2012 Fiscal Year Final Research Report
Inhalation of antitubercular agents for efficient treatment of tuberculosis
| Project/Area Number |
22300171
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Tokyo University of Science |
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Principal Investigator |
TERADA Hiroshi 東京理科大学, 総合研究機構, 教授 (00035544)
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| Co-Investigator(Kenkyū-buntansha) |
HIROTA Keiji 東京理科大学, 薬学部, 助教 (50516359)
TOMODA Keishiro 東京理科大学, 薬学部, 助教 (70516400)
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| Project Period (FY) |
2010 – 2012
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| Keywords | ドラッグデリバリー |
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| Research Abstract |
We found that intratracheal administration apparatus was beneficial to local delivery of antituberculosis agent formulated into dry powder microparticles to the lung of laboratory animals. The dry powders consisted of poly(glycolic-co-lactic) acid (PLGA) and the antitubercular agent rifampicin showed high antituberculosis activity in intracelluarly residing Mycobacterium bovisBCG by their efficient taken up by the macrophages in such a way that the powders were distributed widely in the alveoli region. We succeeded in developing the intratracheal administration apparatus based on Venturi effect and homogeneous delivery of the dry powders into the lung of rats, the volume of which was in a range of only several milliliters.
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[Journal Article] Fourie and Paolo Colombo2011
Author(s)
Amit Misra, Anthony J. Hickey, Carlo Rossi, Gerrit Borchard, Hiroshi Terada, Kimiko Makino, P. Bernard
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Journal Title
Inhaled drug therapy for treatment of tuberculosis Tuberculosis
Volume: 91巻
Pages: 71-81
Peer Reviewed
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