2012 Fiscal Year Final Research Report
Study on molecular mechanism underlying brain region-specific Ass deposition
| Project/Area Number |
22300118
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | National Center for Geriatrics and Gerontology |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KATO Koichi 大学共同利用機関法人自然科学研究機構(岡崎共通研究施設), 岡崎統合バイオサイエンスセンター, 教授 (20211849)
MURAYAMA Shigeo 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 老年病理学研究チーム・神経病理学(ブレインバンク), 部長 (50183653)
MATSUBARA Teruhiko 慶應義塾大学, 理工学部, 講師 (10325251)
YAMAMOTO Naoki 立命館大学, 薬学部, 助教 (90393157)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 神経変性疾患 |
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| Research Abstract |
We demonstrated that brain region-specific deposition of amyloid ss-protein (Ass) exclusively depends on the nature of lipid molecules consisting of the neuronal membrane of the given brain region. We also established a system to explore molecular mechanism underlying interaction between Ass and ganglioside, leading to generation of ganglioside-bound Ass, an endogenous seed for amyloid in AD brains.
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[Journal Article] Lysosomal dysfunction in a mouse model of Sandhoff disease leads to accumulation of ganglioside-bound Ass.2012
Author(s)
Keilani S., Lun Y., Stevens A.C., Williams H.N., Sjoberg E.R., Khanna R., Valenzaro K.J., Checler F., Buxbaum J.D., Yanagisawa K., Lockhart D.J., Wustman B.A. and Gandy S.
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Journal Title
J Neurosci
Volume: 32
Pages: 5223-5236
DOI
Peer Reviewed
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[Journal Article] Hyperpolarization-activated cyclic nucleotide gated channels: a potential molecular link between epileptic seizures and Abeta generation in Alzheimer's disease.2012
Author(s)
Saito Y, Inoue T, Zhu G, Kimura N, Okada M, Nishimura M, Kimura N, Murayama S, Kaneko S, Shigemoto R, Imoto K, Suzuki T.
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Journal Title
Mol Neurodegener
Volume: 7:50
DOI
Peer Reviewed
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[Journal Article] α-Synuclein pathology in the amyotrophic lateral sclerosis/ parkinsonism demntia complex in the Kii Peninsula, Japan.2012
Author(s)
Kokubo Y, Taniguchi A, Hasegawa M, Hayakawa Y, Morimoto S, Yoneda M, Hirokawa Y, Shiraishi T, Saito Y, Murayama S, Kuzuhara S.
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Journal Title
J Neuropath Exp Neurol.
Volume: 71(7)
Pages: 625-30
DOI
Peer Reviewed
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[Journal Article] SOD1 (Copper/Zinc Superoxide Dismutase) deficiency drives amyloid β protein oligomerization and memory loss in mouse model of Alzheimer's disease.2011
Author(s)
Murakami K, Murata N, Noda Y, Tahara S, Kaneko T, Kinoshita N, Hatsuta H, Murayama S, Barnham K.J, Irie K, Shirasawa T, Shimizu T.
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Journal Title
J Biol Chem.
Volume: 286
Pages: 44557-44568
DOI
Peer Reviewed
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[Presentation] FUS-immunopositive Inclusions and Compound Pick Bodies in Two Cases of Frontotemporal Lobar Degeneration with Motor Neuron Disease (FTLDMND).2012
Author(s)
Nakamoto F, Takao M, Ikemura M, Hayashi T, Ito S, Maeda D, SaitoY, Takahashi Y, Hasegawa M, Fukayama M, Tsuji S, Murayama S
Organizer
The 8th International Conference on Frontotemporal Dementias.
Place of Presentation
Manchester, UK
Year and Date
20120905-07
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[Presentation] Japanese Consortium for Research in motor Neuron Disease and Frontotemporal Dementia.2011
Author(s)
Murayama S, Saito Y, Takao M, Hatsuta H, Shimizu J, Kihira T, Kokubo Y, Akiyama H, Suzuki, Hasegawa M.
Organizer
87th Annual Meeting of the American Association of Neuropathologists
Place of Presentation
Seattle, USA.
Year and Date
20110623-26
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