neural representation of action categories and object manipulations

2013 Fiscal Year Final Research Report

• Project/Area Number: 22300124
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neurophysiology and muscle physiology
• Research Institution: Tohoku University
• Principal Investigator: MUSHIAKE Hajime 東北大学, 医学(系)研究科(研究院), 教授 (80219849)
• Project Period (FY): 2010-04-01 – 2014-03-31
• Keywords: 運動野 / 両手動作 / 細胞活動

Research Abstract

The aim of this study is how categorical information of multiple actions or operations in higher-ordered motor areas by recoding neural activities from behaving monkeys, We examined neuronal activity in the supplementary and pre-supplementary motor areas of monkeys to investigate how the nervous system deals with the coding 16 motor sequences resulting from multiple actions involving bilateral use of the arms. We first found in both areas that this behavioral demand resulted in attribute-based representation of individual motor acts, reflecting functional (action) or anatomical (right/left arm) attributes. Actions were frequently represented according to a body-axis centered reference frame (supination or pronation) irrespective of the arm to be used. We propose that the two-dimensional attribute-based sequence representation provides a robust and efficient means of processing multiple behavioral sequences.

Research Products

• [Journal Article] 認知的運動制御システム (2014)
  • Author(s): 虫明 元, 岩田潤一
  • Journal Title: 総合リハビリテーション Volume: 43 Pages: 7-12
  • URL: http://medicalfinder.jp/ejournal/top-03869822-42-1.html?ss=%E8%99%AB%E6%98%8E
• [Journal Article] Goal-oriented (2013)
  • Author(s): Sumito Okuyama, Jun-ichi Iwata, Jun Tanji, and Hajime Mushiake
  • Journal Title: flexible numerical operations by monkeys Animal Cognition Volume: 16(3) Pages: 509-18
  • DOI: 10.1007/s10071-012-0592-9
  • Peer Reviewed
• [Journal Article] Neurons in the cingulate motor area signal context-based and outcome-based selection of volitional action (2013)
  • Author(s): Junichi Iwata, Keisetsu Shima, Jun Tanji, and Hajime Mushiake
  • Journal Title: Experimental Brain Res Volume: 229 Pages: 407-17
  • DOI: 10.1007/s00221-013-3442-3
  • Peer Reviewed
• [Journal Article] Participation of neurons in multiple sectors of medial frontal cortex undergoes dynamic alterations depending on the demand for volitional control of action (2013)
  • Author(s): Yoshiya Matsuzaka, Tetsuya Akiyama, Hajime Mushiake
  • Journal Title: Experimental Brain Res Volume: 229 Pages: 395-405
  • DOI: 10.1007/s00221-013-3454-z
  • Peer Reviewed
• [Journal Article] Two-dimensional representation of action and arm sequences in the pre-supplementary and supplementary motor areas (2013)
  • Author(s): Nakajima, T. ,Hosaka, R. Tsuda, I., Tanji, J. and Mushiake, H
  • Journal Title: J Neurosci Volume: 33 Pages: 15533-15544
  • DOI: 10.1523/JNEUROSCI.0855-13.2013
  • Peer Reviewed
• [Journal Article] Increased firing irregularity as an emergent property of neural-state transition in monkey prefrontal cortex (2013)
  • Author(s): Kazuhiro Sakamoto, Yuichi Katori, Naohiro Saito Shun Yoshida, Kazuyuki Aihara and Hajime Mushiake
  • Journal Title: Plos One Volume: 8(12) Pages: e80906
  • DOI: 10.1371/journal.pone.0080906
  • Peer Reviewed
• [Journal Article] Optogenetically induced Seizure and the Longitudinal Hippocampal Network (2013)
