2012 Fiscal Year Final Research Report
Study of molecular mechanisms of germline mutation by using DNA repair deficient mice
| Project/Area Number |
22300144
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory animal science
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| Research Institution | Kyushu University |
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Principal Investigator |
OHNO Mixuki 九州大学, 医学研究院, 助教 (70380524)
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| Co-Investigator(Kenkyū-buntansha) |
TSUZUKI Teruhisa 九州大学, 大学院・医学研究院, 基礎放射線医学分野 (40155429)
NAKATSU Yoshimichi 九州大学, 大学院・医学研究院, 基礎放射線医学分野 (00207820)
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| Project Period (FY) |
2010 – 2012
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| Keywords | DNA修復 / グノム変異 / 継世代影響 / 遺伝子改変マウス / DNA損傷 |
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| Research Abstract |
We established an "oxidative DNA damage repair deficient inbred mouse line", which is useful for the efficient detection and analysis of de novo germline mutation. We showed the 8-oxoguanine is a major source of de novo germline G to T transversion mutati
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Research Products
(16 results)
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[Journal Article] Oxidative stress-induced tumorigenesis in the small intestine of various types of DNA repair-deficient mice (Note).2011
Author(s)
Tsuzuki, T., Piao, J., Isoda, T., Sakumi, K., Nakabeppu, Y., Nakatsu. Y.
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Journal Title
Health Physics
Volume: 100
Pages: 293-294
Peer Reviewed
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