating peptides gene expressions in serotonin depleted rats2014
Author(s)
Yoshimura M, Hagimoto M, Matsuura T, Ohkubo J, Ohno M, Maruyama T, Ishikura T, Hashimoto H, Kakuma T, Yoshimatsu H, Terawaki K, Uezono Y, Toyohira Y, Yanagihara N, Ueta Y
-
Journal Title
The Journal of Physiological Science
Volume: 64(2)
Pages: 97-104
-
-
-
-
-
-
-
[Journal Article] A JAK inhibitor tofacitinib regulates synovitis through inhibition of IFN- □ and IL-17 production by human CD4+ T cells2012
Author(s)
Maeshima K, Yamaoaka K Kubo s, Nakano K, Iwata S, Saito K, Ohishi M, Miyahara H, Tanaka S, Ishi K, Yoshimatsu H, Tanaka Y
-
Journal Title
Arthritis Rheum
Volume: 64
Pages: 1790-1798
-
-
[Journal Article] Expression of the c-fos-monomeric red fluorescent protein 1 fusion gene in the spinal cord and the hypothalamic paraventricular nucleus in transgenic rats after nociceptive stimulation2012
Author(s)
Ishikura, T. Suzuki, H. Yoshimura, M. Ohkubo, J. Katoh, A. Ohbuchi, T. Ohno, M. Fujihara, H. Kawasaki, M. Ohnishi, H. Nakamura, T. & Ueta, Y
-
Journal Title
Brain Research
Volume: 1479
Pages: 52-61
-
-
-
[Journal Article]
Author(s)
Oshita K, Yamaoka K, Udagawa N, Fukuyo S, Sonomoto K, Maeshima K, Kurihara R, Nakano K, Saito
-
