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2012 Fiscal Year Final Research Report

Mitochondria Treatment by Antioxidant with Multi-enzyme Activity

Research Project

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Project/Area Number 22300166
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Biomedical engineering/Biological material science
Research InstitutionTokyo Metropolitan University

Principal Investigator

KAWAKAMI Hiroyoshi  首都大学東京, 都市環境科学研究科, 教授 (10221897)

Co-Investigator(Kenkyū-buntansha) ASAYAMA Shoichiro  首都大学東京, 都市環境科学研究科, 准教授 (90315755)
SHIMIZU Takahiko  千葉大学, 医学研究科, 客員准教授 (40301791)
Project Period (FY) 2010 – 2012
Keywords酵素 / 抗酸化 / キャリア / ミトコンドリア
Research Abstract

In this research, we have prepared the Mn-porphyrin-dimer-loaded liposomes for the rescue of H2O2-damaged cells. Furthermore, the antioxidative effect of the Mn-porphyrin dimer on the SOD-deficient cells and mice was examined. Moreover, we have synthesized a new Mn-porphyrin dimer to switch the enzyme activity by biological stimuli.

  • Research Products

    (6 results)

All 2013 2012 2011

All Journal Article (3 results) Presentation (3 results)

  • [Journal Article] Pharmaceutical Effect of Manganese Porphyrins on Manganese Superoxide Dismutase Deficient Mice2012

    • Author(s)
      N. Hayakawa, S. Asayama, Y. Noda, ShimizuT. ShimizuT., H. Kawakami
    • Journal Title

      Mol. Pharmaceutics

      Volume: 9 Pages: 2956-2959

    • DOI

      DOI:10.1021/mp300147v

  • [Journal Article] Up-regulation of Gene Expression by Transfection to Hepetocyte Spheroids2012

    • Author(s)
      K. Hazama, S. Asayama, H. Kawakami
    • Journal Title

      Mol. Pharmaceutics

      Volume: 9 Pages: 3602-3605

    • DOI

      DOI:10.1021/mp300519v

  • [Journal Article] New water-soluble Mn-porphyrin with catalytic activity for superoxide dismutation and peroxynitrite decomposition2011

    • Author(s)
      S. Asayama , T. Nakajima, H. Kawakami
    • Journal Title

      Metallomics

      Volume: 3 Pages: 744-748

    • DOI

      DOI:10.1039/c1mt00005e

  • [Presentation] 人工カタラーゼとしてのイミダゾール基含有高分子/Mn-ポルフィリン複合体の分子設計2013

    • Author(s)
      窪田陸,朝山章一郎,川上浩良
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2013-03-29
  • [Presentation] Mn-SOD欠損細胞及びマウスに対するMnポルフィリンダイマー含有リポソームの抗酸化活性評価2012

    • Author(s)
      米田祥浩, 山口翔平,清水孝彦, 朝山章一郎, 川上浩良
    • Organizer
      第61回高分子学会年次大会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2012-05-31
  • [Presentation] Mnポルフィリンダイマーを用いたSOD欠損細胞に対する抗酸化評価2011

    • Author(s)
      窪田陸,田端久志, 清水孝彦(都健康長寿医療センター研),朝山章一郎,川上浩良
    • Organizer
      日本薬学会第131年会
    • Place of Presentation
      静岡県立大学・静岡県コンベンションアーツセンター・ツインメッセ静岡
    • Year and Date
      20110328-31

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Published: 2014-08-29  

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