2012 Fiscal Year Final Research Report
Study on enhancement of transdermal vaccination by photothermaleffect
| Project/Area Number |
22300158
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Biomedical engineering/Biological material science
|
|---|
| Research Institution | Kumamoto University (2012)
Kyushu University (2010-2011) |
|---|
Principal Investigator |
NIIDOME Takuro 熊本大学, 大学院・自然科学研究科, 教授 (20264210)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
GOTO Masahiro 九州大学, 大学院・工学研究院, 教授 (10211921)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Keywords | 生体制御 / 治療 / 薬物送達システム |
|---|
| Research Abstract |
Stratum corneum is major barrier of transdermal protein delivery. We tried enhancingpermeability of stratum corneum by photothermal effect of gold nanorods. Ovalbumin wasmixed with gold nanorods, then, applied on skin. After irradiation of near infrared light,translocation of ovalbumin into skin and production of anti-ovalbumin antibody wereobserved. When a pulsed-laser was used, protein translocation without heating deeper partof skin was detected. These data would be important for development of dermal vaccinationsystem.
|
