2012 Fiscal Year Final Research Report
Biological design principle-based synthetic biology
| Project/Area Number |
22300101
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bioinformatics/Life informatics
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| Research Institution | Kyushu Institute of Technology |
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Principal Investigator |
KURATA Hiroyuki 九州工業大学, 情報工学研究院, 教授 (90251371)
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| Co-Investigator(Renkei-kenkyūsha) |
SHIMIZU Kazuyuki 九州工業大学, 情報工学研究院, 教授 (00150318)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 生体生命システム情報学 |
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| Research Abstract |
We define bioalgorithms as the step-by-step molecular process of how the biochemical networks including elementary networks and network motifs generate their particular functions, that is to say, the network-function relationships (NFR). The bioalgorithms would be invaluable for synthetic biology, providing an instruction for how we engineer robust biological circuits that carry out a target function. In this study, based on the bioalgorithms, we combined subnetworks of glycolysis, TCA cycle, pentose phosphate pathway, and the anapleorotic pathways to present a dynamic model of the E. call central metabolic network. Our model reproduced the changing patterns of extracellular and intracellular metabolite concentrations in the batch and continuous cultivations.
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