2012 Fiscal Year Final Research Report
Development of new strategies to overcome glioblastoma invasiveness and drug-resistance using a glioma stem cell model
| Project/Area Number |
22249055
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Keio University |
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Principal Investigator |
SAYA Hideyuki 慶應義塾大学, 医学部, 教授 (80264282)
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| Co-Investigator(Kenkyū-buntansha) |
SAMPETREAN Oltea 慶應義塾大学, 医学部, 助教 (50571113)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 細胞・組織 / 癌 / 発生・分化 / 遺伝子 / バイオテクノロジー |
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| Research Abstract |
The goal of this study was to identify the molecular basis of the high invasiveness and aggressiveness of malignant gliomas in order to develop novel therapeutic strategies. Using our syngeneic murine model of glioblastoma, we
(1) established an assay for the real-time monitoring of glioma cell invasion into the normal brain and identified the main invasion patterns;
(2) showed that inhibition of mesenchymal characteristics of glioma cells effectively reduces invasion and identified potential targeting agents. Furthermore, we uncovered the co-option of endothelial cells by tumor cells and the formation of invasion com
(3) analyzed the mechanism of aquired radioresistance during repeated radiation and identified one of its key regulators.
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Research Products
(24 results)
