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2013 Fiscal Year Final Research Report

Comprehensive study of an implantable total artificial heart using continuous flow blood pump

Research Project

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Project/Area Number 22249053
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Thoracic surgery
Research InstitutionThe University of Tokyo

Principal Investigator

ABE Yusuke  東京大学, 医学(系)研究科(研究院), 准教授 (90193010)

Co-Investigator(Renkei-kenkyūsha) ONO Minoru  東京大学, 大学院医学系研究科, 教授 (40270871)
ISIYAMA Takashi  東京大学, 大学院医学系研究科, 講師 (20302789)
SAITO Itsuro  東京大学, 大学院医学系研究科, 特任研究員 (80334225)
IMACHI Kou  東京大学, 大学院医学系研究科, 名誉教授 (10010076)
Research Collaborator NAKAGAWA Hidemoto   (40311667)
INOUE Yusuke  東京大学, 大学院工学系研究科, 特任研究員 (80611079)
SHI Wei  サクラ精機株式会社
ISHII Kohei  香川高等専門学校, 機械電子工学科, 助教
中野 英美子  東京医科歯科大学, 医学部付属病院, MEセンター
HOSODA Kyohei  株式会社サンメディカル技術研究所
OHASHI Kouki  日本光電工業株式会社
WU Sheng-yuan  ソフトバンク株式会社
ARIYOSHI Kouki  東京大学, 大学院医学系研究科, 大学院生
HARA Shintaro  東京大学, 大学院医学系研究科, 大学院生
LI Xin-yang  東京大学, 大学院医学系研究科, 大学院生
SATO Masami  東京大学, 大学院医学系研究科, 大学院生
KAWASE Yukino  北里大学, 大学院医療系研究科, 大学院生
YURIMOTO Terumi  東京大学, 大学院医学系研究科, 大学院生
MURAKAMI Haruka  東京大学, 大学院医学系研究科, 大学院生
ONO Toshiya  東京大学, 大学院医学系研究科, 技術専門員
Project Period (FY) 2010-04-01 – 2014-03-31
Keywords完全人工心臓 / 連続流ポンプ / 生理的制御 / 圧センサー / ハイブリッド
Research Abstract

The total artificial heart (TAH) is expected to be an ultimate device for heart replacement. To develop small-size implantable TAH with high performance, improvement of the undulation pump TAH and development of the helical flow TAH (HFTAH) that is a next generation TAH were performed. The newly developed HFTAH was implanted in goats and 100 days of maximum survival was obtained by providing 1/R control that is a physiological control method of the TAH. In the experiment of treadmill exercise with the nonpulsatile TAH, there found no obvious difference between pulsatile and nonpulsatile TAHs. To develop an implantable controller, calibration method of implantable pressure sensor (IPS) and estimation logic of mean atrial pressure using IPS were performed. To improve biological compatibility of device parts, the hybrid parts constructed with fusion of artificial material and biological material were developed.

  • Research Products

    (52 results)

All 2014 2013 2012 2011 2010 Other

All Journal Article (10 results) (of which Peer Reviewed: 10 results) Presentation (41 results) Remarks (1 results)

  • [Journal Article] Computational fluid dynamics analysis of the pump parameters in the helical flow pump2014

    • Author(s)
      Hosoda K, Ishii K, Isoyama T, Saito I, Inoue Y, Ariyoshi K, Ono T, Nakagawa H, Imachi K, Kumagai H, Abe Y
    • Journal Title

      J Artif Organs

      Volume: 17 Pages: 9-15

    • DOI

      10.1007/s10047-013-0739-8

    • Peer Reviewed
  • [Journal Article] The helical flow total artificial heart : implantation in goats2013

    • Author(s)
      Abe Y, Ishii K, Isoyama T, Saito I, Inoue Y, Sato M, Hara S, Hosoda K, Ariyoshi K, Nakagawa H, Ono T, Fukazawa K, Ishihara K, Imachi K
    • Journal Title

