2012 Fiscal Year Final Research Report
Development of high stable biodegradable polyion complex-coated polymeric micelles as drug carriers
| Project/Area Number |
22300172
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Kansai University |
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Principal Investigator |
OYA Yuichi 関西大学, 化学生命工学部, 教授 (10213886)
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| Co-Investigator(Renkei-kenkyūsha) |
MARUYAMA Atsushi 九州大学, 先導物質化学研究所, 教授 (40190566)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 高分子ミセル / 生分解性高分子 / ドラッグキャリヤ / ポリ乳酸 / ポリペプチド / ポリイオンコンプレックス / ヒアルロン酸 / ターゲティング |
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| Research Abstract |
We prepared biodegradable polymeric micelles coated with polyanionic hyaluronic acid (HA) by polyion complex (PIC) formation from positively charged polymeric micelles consisting of amphiphilic biodegradable AB-type diblock copolymers of poly(L-lysine) and poly(L-lactide). The obtained HA-coated micelles showed extremely higher stability under diluted condition and in the presence of serum. Moreover, the HA-coated micelles specifically bound to liver sinusoidal endothelial cells. We also prepared biodegradable polymeric micelles coated with galactose bearing hyaluronic acid (Gal-HA) and investigated cell-specific recognition of the obtained Gal-HA-coated micelles. The obtained results suggested that the Gal-HA-coated micelles showed cell-specific uptake into hepatoma via galactose receptor mediated mechanism.
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[Presentation] Biodegradable Polymer Micelles Exhibiting High Stability for Drug Delivery System2012
Author(s)
Y. Ohya, S. Takeda, Y. Shibata, Y. Morimoto, A. Takahashi, A. Kuzuya, T. Ouchi, A. Kano, A. Maruyama
Organizer
12th Japan-Belgium Symposium on Polymer Science
Place of Presentation
Vrije Universiteit, Brussel, Belgium
Year and Date
2012-09-12
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[Presentation] Highly Stable Biodegradable Polymer Micelle Coated with Polyion Complex for Drug Delivery2012
Author(s)
Y. Ohya, S. Takeda, Y. Shibata, Y. Morimoto, A. Takahashi, A. Kuzuya, T. Ouchi, A. Kano, T. Iwata, S. Mochizuki, A. Maruyama
Organizer
The 3rd Research Symposium on Petrochemical and Materials Technology, and The 18th Petroleum, Petrochemicals, and Polymers
Place of Presentation
Queen Sirikit National Convention Center, Bangkok, Thailand
Year and Date
2012-04-24
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[Presentation] Polyion Complex-Coated Biodegradable Polymer Micelle Exhibiting High Stability as Cell Specific Drug Delivery Vehicle2011
Author(s)
Y. Ohya, S. Takeda, Y. Shibata, Y. Morimoto, T. Ouchi, A. Kano, T. Iwata, S. Mochizuki, Y. Taniwaki, A. Maruyama
Organizer
3rd Asian Biomaterials Congress
Place of Presentation
BEXCO, Busan, Korea.(招待講演)
Year and Date
2011-09-16
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