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2012 Fiscal Year Final Research Report

Development and application of photonic DNA processor

Research Project

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Project/Area Number 22300103
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Bioinformatics/Life informatics
Research InstitutionOsaka University

Principal Investigator

TANIDA Jun  大阪大学, 大学院・情報科学研究科, 教授 (00183070)

Co-Investigator(Kenkyū-buntansha) OGURA Yusuke  大阪大学, 大学院・情報科学研究科, 准教授 (20346191)
YAMADA Kenji  大阪大学, 大学院・医学系研究科, 特任教授 (70364114)
Co-Investigator(Renkei-kenkyūsha) YAMAMOTO Hirotsugu  徳島大学, 工学部, 講師 (00284315)
KAGAWA Keiichiro  静岡大学, 電子工学研究所, 特任准教授 (30335484)
Project Period (FY) 2010 – 2012
KeywordsフォトニックDNAプロセッサ / DNAコンピュータ / 分子センサ / 生体生命情報学 / ナノマシン / 情報システム / 蛍光 / 光マニピュレーション
Research Abstract

This study was aimed at developing a photonic DNA processor, which is a nanoscale processor with sensing and actuating functionalities. We built a prototype equipped with a molecular sensor that can be activated/inactivated via external light signals, and demonstrated the fundamental functions. DNA scaffold logic was proposed to extend the processor's function. We constructed a method for logic operations by optical manipulation of liquid-based microreactors. A potential applicability to molecular image memory was shown.

  • Research Products

    (31 results)

All 2013 2012 2011 2010

All Journal Article (10 results) (of which Peer Reviewed: 8 results) Presentation (21 results)

  • [Journal Article] A nanoscale set-reset flip-flop in fluorescence resonance energy transfer-based circuits2013

    • Author(s)
      T. Nishimura, Y. Ogura, and J. Tanida
    • Journal Title

      Applied Physics Express

      Volume: Vol.6 Pages: 015201

    • DOI

      DOI:10.7567/APEX.6.015201

    • Peer Reviewed
  • [Journal Article] Fluorescence resonance energy transfer-based molecular logic circuit using a DNA scaffold2012

    • Author(s)
      T. Nishimura, Y. Ogura, and J. Tanida
    • Journal Title

      Applied Physics Letters

      Volume: Vol.101 Pages: 233703

    • DOI

      DOI:10.1063/1.4769812

    • Peer Reviewed
  • [Journal Article] Reusable molecular sensor based on photonic activation control of DNA probes2012

    • Author(s)
      T. Nishimura, Y. Ogura, and J. Tanida
    • Journal Title

      Biomedical Optics Express

      Volume: Vol.3 Pages: 920-926

    • DOI

      DOI:10.1364/BOE.3.000920

    • Peer Reviewed
  • [Journal Article] フォトニックDNAナノマシン2012

    • Author(s)
      小倉裕介, 西村隆宏, 谷田 純
    • Journal Title

      光 学

      Volume: Vol. 41 Pages: 90-92

  • [Journal Article] Optofluidic DNA computation based on optically manipulated microdroplets2012

    • Author(s)
      T. Nishimura, Y. Ogura, J. Tanida
    • Journal Title

      Microfluidics and Nanofluidics

      Volume: Vol. 13 Pages: 1-7

    • DOI

      DOI:10.1007/s10404-012-0934-6

    • Peer Reviewed
  • [Journal Article] Photonic nanoscale automaton based on photo-/heat-regulated DNA displacement reactions2012

    • Author(s)
      H. Sakai, Y. Ogura J. Tanida
    • Journal Title

      International Journal of Unconventional Computing

      Volume: Vol. 8 Pages: 207-220

    • Peer Reviewed
  • [Journal Article] Large-area manipulation of microdroplets by holographic optical tweezers based on a hybrid diffractive system2011

    • Author(s)
      Y. Ogura, Y. Kazayama, T. Nishimura, J. Tanida
    • Journal Title

      Applied Optics

      Volume: Vol.50 Pages: H36-H41

    • DOI

      DOI:10.1364/AO.50.000H36

    • Peer Reviewed
  • [Journal Article] Spatially parallel control of DNA reactions in optically manipulated micro-droplets2011