      Proc 35th Ann Intern Conf IEEE EMBS

      Pages: 2720-2723

    • Peer Reviewed
  • [Journal Article] Pulsatile driving of the helical flow pump2013

    • Author(s)
      Ishii K, Hosoda K, Isoyama T, Saito I, Ariyoshi K, Inoue Y, Sato M, Hara S, lee X, Wu S, Ono T, Nakagawa H, Imachi K, Abe Y
    • Journal Title

      Proc 35th Ann Intern Conf IEEE EMBS

      Pages: 2724-2727

    • Peer Reviewed
  • [Journal Article] Relation between left atrial pressure and the corresponding pulse pressure in the helical flow total artificial heart2013

    • Author(s)
      Wu S-Y, Saito I, Isoyama T, Inoue Y, Ishii K, Sato M, Hara S, Hosoda K, Ariyoshi K, Li X, Nakagawa H, Ono T, Abe Y
    • Journal Title

      Proc 35th Ann Intern Conf IEEE EMBS

      Pages: 671-674

    • Peer Reviewed
  • [Journal Article] The helical flow pump with a hydrodynamic levitation impeller2012

    • Author(s)
      Abe Y, Ishii K, Isoyama T, Saito I, Inoue Y, Ono T, Nakagawa H, Nakano E, Fukazawa K, Ishihara K, Fukunaga K, Ono M, Imachi K
    • Journal Title

      J Artif Organs

      Volume: 15 Pages: 331-340

    • DOI

      10.1007/s10047-012-0659-z

    • Peer Reviewed
  • [Journal Article] Development of normal-suction boundary control method based on inflow cannula pressure waveform for the undulation pump ventricular assist device2012

    • Author(s)
      Ishii K, Saito I, Isoyama T, Nakagawa H, Nakano E, Ono T, Shi W, Inoue Y, Abe Y
    • Journal Title

      Artif Organs

      Volume: 36 Pages: 812-816

    • DOI

      10.1111/j.1525-1594.2012.01451.x

    • Peer Reviewed
  • [Journal Article] Results of animal experiments with the fourth model of the undulation pump total artificial heart in goat2011

    • Author(s)
      Abe Y, Isoyama T, Saito I, Shi W, Inoue Y, Ishii K, Nakagawa H, Ono T, Ono M, Imachi K
    • Journal Title

      Artif Organs

      Volume: 35 Pages: 781-790

    • DOI

      10.1111/j.1525-1594.2011.01318.x

    • Peer Reviewed
  • [Journal Article] Automatic calibration of the inlet pressure sensor for the implantable continuous-flow ventricular assist device2011

    • Author(s)
      Shi W, Saito I, Isoyama T, Nakagawa H, Inoue Y, Ono T, Kouno A, Imachi K, Abe Y
    • Journal Title

      J Artif Organs

      Volume: 14 Pages: 81-88

    • DOI

      10.1007/s10047-011-0556-x

    • Peer Reviewed
  • [Journal Article] Use of in vivo insert molding to form a jellyfish valve leaflet2010

    • Author(s)
      Kishi A, Isoyama T, Saito I, Miura H, Nakagawa H, Kouno A, Ono T, Inoue Y, Yamaguchi S, Wei S, Abe Y, Imachi K, and Noshiro M
    • Journal Title

      Artif Organs

      Volume: 34 Pages: 1125-1131

    • Peer Reviewed
  • [Journal Article] Preliminary study of physiological control for the undulation pump ventricular assist device2010

    • Author(s)
      Saito I, Ishii K, Isoyama T, Ono T, Nakagawa H, Shi W, Inoue Y, Abe Y
    • Journal Title

      Proc 32th Ann Intern Conf IEEE EMBS

      Pages: 5218-5221

    • Peer Reviewed
  • [Presentation] Total artificial heart : what we need?2013

    • Author(s)
      Yusuke Abe
    • Organizer
      JSAO & IFAO Joint Congress 2013
    • Place of Presentation
      Pacifico Yokohama, Yokohama
    • Year and Date
      2013-09-29
  • [Presentation] Importance of inlet pressure monitoring and pulsatility for RBP2013

