2012 Fiscal Year Final Research Report
Elucidation of mechanisms of recognizing other's intention using newly developing in vivo connection imaging and electrophyisiology
| Project/Area Number |
22300104
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Neuroscience in general
|
|---|
| Research Institution | National Center of Neurology and Psychiatry |
|---|
Principal Investigator |
NORITAKA Ichinohe 独立行政法人国立精神・神経医療研究センター, 神経研究所 微細構造研究部, 部長 (00250598)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Research Abstract |
We investigated circuits for object recognition in macaque anterior (TE) and posterior inferotemporal cortex (TEO), using a two-step method with in vivo anatomical imaging. In step 1, red fluorescent tracer was injected into TE to reveal and Pre-target patches of feedforward neurons in TEO. In step 2, these were visualized on the cortical surface in vivo, and injected with green fluorescent tracer. Histological processing revealed that patches >500 μm from the injection site in TEO consisted of intermingled green TEO intrinsically projecting neurons and red TEO-to-TE neurons, with only few double-labeled neurons. In contrast, patches near the injection site in TEO contained many double-labeled neurons. Two parallel, spatially intermingled circuits are suggested: (1) TEO neurons having very local intrinsic collaterals and projection to TE (2) TEO neurons projecting more widely in the intrinsic network, but not to TE. These parallel systems might be specialized for, respectively, fast vs. highly processed signals.
|
