2012 Fiscal Year Final Research Report
Creation of polymeric contrast agent systems possessing multiple imaging modalities
| Project/Area Number |
22300170
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
SHIRAISHI Kouichi 東京慈恵会医科大学, 医学部, 講師 (40426284)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 薬物送達システム / 画像診断 / 合成高分子 / 造影剤 / モダリティー |
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| Research Abstract |
In this study, we have designed polymer-based contrast agent carrier systems that can be applied in multiple imaging modalities;MRI, PET, SPECT, and ultrasound. Using a polymeric micelle MRI contrast agent, we succeeded in targeting to murine solid tumors and obtained substantial enhancementsof image contrast at the tumor sites. Additionally, this polymeric micelle contrast agent did not show any ABC phenomenon. Since the ABC phenomenon is seriously detrimental to multiple doses of contrast agents, this fact indicates a very high value of the polymeric micelle contrast agent in clinical use.
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[Journal Article] Hydrophobic Molecules Infiltrating into the PEG Domain of the Core/Shell Interface of a Polymeric Micelle: Evidence Obtained with Anomalous Small-Angle X-ray Scattering2013
Author(s)
Sanada, Y.; Akiba, I.; Sakurai, K. Shiraishi, K.; Yokoyama, M.;Mylonas, E.; Ohta, N.; Yagi, N.; Shinohara, Y.; Amemiya, Y
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Journal Title
Journal of the American Chemical Society
Volume: 135(7)
Pages: 2574-82
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[Journal Article] A facile preparation method of a PFC-containing nano-sized emulsion for theranostics of solid tumors2011
Author(s)
K. Shiraishi, R. Endoh, H. Furuhata, M. Nishihara, R. Suzuki, K. Maruyama, Y. Oda, J. Jo, Y. Tabata, J. Yamamoto, M. Yokoyama
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Journal Title
International J. of Pharmaceutics
Volume: 421
Pages: 379-87
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