    • Author(s)
      Takashi Isoyama
    • Organizer
      JSAO & IFAO Joint Congress 2013
    • Place of Presentation
      Pacifico Yokohama, Yokohama
    • Year and Date
      2013-09-28
  • [Presentation] The Nonlinearity of Left Atrium Volume-Pressure Relationship and the Applicability in the Pressure Sensor Calibration of Helical Flow Total Artificial Heart (HFTAH)2013

    • Author(s)
      Sheng-Yuan Wu
    • Organizer
      JSAO & IFAO Joint Congress 2013
    • Place of Presentation
      Pacifico Yokohama, Yokohama
    • Year and Date
      2013-09-28
  • [Presentation] Flow rate and pressure head estimation in helical flow pump using the table method2013

    • Author(s)
      Shintaro Hara
    • Organizer
      JSAO & IFAO Joint Congress 2013
    • Place of Presentation
      Pacifico Yokohama, Yokohama
    • Year and Date
      2013-09-28
  • [Presentation] Development of a physiological control method for the helical flow total artificial heart2013

    • Author(s)
      Itsuro Saito
    • Organizer
      JSAO & IFAO Joint Congress 2013
    • Place of Presentation
      Pacifico Yokohama, Yokohama
    • Year and Date
      2013-09-28
  • [Presentation] Hemodynamic characteristics of the herical flow pump2013

    • Author(s)
      Kohei Ishii
    • Organizer
      ISRBP 2013
    • Place of Presentation
      Pacifico Yokohama, Yokohama
    • Year and Date
      2013-09-27
  • [Presentation] Development of hybrid blood inflow cannula using titanium core for ventricular assist device2013

    • Author(s)
      Yukino Kawase
    • Organizer
      IEEE EMBS 2013
    • Place of Presentation
      Osaka International Convention Center, Osaka
    • Year and Date
      2013-07-06
  • [Presentation] Relation between left atrial pressure and the corresponding pulse pressure in the helical flow total artificial heart2013

    • Author(s)
      Sheng-Yuan Wu
    • Organizer
      IEEE EMBS 2013
    • Place of Presentation
      Osaka International Convention Center, Osaka
    • Year and Date
      2013-07-04
  • [Presentation] Pulsatile Driving of the Helical Flow Pump2013

    • Author(s)
      Kohei Ishii
    • Organizer
      IEEE EMBS 2013
    • Place of Presentation
      Osaka International Convention Center, Osaka
    • Year and Date
      2013-07-04
  • [Presentation] The helical flow total artificial heart : implantation in goats2013

    • Author(s)
      Yusuke Abe
    • Organizer
      IEEE EMBS 2013
    • Place of Presentation
      Osaka International Convention Center, Osaka
    • Year and Date
      2013-07-04
  • [Presentation] Troidal Convolution blood Pump for ECLS system2013

    • Author(s)
      Takashi Isoyama
    • Organizer
      ASAIO 59th annual conference
    • Place of Presentation
      Chicago Hilton, Chicago, USA
    • Year and Date
      2013-06-13
  • [Presentation] 螺旋流完全人工心臓におけるテーブル型流量差圧推定モデルの構築2012

    • Author(s)
      原伸太郎
    • Organizer
      第50回日本人工臓器学会大会
    • Place of Presentation
      アクロス福岡、福岡
    • Year and Date
      2012-11-23
  • [Presentation] 螺旋流血液ポンプにおける流路形状と内部流れの関係に関する研究2012

    • Author(s)
      細田享平
    • Organizer
      第50回日本人工臓器学会大会
    • Place of Presentation
      アクロス福岡、福岡
    • Year and Date
      2012-11-23
  • [Presentation] 螺旋流型補助人工心臓用ハイブリッド脱血カニューレの研究2012

    • Author(s)
      井上雄介
    • Organizer
      第50回日本人工臓器学会大会
    • Place of Presentation
      アクロス福岡、福岡
    • Year and Date
      2012-11-23
  • [Presentation] 螺旋流血液ポンプの溶血特性向上に向けた検討2012

