2013 Fiscal Year Final Research Report
Comprehensive study of an implantable total artificial heart using continuous flow blood pump
| Project/Area Number |
22249053
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | The University of Tokyo |
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Principal Investigator |
ABE Yusuke 東京大学, 医学(系)研究科(研究院), 准教授 (90193010)
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| Co-Investigator(Renkei-kenkyūsha) |
ONO Minoru 東京大学, 大学院医学系研究科, 教授 (40270871)
ISIYAMA Takashi 東京大学, 大学院医学系研究科, 講師 (20302789)
SAITO Itsuro 東京大学, 大学院医学系研究科, 特任研究員 (80334225)
IMACHI Kou 東京大学, 大学院医学系研究科, 名誉教授 (10010076)
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| Research Collaborator |
NAKAGAWA Hidemoto (40311667)
INOUE Yusuke 東京大学, 大学院工学系研究科, 特任研究員 (80611079)
SHI Wei サクラ精機株式会社
ISHII Kohei 香川高等専門学校, 機械電子工学科, 助教
中野 英美子 東京医科歯科大学, 医学部付属病院, MEセンター
HOSODA Kyohei 株式会社サンメディカル技術研究所
OHASHI Kouki 日本光電工業株式会社
WU Sheng-yuan ソフトバンク株式会社
ARIYOSHI Kouki 東京大学, 大学院医学系研究科, 大学院生
HARA Shintaro 東京大学, 大学院医学系研究科, 大学院生
LI Xin-yang 東京大学, 大学院医学系研究科, 大学院生
SATO Masami 東京大学, 大学院医学系研究科, 大学院生
KAWASE Yukino 北里大学, 大学院医療系研究科, 大学院生
YURIMOTO Terumi 東京大学, 大学院医学系研究科, 大学院生
MURAKAMI Haruka 東京大学, 大学院医学系研究科, 大学院生
ONO Toshiya 東京大学, 大学院医学系研究科, 技術専門員
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| Project Period (FY) |
2010-04-01 – 2014-03-31
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| Keywords | 完全人工心臓 / 連続流ポンプ / 生理的制御 / 圧センサー / ハイブリッド |
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| Research Abstract |
The total artificial heart (TAH) is expected to be an ultimate device for heart replacement. To develop small-size implantable TAH with high performance, improvement of the undulation pump TAH and development of the helical flow TAH (HFTAH) that is a next generation TAH were performed. The newly developed HFTAH was implanted in goats and 100 days of maximum survival was obtained by providing 1/R control that is a physiological control method of the TAH. In the experiment of treadmill exercise with the nonpulsatile TAH, there found no obvious difference between pulsatile and nonpulsatile TAHs. To develop an implantable controller, calibration method of implantable pressure sensor (IPS) and estimation logic of mean atrial pressure using IPS were performed. To improve biological compatibility of device parts, the hybrid parts constructed with fusion of artificial material and biological material were developed.
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[Journal Article] Computational fluid dynamics analysis of the pump parameters in the helical flow pump2014
Author(s)
Hosoda K, Ishii K, Isoyama T, Saito I, Inoue Y, Ariyoshi K, Ono T, Nakagawa H, Imachi K, Kumagai H, Abe Y
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Journal Title
J Artif Organs
Volume: 17
Pages: 9-15
DOI
Peer Reviewed
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[Journal Article] The helical flow total artificial heart : implantation in goats2013
Author(s)
Abe Y, Ishii K, Isoyama T, Saito I, Inoue Y, Sato M, Hara S, Hosoda K, Ariyoshi K, Nakagawa H, Ono T, Fukazawa K, Ishihara K, Imachi K
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Journal Title
Proc 35th Ann Intern Conf IEEE EMBS
Pages: 2720-2723
Peer Reviewed
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[Journal Article] Pulsatile driving of the helical flow pump2013
Author(s)
Ishii K, Hosoda K, Isoyama T, Saito I, Ariyoshi K, Inoue Y, Sato M, Hara S, lee X, Wu S, Ono T, Nakagawa H, Imachi K, Abe Y
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Journal Title
Proc 35th Ann Intern Conf IEEE EMBS
Pages: 2724-2727
Peer Reviewed
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[Journal Article] Relation between left atrial pressure and the corresponding pulse pressure in the helical flow total artificial heart2013
Author(s)
Wu S-Y, Saito I, Isoyama T, Inoue Y, Ishii K, Sato M, Hara S, Hosoda K, Ariyoshi K, Li X, Nakagawa H, Ono T, Abe Y
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Journal Title
Proc 35th Ann Intern Conf IEEE EMBS
Pages: 671-674
Peer Reviewed
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[Journal Article] The helical flow pump with a hydrodynamic levitation impeller2012
Author(s)
Abe Y, Ishii K, Isoyama T, Saito I, Inoue Y, Ono T, Nakagawa H, Nakano E, Fukazawa K, Ishihara K, Fukunaga K, Ono M, Imachi K
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Journal Title
J Artif Organs
Volume: 15
Pages: 331-340
DOI
Peer Reviewed
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[Journal Article] Use of in vivo insert molding to form a jellyfish valve leaflet2010
Author(s)
Kishi A, Isoyama T, Saito I, Miura H, Nakagawa H, Kouno A, Ono T, Inoue Y, Yamaguchi S, Wei S, Abe Y, Imachi K, and Noshiro M
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Journal Title
Artif Organs
Volume: 34
Pages: 1125-1131
Peer Reviewed
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