    • Author(s)
      Y. Ogura, T. Nishimura and J. Tanida
    • Journal Title

      Journal of Nanophotonics

      Volume: Vol. 5 Pages: 051702

    • DOI

      DOI:10.1117/1.3574171

    • Peer Reviewed
  • [Journal Article] 液晶パネルを用いたセキュアディスプレイ2010

    • Author(s)
      山本裕紹
    • Journal Title

      液晶

      Volume: Vol. 14 Pages: 255-262

    • Peer Reviewed
  • [Journal Article] バイオインスパイヤードフォトニック情報技術2010

    • Author(s)
      谷田 純
    • Journal Title

      化学工業

      Volume: Vol. 61 Pages: 786-791

  • [Presentation] 光活性型蛍光分子を用いた光入力型フリップフロップ2013

    • Author(s)
      西村隆宏, 小倉裕介, 山田憲嗣, 山本裕紹, 谷田純
    • Organizer
      第60回応用物理学会春季学術講演会
    • Place of Presentation
      神奈川工科大学
    • Year and Date
      2013-03-29
  • [Presentation] Photonic Nanoscale Logic Using Fluorescence Resonance Energy Transfer on a DNA Scaffold2012

    • Author(s)
      Yusuke Ogura, Takahiro Nishimura, Hirotsugu Yamamoto, Kenji Yamada, Jun Tanida
    • Organizer
      in The Second Japan-Korea Workshop on Digital Holography and Information Photonics 2012
    • Place of Presentation
      Tokushima, Japan
    • Year and Date
      2012-11-19
  • [Presentation] Computational multiplex imaging2012

    • Author(s)
      Jun Tanida
    • Organizer
      in The Second Japan-Korea Workshop on Digital Holography and Information Photonics 2012
    • Place of Presentation
      Tokushima, Japan
    • Year and Date
      2012-11-19
  • [Presentation] Hand-waving steganography by use of a high-speed LED display2012

    • Author(s)
      Hirotsugu Yamamoto, Syahmi Farhan, Kengo Sato, Shiro Suyama
    • Organizer
      in The Second Japan-Korea Workshop on Digital Holography and Information Photonics
    • Place of Presentation
      Tokushima, Japan
    • Year and Date
      2012-11-19
  • [Presentation] DNA scaffold logic: logic operation on molecular inputs using FRET cascades2012

    • Author(s)
      西村隆宏, 小倉裕介, 山田憲嗣, 山本裕紹, 谷田純
    • Organizer
      第50回日本生物物理学会年会
    • Place of Presentation
      名古屋大学
    • Year and Date
      2012-09-22
  • [Presentation] Functional molecular sensing using photonic DNA nano-processor2012

    • Author(s)
      Yusuke Ogura, Takahiro Nishimura, Hirotsugu Yamamoto, Kenji Yamada, Jun Tanida
    • Organizer
      in 1st International Workshop on Information Physics and Computing in Nano-scale Photonics and Materials
    • Place of Presentation
      Orleans, France
    • Year and Date
      2012-09-07
  • [Presentation] Smart fold computing - A distributed approach to overcome diffraction limit of light2012

    • Author(s)
      Jun Tanida
    • Organizer
      in 1st International Workshop on Information Physics and Computing in Nano-scale Photonics and Materials
    • Place of Presentation
      Orleans, France
    • Year and Date
      2012-09-07
  • [Presentation] DNA logic circuit using fluorescence resonance energy transfer for signal cascade2012

    • Author(s)
      T. Nishimura, Y. Ogura, H. Yamamoto, K. Yamamda, and J. Tanida
    • Organizer
      in 18th International Conference on DNA Computing and Molecular programmig
    • Place of Presentation
      Aarhus, Denmark
    • Year and Date
      2012-08-14
  • [Presentation] 蛍光共鳴エネルギー移動を利用した分子入力・光出力論理回路の実装2012

    • Author(s)
      西村隆宏, 小倉裕介, 山田憲嗣, 山本裕紹, 谷田純
    • Organizer
      第59回応用物理学関係連合講演会
    • Place of Presentation
      早稲田大学
    • Year and Date
      2012-03-16
  • [Presentation] 深い被写界深度をもつ光・画像処理融合型複眼内視鏡システム2011