  • Author(s): Shin-ichiro Osawa, Masaki Iwasaki, Ryosuke Hosaka, Yoshiya Matsuzaka, Hiroshi Tomita, Toru Ishizuka, Eriko Sugano,Eiichi Okumura, Hiromu Yawo, Nobukazu Nakasato, Teiji Tominaga, Hajime Mushiake
  • Journal Title: PLos One Volume: 10;8(4) Pages: e60928
  • DOI: 10.1371/journal.pone.0060928
  • Peer Reviewed
• [Journal Article] 行動の計画と前頭前野ダイナミクス (2013)
  • Author(s): 坂本一寛、虫明元
  • Journal Title: 日本神経回路学会誌 Volume: vol. 20 Pages: 37-41
  • URL: https://www.jstage.jst.go.jp/browse/jnns/-char/ja/
• [Journal Article] Neuronal activity in the primate dorsomedial prefrontal cortex contributes to strategic selection of response tactics (2012)
  • Author(s): Matsuzaka Y, Akiyama T, Tanji J, Mushiake H
  • Journal Title: Proc Natl Acad Sci U S A. Volume: 109(12) Pages: 4633-8
  • DOI: 10.1073/pnas.1119971109
  • Peer Reviewed
• [Journal Article] 順序動作課題と割込課題からなる二重課題を制御する神経機構, 英文タイトル : Neuronal Mechanism Controlling a Dual-Task Consisting of a Sequential Motor Task and an Interrupting Task (2011)
  • Author(s): 中島 敏, 宮崎 淳, 嶋 啓節, 虫明元
  • Journal Title: 日本神経回路学会誌 Volume: Vol. 18, No. 3 Pages: 129-134
  • URL: https://www.jstage.jst.go.jp/browse/jnns/-char/ja/
• [Journal Article] Representational Switching by Dynamical Reorganization of Attractor Structure in a Network Model of the Prefrontal Cortex (2011)
  • Author(s): Yuichi Katori, Kazuhiro Sakamoto, Naohiro Saito, Jun Tanji, Hajime Mushiake, Kazuyuki Aihara
  • Journal Title: PLoS Computational Biology Volume: 7(11) Pages: 1-17
  • DOI: 10.1371/journal.pcbi.1002266
  • Peer Reviewed
• [Presentation] Cue-Dependent Modulation of Beta-Synchrony in Primates' Medial Motor Areas (2013)
  • Author(s): Haruka Arisawa, Ryosuke Hosaka, Keisetsu Shima,Toshi Nakajima and Hajime Mushiake
  • Organizer: The 4th International Conference on Cognitive Neurodynamics
  • Place of Presentation: Sigtuna, Sweden
  • Year and Date: 20130623-27
• [Presentation] Laterality of Gamma-Oscillations in Monkey Medial Motor Cortex (2013)
  • Author(s): Ryosuke Hosaka, Toshi Nakajima, Kazuyuki Aihara, Yoko Yamaguchi, and Hajime Mushiake
  • Organizer: The 4th International Conference on Cognitive Neurodynamics
  • Place of Presentation: Sigtuna, Sweden
  • Year and Date: 20130623-27
• [Presentation] Excitation -inhibition balance of prefrontal neurons during the execution of a path-planning task (2013)
  • Author(s): Kazuhiro Sakamoto, Naohiro Saito, Shun Yoshida and Hajime Mushiake
  • Organizer: The 4th International Conference on Cognitive Neurodynamics
  • Place of Presentation: Sigtuna, Sweden
  • Year and Date: 20130623-27
• [Presentation] 補足眼野で生成される予測誤差は探索戸知識利用の切り替えを引き起こす (2013)
  • Author(s): Norihiko Kawaguchi, Kazuhiro Sakamoto, Naohiro Saito, Yoshito Furusawa,Jun Tanji, Masashi Aoki, Hajime Mushiake
  • Organizer: 日本神経科学学会大会 (Neuro2013)
  • Place of Presentation: Kyoto (京都、国立京都国際会館)
  • Year and Date: 20130620-23
• [Presentation] Mental Manipulation of Origami Revealed Functional Involvements of Intraparietal Areas and Premotor Areas (2013)
  • Author(s): Norihiko Kawaguchi, Kazuhiro Sakamoto, Masashi Aoki, Hajime Mushiake
  • Organizer: A fMRI study Neural Oscillation Conference 2013
  • Place of Presentation: Okazaki, Japan
  • Year and Date: 2013-07-18
• [Presentation] Modular representation of multiple motor sequences based on action and effector use in the medial motor areas (2012)
