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2012 Fiscal Year Final Research Report

ACCELERATION OF FOCUSED ULTRASOUND TREATMENT BY HIGH-INTENSITY TRIGGER PULSES

Research Project

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Project/Area Number 22300176
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Medical systems
Research InstitutionTohoku University

Principal Investigator

UMEMURA Shinichiro  東北大学, 大学院・医工学研究科, 教授 (20402787)

Co-Investigator(Kenkyū-buntansha) YOSHIZAWA Shin  東北大学, 大学院・工学研究科, 准教授 (30455802)
Project Period (FY) 2010 – 2012
Keywords医用超音波システム / 集束超音波治療
Research Abstract

The generation of cavitated microbubbles which can potentially enhance ultrasonic heating of biological tissue was studied using a high-speed camera. An optically transparent gel with tissue-mimicking ultrasonic properties was developed and used. The generation was confirmed at an ultrasonic intensity more than the order of 10 kW/cm2. It was localized in the focal region at a pulse duration less than the order of 100 μs. The throughput of ultrasonic thermal coagulation of excised tissue was markedly improved by the generated microbubbles. Furthermore, it was discovered that the ultrasonic intensity needed for generating such cavitated microbubbles can be significantly reduced by superimposing the second harmonic to the fundamental.

  • Research Products

    (26 results)

All 2012 2011 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (21 results) Remarks (1 results)

  • [Journal Article] High-intensity focused ultrasound treatment for twin reversed arterial perfusion sequence2012

    • Author(s)
      K.Ichizuka, J.Hasegawa, M. Nakamura, R. Matsuoka, A. Sekizawa, T. Okai, S. Umemura
    • Journal Title

      ULTRASOUND IN OBSTETRICS & GYNECOLOGY

      Volume: vol. 40, no. 4 Pages: 476-478

    • DOI

      DOI:10.1002/uog.11114

    • Peer Reviewed
  • [Journal Article] UltrasonicCoagulation of Large Tissue Region by Generating Multiple Cavitation Clouds in Direction Perpendicular to Ultrasound Propagation2011

    • Author(s)
      Y. Inaba, T. Moriyama, S. Yoshizawa and S. Umemura
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: vol. 50, no. 7 Pages: 07HF13

    • DOI

      DOI:10.1143/JJAP.50.07HF13

    • Peer Reviewed
  • [Journal Article] Cavitation Inception by Dual-Frequency Excitation in High-Intensity Focused Ultrasound Treatment2011

    • Author(s)
      R. Takagi, S. Yoshizawa and S.Umemura
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: vol. 50, no. 7 Pages: 07HF14

    • DOI

      DOI:10.1143/JJAP.50.07HF14

    • Peer Reviewed
  • [Journal Article] Phase Change Nanodroplets and Microbubbles Generated from Them as Sources of Chemically Active Cavitation2011

    • Author(s)
      K. Kawabata, T. Maruoka, R. Asami and S. Umemura
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: vol. 50, no. 7 Pages: 07HE06

    • DOI

      DOI:10.1143/JJAP.50.07HE06

    • Peer Reviewed
  • [Presentation] 高周波重畳法を用いたキャビテーション気泡の効率的な発生に関する研究2012

    • Author(s)
      安田惇,浅井歩,吉澤晋,梅村晋一郎
    • Organizer
      第16回キャビテーションに関するシンポジウム
    • Place of Presentation
      金沢
    • Year and Date
      20121123-24
  • [Presentation] ゲル中でのキャビテーション気泡に対するBSA濃度の影響2012

    • Author(s)
      浅井歩,安田惇,岡野裕樹,吉澤晋,梅村晋一郎
    • Organizer
      第33回超音波エレクトロニクスの基礎と応用に関するシンポジウム(USE2012)
    • Place of Presentation
      千葉
    • Year and Date
      20121113-15
  • [Presentation] 生体模擬ゲル中での高周波重畳法によるキャビテーションの効率的な発生に関する研究2012

    • Author(s)
      安田惇,浅井歩,吉澤晋,梅村晋一郎
    • Organizer
      第33回超音波エレクトロニクスの基礎と応用に関するシンポジウム(USE2012)
    • Place of Presentation
      千葉
    • Year and Date
      20121113-15
  • [Presentation] 32ch駆動回路を用いたマルチキャビテーションクラウドの同時生成による広範囲焼灼法2012

    • Author(s)
      中村高太郎,浅井歩,高田啓介,佐々木博史,岡野裕樹,吉澤晋,梅村晋一郎
    • Organizer
      第33回超音波エレクトロニクスの基礎と応用に関するシンポジウム(USE2012)
    • Place of Presentation
      千葉
    • Year and Date
      20121113-15
  • [Presentation] マイクロ気泡による集束超音波治療の高効率化2012

    • Author(s)
      梅村晋一郎,川畑健一,吉澤晋
    • Organizer
      第33回超音波エレクトロニクスの基礎と応用に関するシンポジウム(USE2012)
    • Place of Presentation
      千葉
    • Year and Date
      20121113-15
  • [Presentation] High-speed observation of cavitation bubbles generated at multiple focal spots for bubble-enhansed heating in a large focal region2012

    • Author(s)
      S. Yoshizawa, K. Nakamura, A. Asai, and S. Umemura
    • Organizer
      2012 IEEE International Ultrasonics Symposium (IUS2012)
    • Place of Presentation
      Dresden, Germany
    • Year and Date
      20121007-10
  • [Presentation] Simultaneous generation of multiple cavitation clouds by phased arraytransducer2012

