Characterization of tumorigenic stem cells in myeloid neoplasms

2012 Fiscal Year Final Research Report

• Project/Area Number: 22249039
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Hematology
• Research Institution: Kyushu University
• Principal Investigator: AKASHI Koichi 九州大学, 医学研究院, 教授 (80380385)
• Co-Investigator(Kenkyū-buntansha): MIYAMOTO Toshihiro 九州大学, 大学病院, 講師 (70343324) ; TAKENAKA Katsuto 九州大学, 大学病院, 講師 (30301295) ; IWASAKI Hiromi 九州大学, 大学病院, 准教授 (20403925)
• Project Period (FY): 2010 – 2012
• Keywords: 腫瘍性幹細胞 / 骨髄増殖性腫瘍 / 骨髄異形成症候群 / 異種移植 / マクロファージ寛容

Research Abstract

To understand the property of tumorigenic stem cells in diverse myeloid neoplasms, it is necessary to develop an efficient xenotransplant model. We established a novel immunodeficient mouse strain that possessed a high capability to reconstitute human hem

Research Products

• [Journal Article] TIM-3 as a therapeutic target for malignant stem cells in acute myelogenous leukemia (2013)
  • Author(s): Kikushige Y, Akashi K
  • Journal Title: Ann NY Acad Sci Volume: 1266 Pages: 118-123
  • DOI: DOI:10.1111/j.1749-6632.2012.06550.x.
  • Peer Reviewed
• [Journal Article] Polymorphic Sirpa is the genetic determinant for NOD-based mouse lines to achieve efficient human cell engraftment. (2013)
  • Author(s): Yamauchi T, Takenaka K, Urata S, Shima T, Kikushige Y, Tokuyama T, Iwamoto C, Nishihara M, Iwasaki H, Miyamoto T, Honma N, Nakao M, Matozaki T, Akashi K.
  • Journal Title: Blood Volume: 121(8) Pages: 1316-1325
  • DOI: DOI:10.1182/blood-2012-06-440354
  • Peer Reviewed
• [Journal Article] Quantitation of hematogones at the time of engraftment is a useful prognostic indicator in allogeneic hematopoietic stem cell transplantation (2013)
  • Author(s): Shima T, Miyamoto T, Kikushige Y, Mori Y, Kamezaki K, Takase K, Henzan H, Numata A, Ito Y, Takenaka K, Iwasaki H, Kamimura T, Eto T, Nagafuji K, Teshima T, Kato K, Akashi K.
  • Journal Title: Blood Volume: 121(5) Pages: 840-848
  • DOI: DOI:10.1182/blood-2012-02-409607
  • Peer Reviewed
• [Journal Article] Engulfment of hematopoietic stem cells caused by down-regulation of CD47 is critical in the pathogenesis of hemophagocytic lymphohistiocytosis. (2012)
  • Author(s): Kuriyama T, Takenaka K, Kohno K, Yamauchi T, Daitoku S, Yoshimoto G, Kikushige Y, Kishimoto J, Abe Y, Harada N, Miyamoto T, Iwasaki H, Teshima T, Akashi K
  • Journal Title: Blood Volume: 120(19) Pages: 4058-4067
  • DOI: DOI:10.1182/blood-2012-02-408864.
  • Peer Reviewed
• [Journal Article] Self-renewing hematopoietic stem cell is theprimary target in pathogenesis ofhuman chron is lymphocytic leukemia (2011)
  • Author(s): Kikushige Y, Ishikawa F, Miyamoto T, Shima T, Urata S, Yoshimoto G, Mori Y, Iino T, Yamauchi T, Eto T, Niiro H, Iwasaki H, Takenaka K, Akashi K.
  • Journal Title: Cancer Cell Volume: 20(2) Pages: 246-259
  • DOI: DOI:10.1016/j.ccr.2011.06.029.
  • Peer Reviewed
• [Journal Article] JAK2 V617F uses distinct signalling pathways to induce cell proliferation and neutrophil activation. (2011)
  • Author(s): Oku S, Takenaka K, Kuriyama T, Shide K, Kumano T, Kikushige Y, Urata S, Yamauchi T, Iwamoto C, Shimoda HK, Miyamoto T, Nagafuji K, Kishimoto J, Shimoda K, Akashi K.
  • Journal Title: Br J Haematol Volume: 150(3) Pages: 334-344
  • DOI: DOI:10.1111/j.1365-2141.2010.08249.x
  • Peer Reviewed
• [Journal Article] TIM-3 is a promising target to selectively kill acute myeloid leukemia stem cells. (2010)
  • Author(s): Kikushige Y, Shima T, Takayanagi SI, Urata S, Miyamoto T, Iwasaki H, Takenaka K, Teshima T, Tanaka T, Inagaki Y, Akashi K.
  • Journal Title: Cell Stem Cell Volume: 7(6) Pages: 708-717
  • DOI: DOI:10.1016/j.stem.2010.11.014.
  • Peer Reviewed
• [Presentation] Transcription factor regulation of normal and malignant hematopoiesis. (2013)
  • Author(s): Akashi K
  • Organizer: 2013 USA-Japan Science Conference
  • Place of Presentation: Hawaii,USA
  • Year and Date: 2013-03-26
• [Presentation] 悪性造血器腫瘍における癌幹細胞の病理 (2012)
  • Author(s): 赤司浩一
  • Organizer: 第71回日本癌学会
  • Place of Presentation: 札幌
  • Year and Date: 2012-09-21
• [Presentation] 慢性リンパ性白血病幹細胞の特性と治療応用 (2012)
  • Author(s): 赤司浩一
  • Organizer: 第10回日本臨床腫瘍学会
  • Place of Presentation: 大阪
  • Year and Date: 2012-07-28
• [Presentation] 造血器悪性幹細胞の成立機序 (2012)
  • Author(s): 赤司浩一
  • Organizer: 第101回日本病理学会
  • Place of Presentation: 東京
  • Year and Date: 2012-04-26
• [Presentation] Transcription factor regulation in normal and malignant hematopoiesis. (2011)
  • Author(s): Akashi K
  • Organizer: 第53回米国血液学会
  • Place of Presentation: SanDiego,USA
  • Year and Date: 20111200
• [Presentation] Origin of leukemic stem cells (2011)
  • Author(s): Akashi K
  • Organizer: ドイツ造血幹細胞学会
  • Place of Presentation: Tubingen,Gemmany
  • Year and Date: 20110900
• [Presentation] Leukemic stem cells (2011)
  • Author(s): Akashi K
  • Organizer: 第16回ヨーロッパ血液学会
  • Place of Presentation: London,UK
  • Year and Date: 20110700
• [Presentation] 白血病幹細胞を考える (2010)
  • Author(s): 赤司浩一
  • Organizer: 第72回日本血液学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2010-09-24
• [Remarks] 九州大学第一内科
  • URL: http://www.lnai.med.kyushu-.ac.Jp
• [Remarks] 新学術領域研究「癌幹細胞を標的とする腫瘍根絶技術の新構築」
  • URL: http://www.cancer-tem-ell.com