  • Author(s): Toshi Nakajima, Ryosuke Hosaka, Jun Tanji and Hajime Mushiake
  • Organizer: 米国神経科学学会 (Neuroscience 2012)
  • Place of Presentation: New Orleans, USA (ポスター発表, 187.19/PP19)
  • Year and Date: 2012-10-14
• [Presentation] Modulation of LFP beta oscillation while updating motor plan in primate medial motor areas (2012)
  • Author(s): Ryosuke Hosaka, Toshi Nakajima, Kazuyuki Aihara, Yoko Yamaguchi and Hajime Mushiake
  • Organizer: 米国神経科学学会 (Neuroscience 2012)
  • Place of Presentation: New Orleans, USA (ポスター発表, 382.5/YY1)
  • Year and Date: 2012-10-14
• [Presentation] エンコード・実行時で異なるニューロン群が反応タクティクスとアクションをコードする, Separate population of prefrontal neurons represent forthcoming tactics and action at the time of encoding and execution (2012)
  • Author(s): 松坂 義哉, 斎藤 雄太郎, 虫明 元
  • Organizer: 日本神経科学会
  • Place of Presentation: 名古屋
  • Year and Date: 2012-09-18
• [Presentation] 経路探索課題中の前頭前野興奮性-抑制性バランスの時間発展, Time-development of excitation-inhibition balance in the prefrontal cortex during a path-planning task (2012)
  • Author(s): 坂本 一寛, 斎藤 尚宏, 吉田 隼, 香取 勇一, 丹治 順, 合原 一幸, 虫明 元
  • Organizer: 日本神経科学会
  • Place of Presentation: 名古屋
  • Year and Date: 2012-09-18
• [Presentation] 視覚探索課題中の行動評価における補足眼野の役割, The role of the supplementary eye field in evaluating outcomes during an oculomotor search task (2012)
  • Author(s): 川口 典彦, 坂本 一寛, 古沢 義人, 丹治順, 青木 正志, 虫明 元
  • Organizer: 日本神経科学会
  • Place of Presentation: 名古屋
  • Year and Date: 2012-09-18
• [Presentation] Is advance planning of sequential movements reflected in the behavior of monkeys? (2012)
  • Author(s): Sakamoto K, Kawaguchi N, Mushaike H
  • Organizer: The 22th Annual Conference of the Japanese Neural Network Society, 日本神経回路学会
  • Place of Presentation: 名古屋
  • Year and Date: 2012-09-13
• [Presentation] Dynamical reorganization of attractor structure in neural network model with dynamic synapses (2012)
  • Author(s): Katori Y, Sakamoto K, Mushiake H, Aihara K
  • Organizer: The 22th Annual Conference of the Japanese Neural Network Society, 日本神経回路学会
  • Place of Presentation: 名古屋
  • Year and Date: 2012-09-12
• [Presentation] 動作順序を事前に決めているか : 形操作課題のサル行動解析 (2012)
  • Author(s): 坂本一寛, 川口 典彦, 虫明 元
  • Organizer: 2012年度 包括脳ネットワーク夏のワークショップ
  • Place of Presentation: 名古屋
  • Year and Date: 2012-07-26
• [Presentation] reciprocal activation of beta and gamma oscillations in primate medial motora areas (2012)
  • Author(s): 保坂亮介, 中島敏, 虫明 元
  • Organizer: 2012年度包括脳ネットワーク夏のワークショップ
  • Place of Presentation: 名古屋
  • Year and Date: 2012-07-26
• [Presentation] 動的システム脳科学の観点から-脳と心を結ぶ理論- (2011)
  • Author(s): 虫明 元
  • Organizer: 文科省数理連携ワークショップ「数理連携10の根本問題の発掘」
  • Place of Presentation: 理化学研究所大河内記念ホール
  • Year and Date: 20111226-29
• [Presentation] Roles of the medial frontal cortices in the selection, storage and retrieval of response tactics in a voluntary arm-reaching task (2011)
  • Author(s): Yoshiya Matsuzaka, Yuutaro Saito, Jun Tanji, Hajime Mushiake
  • Organizer: 第34回神経科学会横浜
  • Place of Presentation: Yokohama JAPAN
  • Year and Date: 20111226-29
• [Presentation] Dynamic neuronal representation in the prefrontal cortex (2011)
  • Author(s): Hajime Mushiake, Keisetsu Shima, Kazuhiro Sakamoto, Yuichi Katori and Kazuyuki Aihara
  • Organizer: The 3rd International Conference on Cognitive Neurodynamics ICCN2011
  • Place of Presentation: Hokaido, Japan
  • Year and Date: 20110609-13