    • Author(s)
      石井耕平
    • Organizer
      第50回日本人工臓器学会大会
    • Place of Presentation
      アクロス福岡、福岡
    • Year and Date
      2012-11-23
  • [Presentation] The helical flow pump and the helical flow total artificial heart2012

    • Author(s)
      Yusuke Abe
    • Organizer
      39th Congress of ESAO
    • Place of Presentation
      Academy of Music and Theatre, Rostock, Germany
    • Year and Date
      2012-09-29
  • [Presentation] Development of hybrid inflow cannula for ventricular assist devices2012

    • Author(s)
      Yusuke Inoue
    • Organizer
      39th Congress of ESAO
    • Place of Presentation
      Academy of Music and Theatre, Rostock, Germany
    • Year and Date
      2012-09-28
  • [Presentation] The helical flow total artificial heart : initial results of animal experiment2012

    • Author(s)
      Yusuke Abe
    • Organizer
      ISRBP 2012
    • Place of Presentation
      Grand Cevahir Hotel, Istanbul, Turkey
    • Year and Date
      2012-09-22
  • [Presentation] Development of hybrid inflow cannula for helical flow ventricular assist device2012

    • Author(s)
      Yusuke Inoue
    • Organizer
      ISRBP 2012
    • Place of Presentation
      Grand Cevahir Hotel, Istanbul, Turkey
    • Year and Date
      2012-09-21
  • [Presentation] 数値流体力学解析を用いた螺旋流血液ポンプの性能向上に関する研究2012

    • Author(s)
      細田享平
    • Organizer
      生体医工学シンポジウム2012
    • Place of Presentation
      大阪大学、大阪
    • Year and Date
      2012-09-07
  • [Presentation] The helical flow total artificial heart : design concept and initial development2012

    • Author(s)
      Yusuke Abe
    • Organizer
      ASAIO 58th annual conference
    • Place of Presentation
      Fairmont San Francisco, San Francisco, USA
    • Year and Date
      2012-06-15
  • [Presentation] Hyderodynamic bearing for the helical flow total artificial heart2012

    • Author(s)
      Kohei Ishii
    • Organizer
      ASAIO 58th annual conference
    • Place of Presentation
      Fairmont San Francisco, San Francisco, USA
    • Year and Date
      2012-06-14
  • [Presentation] ハイブリッド型人工材料を用いた補助人工心臓用脱血カニューレの開発2012

    • Author(s)
      井上雄介
    • Organizer
      第51回日本生体医工学会大会
    • Place of Presentation
      福岡国際会議場、福岡
    • Year and Date
      2012-05-11
  • [Presentation] 螺旋流完全人工心臓のための動圧軸受の開発2012

    • Author(s)
      石井耕平
    • Organizer
      第51回日本生体医工学会大会
    • Place of Presentation
      福岡国際会議場、福岡
    • Year and Date
      2012-05-10
  • [Presentation] CFD 解析を用いた螺旋流血液ポンプの最適設計2011

    • Author(s)
      細田享平
    • Organizer
      第49回日本人工臓器学会大会
    • Place of Presentation
      都市センターホテル、東京
    • Year and Date
      2011-11-27
  • [Presentation] 完全人工心臓のためのHelical Flow Pump における拍動性能の評価2011

    • Author(s)
      石井耕平
    • Organizer
      第49回日本人工臓器学会大会
    • Place of Presentation
      都市センターホテル、東京
    • Year and Date
      2011-11-27
  • [Presentation] 波動型完全人工心臓と螺旋流完全人工心臓2011

    • Author(s)
      阿部裕輔
    • Organizer
      第49回日本人工臓器学会大会
    • Place of Presentation
      都市センターホテル、東京
    • Year and Date
      2011-11-27
  • [Presentation] The helical flow pump for the total artificial heart2011

    • Author(s)
      Yusuke Abe
    • Organizer
      ISRBP 2011
    • Place of Presentation
      Louisville Marriott Downtown Convention Hotel, Louisville, USA
    • Year and Date
      2011-09-09
  • [Presentation] Appropriate vane number in a helical flow pump2011

