2013 Fiscal Year Final Research Report
The technological development of bioengineered regenerated tooth, based on the mechanism of development
| Project/Area Number |
22249064
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Prosthetic dentistry
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| Research Institution | Okayama University |
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Principal Investigator |
KUBOKI Takuo 岡山大学, 医歯(薬)学総合研究科, 教授 (00225195)
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| Co-Investigator(Kenkyū-buntansha) |
TAKIGAWA Masaharu 岡山大学, 医歯薬学総合研究科, 教授 (20112063)
SONOYAMA Wataru 岡山大学, 大学病院, 講師 (40325121)
TSUJI Takashi 東京理科大学, 総合研究機構, 教授 (50339131)
ASAHARA Hiroshi 東京医科歯科大学, 医歯薬学総合研究科, 教授 (70294460)
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| Project Period (FY) |
2010-04-01 – 2014-03-31
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| Keywords | 再生歯 |
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| Research Abstract |
In the dental field, the regeneration of complete tooth is ultimate goal. First, we examined whether fully functional bioengineered tooth could regenerate utilizing an organ germ method with the permanent tooth bud tissue of the post-natal canine, we succeeded in it, for the first time in the world. Next, in order to understand the mechanism of tooth development, we performed the screening and clarified that several Hox gene specifically expressed in the development of tooth.
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[Journal Article] Novel chondrogenic and chondroprotec- tive effects of the natural compound harmine2013
Author(s)
Hara ES, Ono M, Kubota S, SonoyamaW, Oida Y, Hattori T, Nishida T, Furumatsu T, Ozaki T, Takigawa M, Kuboki T
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Journal Title
Biochimie
Volume: 95(2)
Pages: 374-381
Peer Reviewed
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[Journal Article] Functional lacrimal gland regeneration by transplantation of a bioengineered organ germ2013
Author(s)
Hirayama M, Ogawa M, Oshima M, Sekine Y, Ishida K, Yamashita K, Ikeda K, Shimmura S, Kawakita T, Tsubota K, and Tsuji T
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Journal Title
Nature Communications
Volume: 4
Pages: 2497
Peer Reviewed
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[Journal Article] MAML1 enhances the transcriptional activity of Runx2 and plays a role in bone development2013
Author(s)
Watanabe T, Oyama T, Asada M, Harada D, Ito Y, InagawaM, Suzuki Y, Sugano S, Katsube K, Karsenty G, Komori T, Kitagawa M, Asahara H
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Journal Title
PLoS Genetics
Volume: 9(1)
Pages: e1003132
Peer Reviewed
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[Journal Article] Stage-specific embryonic antigen-4 identifies human dental pulp stem cells2012
Author(s)
Kawanabe N, Murata S, Fukushima H, Ishihara Y, Yanagita T, Yanagita E, Ono M, Kurosaka H, Kamioka H, Itoh T, Kuboki T, and Yamashiro T
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Journal Title
Experimental Cell Research
Volume: 318(5)
Pages: 453-463
Peer Reviewed
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[Journal Article] Hair organ regeneration via the bioengineered hair follicular unit transplantation2012
Author(s)
Asakawa K, Toyoshima K, Ishibashi N, Tobe H, Iwadate A, Kanayama T, Hasegawa T, Nakao K, Toki H, Noguchi S, Ogawa M, Sato A, and Tsuji T
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Journal Title
Scientific Reports
Volume: 2(424)
DOI
Peer Reviewed
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[Journal Article] Fully functional hair follicle regeneration through the rearrangement of stem cells and their niches2012
Author(s)
Toyoshima K, Asakawa K, Ishibashi N, Toki H, Ogawa M, Hasegawa T, Irie T, Tachikawa T, Sato A, Takeda A, and Tsuji T
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Journal Title
Nature Communications
Volume: 3(784)
DOI
Peer Reviewed
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[Journal Article] Functional tooth regeneration using a bioengineered tooth unit as a mature organ replacement regenerative therapy2011
Author(s)
Oshima M, Mizuno M, Imamura A, Ogawa M, Yasukawa M, Yamazaki H, Morita R, Ikeda E, Nakao K, Yamamoto TT, Kasugai S, Saito M and Tsuji T
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Journal Title
PLoS ONE
Volume: 6(7)
Pages: e21531
Peer Reviewed
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[Journal Article] The Mohawk homeobox gene is a critical regulator of ten don differentiation2010
Author(s)
Ito Y, Toriuchi N, Yoshitaka T, Ueno-Kudoh H, Sato T, Yokoyama S, Nishida K, Akimoto T, Takahashi M, Miyaki S, Asahara H
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Journal Title
Proc Natl Acad Sci USA
Volume: 107(23)
Pages: 10538-10542
Peer Reviewed
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