    • Author(s)
      K. Nakamura, A. Asai1, H. Sasaki, H.Okano, S. Yoshizawa, and S. Umemura
    • Organizer
      ICHO & JCTM 2012
    • Place of Presentation
      Kyoto
    • Year and Date
      20120828-31
  • [Presentation] Simulation of temperature rise induced by HIFU in tissue mimicking gel considering cavitation bubbles2012

    • Author(s)
      A. Asai, H. Okano, S. Yoshizawa, and S.Umemura
    • Organizer
      ICHO & JCTM 2012
    • Place of Presentation
      Kyoto
    • Year and Date
      20120828-31
  • [Presentation] マルチキャビテーションクラウドの同時生成を用いた効率的焼灼法2012

    • Author(s)
      中村高太郎、浅井歩、森山達也、高田啓介、吉澤晋、梅村晋一郎
    • Organizer
      日本超音波医学会第85回学術集会
    • Place of Presentation
      東京
    • Year and Date
      20120525-27
  • [Presentation] Optically transparent gel for experimentally mimicking cavitation enhanced ultrasonic heatingof tissue2012

    • Author(s)
      A. Asai, T. Moriyama, S. Yoshizawa, and S. Umemura
    • Organizer
      THE ACOUSTICS 2012
    • Place of Presentation
      Hong Kong, China
    • Year and Date
      20120513-18
  • [Presentation] High-intensity focused ultrasound heating of large tissue region enhanced by cavitation bubbles at multiple focal spots2012

    • Author(s)
      S. Yoshizawa, K. Nakamura, A.Asai, J. Yasuda, and S. Umemura
    • Organizer
      THE ACOUSTICS 2012
    • Place of Presentation
      Hong Kong, China
    • Year and Date
      20120513-18
  • [Presentation] Efficient generation of cavitation bubbles by dual-frequency exposure2012

    • Author(s)
      J. Yasuda, R. Takagi, S. Yoshizawa, and S. Umemura
    • Organizer
      THE ACOUSTICS 2012
    • Place of Presentation
      Hong Kong, China
    • Year and Date
      20120513-18
  • [Presentation] 超音波加熱治療の高速化を目的とした多点キャビテーション生成による広範囲焼灼手法2012

    • Author(s)
      吉澤晋,中村高太郎,浅井歩,安田惇,梅村晋一郎
    • Organizer
      第11回日本超音波治療研究会
    • Place of Presentation
      宮崎
    • Year and Date
      2012-11-18
  • [Presentation] 生体模擬ゲル中でのキャビテーション気泡を考慮した熱伝導シミュレーション2011

    • Author(s)
      森山達也,浅井歩,吉澤晋,梅村晋一郎
    • Organizer
      第32回超音波エレクトロニクスの基礎と応用に関するシンポジウム(USE2011)
    • Place of Presentation
      京都
    • Year and Date
      20111108-10
  • [Presentation] 強力集束超音波照射時にキャビテーションが豚肝臓に及ぼす温度上昇の解析2011

    • Author(s)
      岩崎永子,森山達也,浅井歩,獅子谷卓,吉澤晋,梅村晋一郎
    • Organizer
      第32回超音波エレクトロニクスの基礎と応用に関するシンポジウム(USE2011)
    • Place of Presentation
      京都
    • Year and Date
      20111108-10
  • [Presentation] 高周波重畳法を用いたキャビテーション気泡の生成効率の向上に関する研究2011

    • Author(s)
      安田惇,高木亮,吉澤晋,梅村晋一郎
    • Organizer
      第32回超音波エレクトロニクスの基礎と応用に関するシンポジウム(USE2011)
    • Place of Presentation
      京都
    • Year and Date
      20111108-10
  • [Presentation] High-Throughput Coagulation by Heating with Laterally Enlarged Focus, Enhanced by Mircobubble Clouds Created by Electronically Scanned Trigger Pulses2011

    • Author(s)
      S. Umemura, J. Okada, K. Takada, T.Moriyama, E. Iwasaki, and S. Yoshizawa
    • Organizer
      2011 IEEE International UltrasonicsSymposium (IUS2011)
    • Place of Presentation
      Orlando, U.S.A
    • Year and Date
      20111018-21
  • [Presentation] Cavitation Inception and Growth by Dual-Frequency Excitation in High-Intensity Focused Ultrasound Treatment2011

    • Author(s)
      S. Yoshizawa, J. Yasuda, and S.Umemura
    • Organizer
      2011 IEEE International Ultrasonics Symposium (IUS2011)
    • Place of Presentation
      Orlando, U.S.A
    • Year and Date
      20111018-21
  • [Presentation] 強力集束超音波治療におけるキャビテーション気泡の加熱増強作用2011

    • Author(s)
      吉澤晋,稲葉脩太,岩崎永子,森山達也,梅村晋一郎
    • Organizer
      第50回日本生体医工学会大会
    • Place of Presentation
      東京
    • Year and Date
      20110429-0501
  • [Presentation] Cavitation Inception and Growth by Dual-Frequency Excitation Method2011

    • Author(s)
      S. Yoshizawa, R. Takagi, J. Yasuda, and S. Umemura
    • Organizer
      11th International Symposium on Therapeutic Ultrasound (ISTU2011)
    • Place of Presentation
      New York, U. S. A.
    • Year and Date
      20110411-13
  • [Presentation] マルチキャビテーションクラウドの同時生成を用いた効率的焼灼法2011

    • Author(s)
      中村高太郎,高田啓介,森山達也,岡田淳平,吉澤晋,梅村晋一郎
    • Organizer
      第10回日本超音波治療研究会(JSTU10)
    • Place of Presentation
      東京
    • Year and Date
      2011-11-26
  • [Remarks]

    • URL

      http://www.ecei.tohoku.ac.jp/ume/

URL: 

Published: 2014-08-29  

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