    • Author(s)
      Kohei Ishii
    • Organizer
      ISRBP 2011
    • Place of Presentation
      Louisville Marriott Downtown Convention Hotel, Louisville, USA
    • Year and Date
      2011-09-09
  • [Presentation] Helical Flow Pump(HFP)の拍出性能向上に向けたベーン枚数の検討2011

    • Author(s)
      石井耕平
    • Organizer
      第50回日本生体医工学会大会
    • Place of Presentation
      東京電機大学、東京
    • Year and Date
      2011-05-01
  • [Presentation] 波動型完全人工心臓と螺旋流完全人工心臓2011

    • Author(s)
      阿部裕輔
    • Organizer
      第50回日本生体医工学会大会
    • Place of Presentation
      東京電機大学、東京
    • Year and Date
      2011-05-01
  • [Presentation] 補助人工心臓用ハイブリッド型脱血カニューレの作製‐ハイブリッド材料の脱細胞化‐2011

    • Author(s)
      中野英美子
    • Organizer
      第50回日本生体医工学会大会
    • Place of Presentation
      東京電機大学、東京
    • Year and Date
      2011-04-30
  • [Presentation] 螺旋流血液ポンプにおけるポンプ特性評価と流れの可視化評価2011

    • Author(s)
      有吉洸希
    • Organizer
      第50回日本生体医工学会大会
    • Place of Presentation
      東京電機大学、東京
    • Year and Date
      2011-04-30
  • [Presentation] Preliminary Study of Physiological Control for the Undulation Pump Ventricular Assist Device2010

    • Author(s)
      Itsuro Saito
    • Organizer
      IEEE EMBS 2010
    • Place of Presentation
      Sheraton Buenos Aires Hotel & Convention Center, Buenos Aires, Argentina
    • Year and Date
      20100000
  • [Presentation] 無拍動流完全人工心臓の生理的制御の可能性2010

    • Author(s)
      阿部裕輔
    • Organizer
      第48回日本人工臓器学会大会
    • Place of Presentation
      仙台国際センター、仙台
    • Year and Date
      2010-11-20
  • [Presentation] 波動型完全人工心臓4 次モデルの動物実験結果2010

    • Author(s)
      阿部裕輔
    • Organizer
      第48回日本人工臓器学会大会
    • Place of Presentation
      仙台国際センター、仙台
    • Year and Date
      2010-11-19
  • [Presentation] 埋込型血圧センサーの自動キャリブレーション法の動物実験での検討2010

    • Author(s)
      時偉
    • Organizer
      第48回日本人工臓器学会大会
    • Place of Presentation
      仙台国際センター、仙台
    • Year and Date
      2010-11-18
  • [Presentation] Fourth model of the undulation pump total artificial heart : results of implantation in goat2010

    • Author(s)
      Kou Imachi
    • Organizer
      ISRBP 2010
    • Place of Presentation
      NH Berlin- Mitte, Berlin, Germany
    • Year and Date
      2010-10-16
  • [Presentation] Development of the control method for the UPVAD based on inflow cannula pressure waveform2010

    • Author(s)
      Kohei Ishii
    • Organizer
      ISRBP 2010
    • Place of Presentation
      NH Berlin- Mitte, Berlin, Germany
    • Year and Date
      2010-10-14
  • [Presentation] Study of Hybrid Type Inlet Cannula for Ventricular Assist Device2010

    • Author(s)
      中野英美子
    • Organizer
      第49回日本生体医工学会大会
    • Place of Presentation
      大阪国際交流センター、大阪
    • Year and Date
      2010-06-26
  • [Presentation] Animal experimental results of the undulation pump total artificial heart version 42010

    • Author(s)
      阿部裕輔
    • Organizer
      第49回日本生体医工学会大会
    • Place of Presentation
      大阪国際交流センター、大阪
    • Year and Date
      2010-06-25
  • [Remarks]

    • URL

      http://www.bme.gr.jp/Research_info/AH.html

URL: 

Published: 2015-06-25  

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