    • Author(s)
      香川景一郎
    • Organizer
      日本光学会年次学術講演会
    • Place of Presentation
      大阪大学
    • Year and Date
      2011-11-30
  • [Presentation] 蛍光共鳴エネルギー移動を利用したスキャフォールドDNA 論理演算2011

    • Author(s)
      西村隆宏, 小倉裕介, 山田憲嗣, 山本裕紹, 谷田 純
    • Organizer
      日本光学会年次学術講演会Optics & Photonics Japan 2011
    • Place of Presentation
      大阪大学
    • Year and Date
      2011-11-29
  • [Presentation] 光とDNAの協調によるナノ情報処理2011

    • Author(s)
      小倉裕介, 西村隆宏, 酒井寛人, 山本裕紹, 山田憲嗣, 谷田 純
    • Organizer
      日本光学会年次学術講演会 Optics & Photonics Japan 2011
    • Place of Presentation
      大阪大学
    • Year and Date
      2011-11-29
  • [Presentation] Secure Display by Use of Multiple Decoding Masks Based on Visual Cryptography2011

    • Author(s)
      H. Yamamoto, Shiro Suyama
    • Organizer
      in 2011 IEEE Industry Applications Society Annual Meeting
    • Place of Presentation
      Orlando, USA
    • Year and Date
      2011-10-10
  • [Presentation] Bio-molecular sensing by use of DNA that can be activated and reset via photonic signals2011

    • Author(s)
      西村隆宏, 小倉裕介, 山本裕紹, 山田憲嗣, 谷田純
    • Organizer
      第49回日本生物物理学会年会
    • Place of Presentation
      兵庫県立大学
    • Year and Date
      2011-09-21
  • [Presentation] A photonic DNA processor: concept and implementation2011

    • Author(s)
      T. Nishimura, Y. Ogura, K. Yamada, H. Yamamoto, J. Tanida
    • Organizer
      SPIE Optics & Photonics 2011
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2011-08-23
  • [Presentation] Prototype demonstration of a photonic DNA processor: a photonically-controlled DNA nanomachine of sensing, computing, and actuating2011

    • Author(s)
      T. Nishimura, Y. Ogura, K. Yamda, H. Yamamoto, J. Tanida
    • Organizer
      in 7th Annual Conference on Foundations of Nanoscience
    • Place of Presentation
      Snowbird, USA
    • Year and Date
      2011-04-14
  • [Presentation] フォトニック DNA プロセッサプロトタイプの開発2011

    • Author(s)
      西村 隆宏,小倉 裕介,山田 憲嗣,山本 裕紹,谷田 純
    • Organizer
      第58回応用物理学関係連合講演会
    • Place of Presentation
      神奈川工科大学
    • Year and Date
      2011-03-27
  • [Presentation] 分子センサ機能を有する光制御型DNAナノマシン2010

    • Author(s)
      西村 隆宏,小倉 裕介,山田 憲嗣,山本 裕紹,谷田 純
    • Organizer
      日本光学会年次学術講演会 Optics & Photonics Japan 2010
    • Place of Presentation
      中央大学
    • Year and Date
      2010-11-10
  • [Presentation] Nanoscale logic operation in optically manipulated micro-droplets2010

    • Author(s)
      Y. Ogura, T. Nishimura, and J. Tanida
    • Organizer
      in SPIE Optics & Photonics 2010
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2010-08-03
  • [Presentation] Photonic techniques for DNA manipulation toward nanoscale information processing2010

    • Author(s)
      J. Tanida
    • Organizer
      in Workshop on DNA Nanotechnology toward Molecular Robotics
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2010-06-21
  • [Presentation] Operation of DNA Logic Gates by Optical Manipulation of DNA Microdroplets2010

    • Author(s)
      T. Nishimura, Y. Ogura, J. Tanida
    • Organizer
      in The 7th International Conference on Optics-photonics Design and Fabrication
    • Place of Presentation
      Yokohama, Japan
    • Year and Date
      2010-04-19

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Published: 2014-08-29  

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