2013 Fiscal Year Final Research Report
Basic and clinical research on recovery of vision by electrical stimulation
| Project/Area Number |
22249058
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (A)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Ophthalmology
|
|---|
| Research Institution | Osaka University |
|---|
Principal Investigator |
FUJIKADO Takashi 大阪大学, 医学(系)研究科(研究院), 教授 (50243233)
|
|---|
| Project Period (FY) |
2010-04-01 – 2013-03-31
|
| Keywords | 神経保護 / 電気刺激 / 人工視覚 / 網膜機能画像 / ラマン分光 |
|---|
| Research Abstract |
IGF1 mRNA was increased by the electrical stimulation on cultured RGC5, which suggests that IGF1 is involved in the neuro-protection mechanism by electrical stimulation (ES). The process of neuronal cell-death was demonstrated sequentially and 2-dimensionally by Raman microscope by probing the intracellular changes of cytochrome C. Trans-corneal electrical stimulation (TES) on rabbit model of retinal degeneration showed a decrease of OPL thickness, which suggests the neuro-protective effect of ES on photoreceptors. Clinical study on the artificial vision by optic nerve stimulation showed the efficacy of ES to elicit phosphine for 2 years for advanced retinitis pigmentosa patients.
|
Research Products
(11 results)
-
-
[Journal Article] Feasibility of 2nd generation STS retinal prosthesis in dogs2013
Author(s)
Fujikado T, Kamei M, Sakaguchi H, Kanda H, Morimoto T, Nishida K, Kishima H, Maruo T, Oosawa K, Ozawa M, Nishida K
-
Journal Title
Conf Proc IEEE Eng Med Biol Soc.
Volume: 2013
Pages: 3119-21
-
-
[Journal Article] Testing of semichronically implanted retinal prosthesis by suprachoroidal-transretinal stimulation in patients with retinitis pigmentosa2011
Author(s)
Fujikado T, Kamei M, Sakaguchi H, Kanda H, Morimoto T, Ikuno Y, Nishida K, Kishima H, Maruo T, Konoma K, Ozawa M, Nishida K
-
Journal Title
Invest Ophthalmol Vis Sci.
Volume: 52
Pages: 4726-33
-
[Journal Article] Chronic implantation of newly developed suprachoroidal- transretinal stimulation (STS) prosthesis in dogs2011
Author(s)
Morimoto T, Kamei M, Nishida K, Sakaguchi H, Kanda H, Ikuno Y, Kishima H, Maruo T, Konoma K, Ozawa M, Nishida K, Fujikado T
-
Journal Title
Invest Ophthalmol Vis Sci.
Volume: 52
Pages: 6785-92
-
-
-
-
-
-
