2013 Fiscal Year Final Research Report
Molecular mechanisms for central circadian pacemaker regulations
| Project/Area Number |
22300108
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neuroscience in general
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| Research Institution | University of Toyama |
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Principal Investigator |
IKEDA MASAYUKI 富山大学, 大学院理工学研究部(理学), 准教授 (10288053)
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| Co-Investigator(Kenkyū-buntansha) |
IKEDA Masaaki 埼玉医科大学, 医学部, 教授 (80232198)
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| Project Period (FY) |
2010-04-01 – 2014-03-31
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| Keywords | キイロショウジョウバエ / マウス / バイオイメージング / 体内時計 / 分子細胞神経科学 |
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| Research Abstract |
Daily rhythms in diverse activities are governed by transcriptional/translational feedback loops in clock genes. Also, it has been suggested that the circadian dynamics of intracellular signaling messengers such as Ca2+ may be critical both for the cellular physiological activities and gene transcriptional cycles. Based on these, the present study analyzed the clock gene transcriptional rhythms as well as cytosolic H+/Ca2+ in diverse models including Drosophila endocrine oscillators and SCN progenitor cells. The results demonstrated presence of clock gene oscillations but lack of apparent circadian cytosolic Ca2+ waves in these modes. Thus, the present results demonstrate cell-type specific mechanisms for the circadian rhythm generations.
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