• [Presentation] Dynamic information processing in the supplementary eye field of monkeys during hypothesis testing behavior (2011)
  • Author(s): Norihiko Kawaguchi, Kazuhiro Sakamoto, Yoshito Furusawa, Naohiro Saito, Jun Tanji and Hajime Mushiake
  • Organizer: The 3rd International Conference on Cognitive Neurodynamics ICCN2011
  • Place of Presentation: Hokaido, Japan
  • Year and Date: 20110609-13
• [Presentation] Plan to execution through neuronal synchrony in the prefrontal cortex (2011)
  • Author(s): Kazuhiro Sakamoto, Katsutoshi Yamamoto, Naohiro Saito, Jun Tanji and Hajime Mushiake
  • Organizer: The 3rd International Conference on Cognitive Neurodynamics ICCN2011
  • Place of Presentation: Hokaido, Japan
  • Year and Date: 20110609-13
• [Presentation] Neuronal activity in the prefrontal cortex during performance of a dual task consisting of a main- and an interrupting-task (2011)
  • Author(s): Atsushi Miyazaki, Toshi Nakajima, Keisetsu Shima and Hajime Mushiake
  • Organizer: The 3rd International Conference on Cognitive Neurodynamics ICCN2011
  • Place of Presentation: Hokaido, Japan
  • Year and Date: 20110609-13
• [Presentation] The effect of interrupting a memory-guided sequential motor task on neuronal activity in the dorsal premotor area (2011)
  • Author(s): Atsushi Miyazaki, Toshi Nakajima, Keisetsu Shima, Hajime Mushiake
  • Organizer: 第34回神経科学会横浜
  • Place of Presentation: Yokohama JAPAN
  • Year and Date: 2011-09-17
• [Presentation] Dynamic neural representation in the dorsal premotor cortex during numerical operations (2011)
  • Author(s): Sumito Okuyama, jun-ichi Iwata, Toshinobu Kuki, Jun Tanji, Hajime Mushiake
  • Organizer: 第34回神経科学会横浜
  • Place of Presentation: Yokohama JAPAN
  • Year and Date: 2011-09-17
• [Presentation] A new approach to the study of dynamics of neuronal circuits - Optically induced perturbation method- (2011)
  • Author(s): Hajime Mushiake
  • Organizer: 第34回神経科学会横浜
  • Place of Presentation: Yokohama JAPAN
  • Year and Date: 2011-09-16
• [Presentation] Neuronal activity in the dorsal premotor cortex during a path-planning task (2011)
  • Author(s): Masaya Toyoshima, Yusuke Shibata, Kazuhiro Sakamoto, Naohiro Saito, Jun Tanji, Hajime Mushiake
  • Organizer: 第34回神経科学会横浜
  • Place of Presentation: Yokohama JAPAN
  • Year and Date: 2011-09-16
• [Presentation] Recent progress in studies of the functions of medial frontal cortex (2011)
  • Author(s): Hajime Mushiake, Yoshiya Matsuzaka, Toshi Nakajima and Jun Tanji
  • Organizer: Tohoku International Symposium on Multidisciplinary Neuroscience
  • Place of Presentation: Sendai
  • Year and Date: 2011-01-15
• [Presentation] Supervisory role of the primate medial prefrontal cortex in the selection of response tactics (2011)
  • Author(s): Yoshiya Matsuzaka, Jun Tanji, Hajime Mushiake
  • Organizer: Tohoku International Symposium on Multidisciplinary Neuroscience
  • Place of Presentation: Sendai
  • Year and Date: 2011-01-15
• [Presentation] Neuronal activity in the medial motor areas reflects the sequencing of arm use and action in parallel during performance of a bimanual sequential motor task (2011)
  • Author(s): Toshi Nakajima, Ryosuke Hosaka, Hajime Mushiake, Jun Tanji
  • Organizer: Tohoku International Symposium on Multi-disciplinary Neuroscience
  • Place of Presentation: Sendai
  • Year and Date: 2011-01-15
• [Remarks]
  • URL: http://www.neurophysiology.med.tohoku.ac.jp/